Cerebral blood flow and cerebrovascular reactivity are preserved in a mouse model of cerebral microvascular amyloidosis

Autor: Leon P Munting, Marc Derieppe, Ernst Suidgeest, Lydiane Hirschler, Matthias JP van Osch, Baudouin Denis de Senneville, Louise van der Weerd

Publikováno v: eLife, Vol 10 (2021)

Impaired cerebrovascular function is an early biomarker for cerebral amyloid angiopathy (CAA), a neurovascular disease characterized by amyloid-β accumulation in the cerebral vasculature, leading to stroke and dementia. The transgenic Swedish Dutch

Externí odkaz: https://doaj.org/article/4bb59bd105b94d219471f6eca67f1dad

Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex

Autor: Valentina Perosa, Jan Oltmer, Leon P. Munting, Whitney M. Freeze, Corinne A. Auger, Ashley A. Scherlek, Andre J. van der Kouwe, Juan Eugenio Iglesias, Alessia Atzeni, Brian J. Bacskai, Anand Viswanathan, Matthew P. Frosch, Steven M. Greenberg, Susanne J. van Veluw

Publikováno v: Acta Neuropathologica, 143(3), 331-348. Springer, Cham
Acta Neuropathol
Acta Neuropathologica. SPRINGER
Acta Neuropathologica
Acta neuropathologica 143(3), 331-348 (2022). doi:10.1007/s00401-021-02393-1

Perivascular spaces (PVS) are compartments surrounding cerebral blood vessels that become visible on MRI when enlarged. Enlarged PVS (EPVS) are commonly seen in patients with cerebral small vessel disease (CSVD) and have been suggested to reflect dys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484ca17f7550c5706a8a6f930ad2507e
https://doi.org/10.1007/s00401-021-02393-1

Hyperactive somatostatin interneurons near amyloid plaque and cell-type-specific firing deficits in a mouse model of Alzheimer’s disease

Autor: Moustafa Algamal, Alyssa N. Russ, Morgan R. Miller, Steven S. Hou, Megi Maci, Leon P. Munting, Qiuchen Zhao, Dmitry Gerashchenko, Brian J. Bacskai, Ksenia V. Kastanenka

Alzheimer’s disease (AD) is characterized by synaptic loss and neuronal network dysfunction. These network deficits are mediated by early alterations in neuronal firing rates that coincide with amyloid plaque accumulation. Mounting evidence support

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35b681277b73f949d1adcccc58f21714
https://doi.org/10.1101/2022.04.27.489759

Abstract P342: Histopathological Correlates of MRI-Visible Perivascular Spaces in Cerebral Amyloid Angiopathy

Autor: Leon P Munting, Whitney Freeze, Steven M. Greenberg, Ashley A Scherlek, Valentina Perosa, Anand Viswanathan, Susanne J. van Veluw

Publikováno v: Stroke. 52

Perivascular spaces (PVS) are fluid-filled spaces surrounding cerebral blood vessels. MRI-visible, supposedly enlarged, PVS in the centrum semiovale (CSO) have been associated with cerebral amyloid angiopathy (CAA). PVS enlargement may be due to peri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5338d40b8df47f5cf62b290b8573753f
https://doi.org/10.1161/str.52.suppl_1.p342

TGFβ pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type

Autor: Louise van der Weerd, Leon P. Munting, Willeke M. C. van Roon-Mom, Uwe Ueberham, Remco Natté, Sjoerd G. van Duinen, Marie-José Goumans, Mark A. van Buchem, Linda M. van der Graaf, Laure Grand Moursel

Publikováno v: Brain Pathology. 28:495-506

Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) pathology, caused by the E22Q mutation in the amyloid β (Aβ) peptide. Transforming growth factor β1 (TGFβ1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::489939a28c652c3e897c087a8e4c7c5d
https://doi.org/10.1111/bpa.12533