Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Autor: Akul Singhania, Christine M. Graham, Leona Gabryšová, Lúcia Moreira-Teixeira, Evangelos Stavropoulos, Jonathan M. Pitt, Probir Chakravarty, Annika Warnatsch, William J. Branchett, Laura Conejero, Jing-Wen Lin, Sophia Davidson, Mark S. Wilson, Gregory Bancroft, Jean Langhorne, Eva Frickel, Abdul K. Sesay, Simon L. Priestnall, Eleanor Herbert, Marianna Ioannou, Qian Wang, Ian R. Humphreys, Jonathan Dodd, Peter J. M. Openshaw, Katrin D. Mayer-Barber, Dragana Jankovic, Alan Sher, Clare M. Lloyd, Nicole Baldwin, Damien Chaussabel, Venizelos Papayannopoulos, Andreas Wack, Jacques F. Banchereau, Virginia M. Pascual, Anne O’Garra

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)

The authors present an extensive profile of host transcriptional respones to a diverse group of pathogens and allergens. In doing so, they identify TH1, type I IFN, TH17, and TH2 responses, that underlie each immune response in both the blood and lun

Externí odkaz: https://doaj.org/article/2de9148c41624ebdb261719be7a52d90

High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17+IL-10+ Memory CD4+ T Cell Response towards a Single IL-10–Producing Phenotype

Autor: Catherine M. Hawrylowicz, Anne O'Garra, Paul E Pfeffer, Leona Gabryšová, Elizabeth H. Mann

Publikováno v: Mann, E H, Gabryšová, L, Pfeffer, P E, O’Garra, A & Hawrylowicz, C M 2019, ' High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17 + IL-10 + Memory CD4 + T Cell Response towards a Single IL-10–Producing Phenotype ', The Journal of Immunology, vol. 202, no. 3, ji1800697, pp. 684-693 . https://doi.org/10.4049/jimmunol.1800697

Glucocorticoids are known to increase production of the anti-inflammatory cytokine IL-10, and this action is associated with their clinical efficacy in asthmatics. However, glucocorticoids also enhance the synthesis of IL-17A by PBMCs, which, in exce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304c0ae189fd87d693d31f96c1b39eae
https://doi.org/10.4049/jimmunol.1800697

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Autor: Eleanor Herbert, Damien Chaussabel, Laura Conejero, Katrin D. Mayer-Barber, Alan Sher, Jean Langhorne, Jonathan M. Pitt, Leona Gabryšová, Clare M. Lloyd, Jacques Banchereau, Simon L. Priestnall, Virginia Pascual, Qian Wang, Venizelos Papayannopoulos, Evangelos Stavropoulos, Jonathan S. Dodd, Lúcia Moreira-Teixeira, Sophia Davidson, Eva M. Frickel, Dragana Jankovic, Annika Warnatsch, Jing-wen Lin, Probir Chakravarty, Akul Singhania, William J. Branchett, Andreas Wack, Nicole Baldwin, Marianna Ioannou, Ian R. Humphreys, Christine M. Graham, Peter J. M. Openshaw, Anne O'Garra, Gregory J. Bancroft, Mark S. Wilson, Abdul Sesay

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)

Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca6933c962605b485eed723112b99d4

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells

Autor: Hagen Wende, Luke S. Cox, Caroline Hosking, Yashaswini Kannan, Anne O'Garra, Mark S. Wilson, James Briscoe, Damián Pérez-Mazliah, Xuemei Wu, Vicki Metzis, Jan Sodenkamp, Leona Gabryšová, Jean Langhorne, Michael H. Sieweke, Greg Elgar, Nicholas M. Luscombe, Raphaëlle Luisier, Marisol Alvarez-Martinez, Leena Bhaw, Krzysztof Potempa, Charlotte Whicher

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2018, 19 (5), pp.497-507
Nature Immunology, 2018, 19 (5), pp.497-507
Nature immunology

The transcription factor c-Maf induces the anti-inflammatory cytokine IL-10 in CD4+ T cells in vitro. However, the global effects of c-Maf on diverse immune responses in vivo are unknown. Here we found that c-Maf regulated IL-10 production in CD4+ T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e39f0c4d8ee5af0454f0caca88fae6b
https://hal-amu.archives-ouvertes.fr/hal-02024582

Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role

Autor: Leona Gabryšová, Anne O'Garra

Publikováno v: The Journal of Immunology. 196:4423-4425

From the 1970s to the early 1980s, there was increasing evidence for functional heterogeneity among CD4+ T cells from the work of numerous researchers. Mosmann and Coffman ([1][1]), working then at the DNAX Research Institute for Immunology in Califo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0055356f2925a8ee90aa9f3ad03293a3
https://doi.org/10.4049/jimmunol.1600646