Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease

Autor: Moustafa Algamal, Alyssa N. Russ, Morgan R. Miller, Steven S. Hou, Megi Maci, Leon P. Munting, Qiuchen Zhao, Dmitry Gerashchenko, Brian J. Bacskai, Ksenia V. Kastanenka

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)

Interneuron-specific lines reveal that somatostatin interneurons are hyperactive whereas pyramidal neurons and PV interneurons are ‘hypoactive’ in the APP/PS1 mouse model of Alzheimer’s Disease.

Externí odkaz: https://doaj.org/article/9442891c7a3244869aae495ba0e754c4

Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex

Autor: Valentina Perosa, Jan Oltmer, Leon P. Munting, Whitney M. Freeze, Corinne A. Auger, Ashley A. Scherlek, Andre J. van der Kouwe, Juan Eugenio Iglesias, Alessia Atzeni, Brian J. Bacskai, Anand Viswanathan, Matthew P. Frosch, Steven M. Greenberg, Susanne J. van Veluw

Publikováno v: Acta Neuropathologica, 143(3), 331-348. Springer, Cham
Acta Neuropathol
Acta Neuropathologica. SPRINGER
Acta Neuropathologica
Acta neuropathologica 143(3), 331-348 (2022). doi:10.1007/s00401-021-02393-1

Perivascular spaces (PVS) are compartments surrounding cerebral blood vessels that become visible on MRI when enlarged. Enlarged PVS (EPVS) are commonly seen in patients with cerebral small vessel disease (CSVD) and have been suggested to reflect dys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484ca17f7550c5706a8a6f930ad2507e
https://doi.org/10.1007/s00401-021-02393-1

Hyperactive somatostatin interneurons near amyloid plaque and cell-type-specific firing deficits in a mouse model of Alzheimer’s disease

Autor: Moustafa Algamal, Alyssa N. Russ, Morgan R. Miller, Steven S. Hou, Megi Maci, Leon P. Munting, Qiuchen Zhao, Dmitry Gerashchenko, Brian J. Bacskai, Ksenia V. Kastanenka

Alzheimer’s disease (AD) is characterized by synaptic loss and neuronal network dysfunction. These network deficits are mediated by early alterations in neuronal firing rates that coincide with amyloid plaque accumulation. Mounting evidence support

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35b681277b73f949d1adcccc58f21714
https://doi.org/10.1101/2022.04.27.489759

Abstract P342: Histopathological Correlates of MRI-Visible Perivascular Spaces in Cerebral Amyloid Angiopathy

Autor: Leon P Munting, Whitney Freeze, Steven M. Greenberg, Ashley A Scherlek, Valentina Perosa, Anand Viswanathan, Susanne J. van Veluw

Publikováno v: Stroke. 52

Perivascular spaces (PVS) are fluid-filled spaces surrounding cerebral blood vessels. MRI-visible, supposedly enlarged, PVS in the centrum semiovale (CSO) have been associated with cerebral amyloid angiopathy (CAA). PVS enlargement may be due to peri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5338d40b8df47f5cf62b290b8573753f
https://doi.org/10.1161/str.52.suppl_1.p342

TGFβ pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type

Autor: Louise van der Weerd, Leon P. Munting, Willeke M. C. van Roon-Mom, Uwe Ueberham, Remco Natté, Sjoerd G. van Duinen, Marie-José Goumans, Mark A. van Buchem, Linda M. van der Graaf, Laure Grand Moursel

Publikováno v: Brain Pathology. 28:495-506

Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) pathology, caused by the E22Q mutation in the amyloid β (Aβ) peptide. Transforming growth factor β1 (TGFβ1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::489939a28c652c3e897c087a8e4c7c5d
https://doi.org/10.1111/bpa.12533