Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Leona H. Gagnon"'
Autor:
Jared R. Bagley, Lauren S. Bailey, Leona H. Gagnon, Hao He, Vivek M. Philip, Laura G. Reinholdt, Lisa M. Tarantino, Elissa J. Chesler, James D. Jentsch
Publikováno v:
Addiction Neuroscience, Vol 4, Iss , Pp 100045- (2022)
Impulsive behavior and impulsivity are heritable phenotypes that are strongly associated with risk for substance use disorders. Identifying the neurogenetic mechanisms that influence impulsivity may also reveal novel biological insights into addictio
Externí odkaz:
https://doaj.org/article/8d7ae0d3eb4240ea808588b686a11961
Autor:
Sam-Moon Kim, Chelsea A. Vadnie, Vivek M. Philip, Leona H. Gagnon, Kodavali V. Chowdari, Elissa J. Chesler, Colleen A. McClung, Ryan W. Logan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Circadian variability is driven by genetics and Diversity Outbred (DO) mice is a powerful tool for examining the genetics of complex traits because their high genetic and phenotypic diversity compared to conventional mouse crosses. The DO po
Externí odkaz:
https://doaj.org/article/b12b457980724ac89299756c29d2f1e8
Autor:
Jared R. Bagley, Lauren S. Bailey, Leona H. Gagnon, Hao He, Vivek M. Philip, Laura G. Reinholdt, Lisa M. Tarantino, Elissa J. Chesler, James D. Jentsch
Impulsive behavior and impulsivity are heritable phenotypes that are strongly associated with risk for substance use disorders in human subjects. Consequently, identifying the neurogenetic mechanisms that influence impulsivity may also reveal novel b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82a9a104d81b61acc54b24906b6d9d4c
https://doi.org/10.1101/2022.01.29.478259
https://doi.org/10.1101/2022.01.29.478259
Autor:
Ashley Olson, James D. Jentsch, Jared R. Bagley, Elissa J. Chesler, Laura G. Reinholdt, Rainy Dodd, Lauren S. Bailey, Lisa M. Tarantino, Stacey J. Sukoff Rizzo, Leona H. Gagnon, Vivek M. Philip, Mikayla Bolduc
Publikováno v:
Genes Brain Behav
Drugs of abuse, including alcohol and stimulants like cocaine, produce effects that are subject to individual variability, and genetic variation accounts for at least a portion of those differences. Notably, research in both animal models and human s
Autor:
Elissa J. Chesler, Rainy Dodd, Laura G. Reinholdt, J. David Jentsch, Leona H. Gagnon, Mikayla Bolduc, Stacey J. Sukoff Rizzo, Lauren S. Bailey, Jared R. Bagley, Ashley Olson, Vivek M. Philip
Drugs of abuse, including alcohol and stimulants like cocaine, produce effects that are subject to individual variability, and genetic variation accounts for at least a portion of those differences. Notably, research in both animal models and human s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f33714ed34f5843065dc71276491181e
https://doi.org/10.1101/2021.04.06.438678
https://doi.org/10.1101/2021.04.06.438678
Autor:
Vivek M. Philip, Ryan W. Logan, Kodavali V. Chowdari, Chelsea A. Vadnie, Colleen A. McClung, Sam-Moon Kim, Elissa J. Chesler, Leona H. Gagnon
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Circadian variability is driven by genetics and Diversity Outbred (DO) mice is a powerful tool for examining the genetics of complex traits because their high genetic and phenotypic diversity compared to conventional mouse crosses. The DO population
Autor:
Michael C. Saul, Jared R. Bagley, Lauren S. Bailey, Udita Datta, Price E. Dickson, Rainy Dodd, Leona H. Gagnon, Spencer B. Hugett, Violet M. Kimble, Michael Leonardo, Sam-Moon Kim, Ashley Olson, Tyler Roy, Sarah A. Schoenrock, Troy Wilcox, J. David Jentsch, Ryan W. Logan, Colleen A. McClung, Rohan H. C. Palmer, Vivek M. Philip, Laura G. Reinholdt, Stacey J. Sukoff Rizzo, Lisa M. Tarantino, Elissa J. Chesler
Concerns about external validity of rodent models and translation of findings across species are often based on narrow investigations of populations with limited diversity. Sources of individual variation – including genetics and sex – are only i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f8a40fc7aeb0a87a25e92d442eee53d
https://doi.org/10.1101/2020.02.14.949784
https://doi.org/10.1101/2020.02.14.949784
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36074 (2012)
Stereocilia, the modified microvilli projecting from the apical surfaces of the sensory hair cells of the inner ear, are essential to the mechanoelectrical transduction process underlying hearing and balance. The actin-filled stereocilia on each hair
Externí odkaz:
https://doaj.org/article/df374bfdf2d14a87a007d05ba3cf71a7
Autor:
Cong Tian, Leona H. Gagnon, Amy E. Kiernan, Benjamin E. Low, Chantal M. Longo-Guess, Michael V. Wiles, Kenneth R. Johnson
Publikováno v:
Genetics. 208:1165-1179
Distal enhancers are thought to play important roles in the spatiotemporal regulation of gene expression during embryonic development, but few predicted enhancer elements have been shown to affect transcription of their endogenous genes or to alter p
Autor:
Susan Sheehan, Jaclynn M. Lett, Kevin K. Ohlemiller, Cong Tian, Chantal M. Longo-Guess, Kenneth R. Johnson, Angela D. Schrader, Leona H. Gagnon, Ron Korstanje
Publikováno v:
Human Molecular Genetics. 26:3722-3735
Mutations of the human ATP6V1B1 gene cause distal renal tubular acidosis (dRTA; OMIM #267300) often associated with sensorineural hearing impairment; however, mice with a knockout mutation of Atp6v1b1 were reported to exhibit a compensated acidosis a