Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Leona Ling"'
5
Data from Systemic Blockade of Transforming Growth Factor-β Signaling Augments the Efficacy of Immunogene Therapy
Autor: Steven M. Albelda, Leona Ling, Larry R. Kaiser, Michael Corbley, Xiamei Zhang, Hung Kam Cheung, Andrew Haas, Guanjun Cheng, Veena Kapoor, Jing Sun, Zvi G. Fridlender, George Buchlis, Samuel Kim
Locally produced transforming growth factor-β (TGF-β) promotes tumor-induced immunosuppression and contributes to resistance to immunotherapy. This article explores the potential for increased efficacy when combining immunotherapies with TGF-β sup
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d41750078a79ff23a176960b72aced
https://doi.org/10.1158/0008-5472.c.6498182.v1
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7
Inhibition of Alpha Interferon but Not Gamma Interferon Signal Transduction by Phorbol Esters Is Mediated by a Tyrosine Phosphatase
Autor: Michael David, Andandrew C. Larner, Leona Ling, Ken-Ichi Igarashi, Emanuel F. Petricoin, Susan Goelz, David S. Finbloom, Christopher Benjamin
Publikováno v: Molecular and Cellular Biology. 16:1419-1424
Previous studies have indicated that the expression of viral oncoproteins, cell transformation, or phorbol ester treatment of cells can inhibit alpha/beta interferon (IFN-alpha/beta)-induced gene expression. The mechanisms by which these promoters of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9f6acfba907dd02e88e40a7907162d
https://doi.org/10.1128/mcb.16.4.1419
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8
Combining anti-OX40 with an inhibitor of TGF-β signaling overcomes the immunosuppressive environment in established tumors (P2026)
Autor: Christopher Tucker, Todd Triplett, Kendra Garrison, Lihong Sun, Leona Ling, Emmanuel Akporiaye, Andrew Weinberg
Publikováno v: The Journal of Immunology. 190:132.3-132.3
OX40 (CD134, TNFRSF4), a member of the tumor necrosis factor receptor (TNFR) superfamily is expressed on activated CD4+ and CD8+ T cells. Engagement of OX40 with cognate ligand or soluble agonist enhances T cell proliferation, survival and cytokine p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34793d58f2c4b1271cac1fac2ca23758
https://doi.org/10.4049/jimmunol.190.supp.132.3
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9
A small molecule TGF-b signaling inhibitor synergizes with agonistic OX40 antibody to elicit a potent anti-tumor and anti-metastatic response in a breast cancer model (66.22)
Autor: Kendra Garrison, Xiamei Zhang, Wen-Cherng Lee, Leona Ling, Emmanuel Akporiaye
Publikováno v: The Journal of Immunology. 186:66.22-66.22
SM16 is an orally available small molecule TGF-b signaling inhibitor that binds to the ATP pocket of TGF-b receptor Type 1 and prevents phosphorylation by TGF-BRII following engagement of the ligand. OX40 (CD134) is a member of the TNF-a receptor sup
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fd73f36ccd2faf4365939c245efdffc
https://doi.org/10.4049/jimmunol.186.supp.66.22
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