RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes.

Autor: Kondegowda NG; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA.; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Filipowska J; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA.; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Do JS; Department of Immunology and Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA., Leon-Rivera N; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA., Li R; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hampton R; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ogyaadu S; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Levister C; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Penninger JM; IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna 1030, Austria.; Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, Canada., Reijonen H; Department of Immunology and Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA., Levy CJ; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Vasavada RC; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA.; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Publikováno v: Science advances [Sci Adv] 2023 Nov 03; Vol. 9 (44), pp. eadf5238. Date of Electronic Publication: 2023 Nov 01.

Structural characterization of hexameric shell proteins from two types of choline-utilization bacterial microcompartments.

Autor: Ochoa JM; UCLA Molecular Biology Institute, University of California Los Angeles, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA., Mijares O; Whittier College, 13406 East Philadelphia Street, Whittier, CA 90602, USA., Acosta AA; Whittier College, 13406 East Philadelphia Street, Whittier, CA 90602, USA., Escoto X; Department of Chemistry and Biochemistry, University of California Los Angeles, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA., Leon-Rivera N; Whittier College, 13406 East Philadelphia Street, Whittier, CA 90602, USA., Marshall JD; Department of Chemistry and Biochemistry, University of California Los Angeles, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA., Sawaya MR; UCLA-DOE Institute of Genomics and Proteomics, University of California Los Angeles, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA., Yeates TO; UCLA Molecular Biology Institute, University of California Los Angeles, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA.

Publikováno v: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2021 Sep 01; Vol. 77 (Pt 9), pp. 275-285. Date of Electronic Publication: 2021 Aug 24.

Inferring assembly-curving trends of bacterial micro-compartment shell hexamers from crystal structure arrangements.

Autor: Garcia-Alles, Luis F.¹ (AUTHOR) lgarciaa@insa-toulouse.fr, Fuentes-Cabrera, Miguel² (AUTHOR), Truan, Gilles¹ (AUTHOR), Reguera, David^3,4 (AUTHOR)

Publikováno v: PLoS Computational Biology. 4/5/2023, Vol. 19 Issue 4, p1-22. 22p. 1 Color Photograph, 3 Graphs.

The frequency of known germline LGR4 missense variant in the ethnic groups of West Siberia.

Autor: Gervas P; Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russia. gervaspa@oncology.tomsk.ru.; National Tomsk State University, Tomsk, Russia. gervaspa@oncology.tomsk.ru., Molokov A; Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russia., Babyshkina N; Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russia., Zherebnova A; National Tomsk State University, Tomsk, Russia., Choynzonov E; Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russia.; National Tomsk State University, Tomsk, Russia., Cherdyntseva N; Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russia.; National Tomsk State University, Tomsk, Russia.

Publikováno v: Molecular biology reports [Mol Biol Rep] 2024 Dec 07; Vol. 52 (1), pp. 42. Date of Electronic Publication: 2024 Dec 07.

Role of Leucine-Rich Repeat–Containing G-Protein-Coupled Receptors 4–6 (LGR4–6) in the Ovary and Other Female Reproductive Organs: A Literature Review.

Autor: Chang, Yu-Hsun, Wu, Kun-Chi, Wang, Kai-Hung, Ding, Dah-Ching

Publikováno v: Cell Transplantation; Jan-Dec2024, Vol. 33, p1-12, 12p