Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Leon Swell"'
Publikováno v:
Journal of Biological Chemistry. 255:2925-2933
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65b7bce45db72ad0966cfc053b6ac638
https://doi.org/10.1016/s0021-9258(19)85829-5
https://doi.org/10.1016/s0021-9258(19)85829-5
Publikováno v:
Gastroenterology. 68:335-341
Several recent studies have demonstrated that patients with cirrhosis frequently lack deoxycholic acid in bile and plasma. In order to explain this observation, comparative experiments on the colonic absorption of deoxycholic acid and on the colonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bacd26ed72a5c065515e452664714e18
https://doi.org/10.1016/s0016-5085(75)80016-3
https://doi.org/10.1016/s0016-5085(75)80016-3
Publikováno v:
Gastroenterology. 69:1379-1382
A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd4d7231d8e9889b1f5378de356419f7
https://doi.org/10.1016/s0016-5085(19)32342-x
https://doi.org/10.1016/s0016-5085(19)32342-x
Autor:
Daniel H. Gregory, Leon Swell, Mones Berman, Z R Vlahcevic, Charles C. Schwartz, L. Gregg Halloran
Publikováno v:
Journal of Clinical Investigation. 61:408-423
The present report has presented the first clear evidence in man for the existence of specific hepatic cholesterol precursor sites associated with the formation and secretion of bile acids and biliary cholesterol. These hepatic compartments derive vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70e4e018a9ba734950244e610e878d7b
https://doi.org/10.1172/jci108952
https://doi.org/10.1172/jci108952
Publikováno v:
Journal of Clinical Investigation. 55:105-114
The role of bile canalicular and microsomal membranes in the synthesis and transport of biliary lipids was investigated by using the isolated perfused rat liver model. Labeled lecithin precursors ((3H)-palmitic acid, (14C)linoleic acid, (3H)choline,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4b1f20a3bcba9b8e074d5ee6b7de69
https://doi.org/10.1172/jci107900
https://doi.org/10.1172/jci107900
Publikováno v:
Biochemical and Biophysical Research Communications. 64:1083-1089
Chenodeoxycholic acid (300 mg + 14 C) was administered orally to a bile fistula patient receiving a constant infusion of { 3 H}mevalonic acid. Suppression of endogenous cholic and chenodeoxycholic acid synthesis occurred within 2 to 4 hours and conti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead4570dbd5ff623b3ca0c6483327913
https://doi.org/10.1016/0006-291x(75)90158-8
https://doi.org/10.1016/0006-291x(75)90158-8
Publikováno v:
Journal of Clinical Investigation. 70:863-876
The purpose of this study is to delineate the immediate sources and fractional turnover of high density lipoprotein (HDL) esterified cholesterol in man. Various labeled preparations were administered in 11 experiments to six subjects who had either a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::989db2c02348f51ed158acea0c69cf8c
https://doi.org/10.1172/jci110683
https://doi.org/10.1172/jci110683
Publikováno v:
Gastroenterology. 79:620-628
Patients with advanced cirrhosis have been shown to have a marked reduction of cholic acid synthesis, while chenodeoxycholic acid synthesis was affected to a much lesser extent. This preferential impairment of cholic acid synthesis has been attribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b7b670bedb6ddcafccbd23a20ef54a1
https://doi.org/10.1016/0016-5085(80)90235-8
https://doi.org/10.1016/0016-5085(80)90235-8
Autor:
T Kuramoto, C C Schwartz, B I Cohen, Leon Swell, Gregory Dh, E. H. Mosbach, L G Halloran, Z R Vlahcevic
Publikováno v:
Journal of Biological Chemistry. 251:6308-6314
The in vivo conversion of several 5 beta-cholestane intermediates to primary bile acids was investigated in three patients with total biliary diversion. The following compounds were administered intravenously: 5 beta-[G-3H]-cholestane-3 alpha, 7 alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ce838a7680f4767df6959347a15887b
https://doi.org/10.1016/s0021-9258(20)81860-2
https://doi.org/10.1016/s0021-9258(20)81860-2
Publikováno v:
Hepatology. 1:146-150
The present report has been directed toward providing additional information on the major defects in the bile acid pathways present in patients with cirrhosis and its relevance to the problem of how bile acid synthesis is regulated in man. An unusual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e45d551833477d55367c98ec8ac339
https://doi.org/10.1002/hep.1840010210
https://doi.org/10.1002/hep.1840010210