Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Leon R, Douglas"'
Autor:
Denise S. M. Boulanger, Leon R. Douglas, Patrick J. Duriez, Yoyel Kang, Neil Dalchau, Edd James, Tim Elliott
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tapasin, a component of the major histocompatibility complex (MHC) I peptide loading complex, edits the repertoire of peptides that is presented at the cell surface by MHC I and thereby plays a key role in shaping the hierarchy of CD8+ T-cell respons
Externí odkaz:
https://doaj.org/article/2f1f27988b954152a0776d183a046b30
Autor:
Xiaojie Yu, Sonya James, James H. Felce, Blanka Kellermayer, David A. Johnston, H. T. Claude Chan, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Yasunori Watanabe, Max Crispin, Ruth R. French, Patrick J. Duriez, Leon R. Douglas, Martin J. Glennie, Mark S. Cragg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Yu et al examined a panel of both experimental and clinically-relevant TNF agonists in order to advance our understanding of the mechanisms underlying their varying activities and anti-tumor responses. They demonstrated that agonists with greater act
Externí odkaz:
https://doaj.org/article/497b996aa1574d6a946f5ee6787fec3f
Autor:
Sergio Regufe da Mota, Sarah Bailey, Rosemary A. Strivens, Annette L. Hayden, Leon R. Douglas, Patrick J. Duriez, M. Teresa Borrello, Hanae Benelkebir, A. Ganesan, Graham Packham, Simon J. Crabb
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Castrate resistant prostate cancer (CRPC) is often driven by constitutively active forms of the androgen receptor such as the V7 splice variant (AR-V7) and commonly becomes resistant to established hormonal therapy strategies such
Externí odkaz:
https://doaj.org/article/4ce9ec32f7714957826dd1a3a38d81ad
Autor:
Joseph R. Stephenson Clarke, Leon R. Douglas, Patrick J. Duriez, Dimitrios-Ilias Balourdas, Andreas C. Joerger, Raniya Khadiullina, Emil Bulatov, Matthias G. J. Baud
Publikováno v:
ACS pharmacologytranslational science. 5(11)
The tumor suppressor protein p53 is inactivated in the majority of human cancers and remains a prime target for developing new drugs to reactivate its tumor suppressing activity for anticancer therapies. The oncogenic p53 mutant Y220C accounts for ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4c292cd3b44b8d4084ffa7acad8b2f
https://pubmed.ncbi.nlm.nih.gov/36407959
https://pubmed.ncbi.nlm.nih.gov/36407959
Autor:
Metin Cetin, Gorkem Odabas, Leon R. Douglas, Patrick J. Duriez, Pelin Balcik-Ercin, Irem Yalim-Camci, Abdulkadir Emre Sayan, Tamer Yagci
Publikováno v:
Cells, Vol 8, Iss 3, p 210 (2019)
Background: Hepatocellular carcinoma (HCC) is a common and deadly cancer; however, very little improvement has been made towards its diagnosis and prognosis. The expression and functional contribution of the receptor tyrosine kinase ROR1 have not bee
Externí odkaz:
https://doaj.org/article/4b1bb8f973e04f86849cd96b386b7819
Autor:
Ivan Kadurin, Laurent Ferron, Simon W Rothwell, James O Meyer, Leon R Douglas, Claudia S Bauer, Beatrice Lana, Wojciech Margas, Orpheas Alexopoulos, Manuela Nieto-Rostro, Wendy S Pratt, Annette C Dolphin
Publikováno v:
eLife, Vol 5 (2016)
The auxiliary α2δ subunits of voltage-gated calcium channels are extracellular membrane-associated proteins, which are post-translationally cleaved into disulfide-linked polypeptides α2 and δ. We now show, using α2δ constructs containing artifi
Externí odkaz:
https://doaj.org/article/2f7362fdd4f14854ba592b3e5603d9c7
Autor:
Xiaojie, Yu, H T Claude, Chan, Christian M, Orr, Osman, Dadas, Steven G, Booth, Lekh N, Dahal, Christine A, Penfold, Lyn, O'Brien, C Ian, Mockridge, Ruth R, French, Patrick, Duriez, Leon R, Douglas, Arwen R, Pearson, Mark S, Cragg, Ivo, Tews, Martin J, Glennie, Ann L, White
Publikováno v:
Cancer cell. 33(4)
Anti-CD40 monoclonal antibodies (mAbs) that promote or inhibit receptor function hold promise as therapeutics for cancer and autoimmunity. Rules governing their diverse range of functions, however, are lacking. Here we determined characteristics of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32a6fca115b636323fb246c1334d2566
https://pubmed.ncbi.nlm.nih.gov/29634942
https://pubmed.ncbi.nlm.nih.gov/29634942