Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Leon PE"'
Autor:
Guilherme Pessoa-Amorim, Raphael Goldacre, Charles Crichton, Will Stevens, Michelle Nunn, Andy King, Dave Murray, Richard Welsh, Heather Pinches, Andrew Rees, Eva J. A. Morris, Martin J. Landray, Richard Haynes, Peter Horby, Karl Wallendszus, Leon Peto, Mark Campbell, Charlie Harper, Marion Mafham
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Randomised trials are essential to reliably assess medical interventions. Nevertheless, interpretation of such studies, particularly when considering absolute effects, is enhanced by understanding how the trial population may diff
Externí odkaz:
https://doaj.org/article/b91d442129204c7e8a25bf9575ef5e2f
Autor:
RECOVERY Collaborative Group, Peter W. Horby, Leon Peto, Natalie Staplin, Mark Campbell, Guilherme Pessoa-Amorim, Marion Mafham, Jonathan R. Emberson, Richard Stewart, Benjamin Prudon, Alison Uriel, Christopher A. Green, Devesh J. Dhasmana, Flora Malein, Jaydip Majumdar, Paul Collini, Jack Shurmer, Bryan Yates, J. Kenneth Baillie, Maya H. Buch, Jeremy Day, Saul N. Faust, Thomas Jaki, Katie Jeffery, Edmund Juszczak, Marian Knight, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Richard Haynes, Martin J. Landray
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Thera
Externí odkaz:
https://doaj.org/article/75a728a618c2428b8fc6edd78e334a73
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1910 (2024)
Impaired skeletal muscle glucose uptake is a key feature in the development of insulin resistance and type 2 diabetes. Skeletal muscle glucose uptake can be enhanced by a variety of different stimuli, including insulin and contraction as the most pro
Externí odkaz:
https://doaj.org/article/63a3d73016604dfe869d7310643a2cec
Autor:
María Inés Moreno Pallares, Mariela Lobo Hernández, Luis Carlos Gutiérrez-Moreno, León Pérez-Gutiérrez
Publikováno v:
Intropica, Pp 192-201 (2022)
El propósito de este estudio fue evaluar la asociación de las larvas de odonatos con las raíces de Eichhornia crassipes en la ciénaga La Larga. Para el muestreo de las larvas de odonatos se utilizaron técnicas estandarizadas para macroinvertebra
Externí odkaz:
https://doaj.org/article/68d2582bb6f2487c85cd51a92eb094df
Autor:
Maho Yokoyama, Leon Peto, Eric P Budgell, Nicola Jones, Elizabeth Sheridan, Jane Liu, A Sarah Walker, Nicole Stoesser, Hyun S Gweon, Martin J Llewelyn
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282584 (2023)
Antimicrobial resistance (AMR) is a threat to global public health. However, unsatisfactory approaches to directly measuring the AMR burden carried by individuals has hampered efforts to assess interventions aimed at reducing selection for AMR. Metag
Externí odkaz:
https://doaj.org/article/2be4dff542624adfb14e9d3374bbb44f
Autor:
Boon Lim, Jeremy Ratcliff, Dorota A. Nawrot, Yejiong Yu, Harshmeena R. Sanghani, Chia-Chen Hsu, Leon Peto, Simon Evans, Susanne H. Hodgson, Aikaterini Skeva, Maria Adam, Maria Panopoulou, Christos E. Zois, Katy Poncin, Sridhar R. Vasudevan, Siqi Dai, Shuai Ren, Hong Chang, Zhanfeng Cui, Peter Simmonds, Wei E. Huang, Monique I. Andersson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract We have optimised a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for the detection of SARS-CoV-2 from extracted RNA for clinical application. We improved the stability and reliability of the RT-LAMP assay by t
Externí odkaz:
https://doaj.org/article/3a8b6fea2a544cd0a2eafc13f941fe38
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7157 (2023)
This study aimed to investigate the specific role of nitric oxide (NO) in micro- and macrovascular response to a 7-day high-salt (HS) diet, specifically by measuring skin microvascular local thermal hyperemia and the flow-mediated dilation of the bra
Externí odkaz:
https://doaj.org/article/4ecf506ede1f4f8cb83adb065e7376ce
Autor:
Nicola Fawcett, Bernadette Young, Leon Peto, T. Phuong Quan, Richard Gillott, Jianhua Wu, Chris Middlemass, Sheila Weston, Derrick W. Crook, Tim E. A. Peto, Berit Muller-Pebody, Alan P. Johnson, A. Sarah Walker, Jonathan A. T. Sandoe
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background Diagnostic codes from electronic health records are widely used to assess patterns of disease. Infective endocarditis is an uncommon but serious infection, with objective diagnostic criteria. Electronic health records have been us
Externí odkaz:
https://doaj.org/article/f5ac5d4c80da43f0ada94eea0f8c279a
Autor:
Bruno Merk, Anna Detkina, Dzianis Litskevich, Michael Drury, Omid Noori-kalkhoran, Gregory Cartland-Glover, Leon Petit, Stefano Rolfo, Justin P. Elliott, Andrew R. Mount
Publikováno v:
Applied Sciences, Vol 12, Iss 9, p 4124 (2022)
Nuclear fission technologies have the potential to play a significant role in the energy mix of a net-zero and sustainable society. However, to achieve the sustainability goal two significant challenges remain: efficient and sustainable fuel usage an
Externí odkaz:
https://doaj.org/article/e260bfca704244efb3af7257f0f9639c
Autor:
David W Eyre, Sheila F Lumley, Denise O'Donnell, Mark Campbell, Elizabeth Sims, Elaine Lawson, Fiona Warren, Tim James, Stuart Cox, Alison Howarth, George Doherty, Stephanie B Hatch, James Kavanagh, Kevin K Chau, Philip W Fowler, Jeremy Swann, Denis Volk, Fan Yang-Turner, Nicole Stoesser, Philippa C Matthews, Maria Dudareva, Timothy Davies, Robert H Shaw, Leon Peto, Louise O Downs, Alexander Vogt, Ali Amini, Bernadette C Young, Philip George Drennan, Alexander J Mentzer, Donal T Skelly, Fredrik Karpe, Matt J Neville, Monique Andersson, Andrew J Brent, Nicola Jones, Lucas Martins Ferreira, Thomas Christott, Brian D Marsden, Sarah Hoosdally, Richard Cornall, Derrick W Crook, David I Stuart, Gavin Screaton, Oxford University Hospitals Staff Testing Group, Timothy EA Peto, Bruno Holthof, Anne-Marie O'Donnell, Daniel Ebner, Christopher P Conlon, Katie Jeffery, Timothy M Walker
Publikováno v:
eLife, Vol 9 (2020)
We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some
Externí odkaz:
https://doaj.org/article/e0a0320c53944dff884e403ea0af8988