Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Leon Murphy"'
Autor:
Sarah E. Messmer, Abigail T. Elmes, Alexander F. Infante, Anna Patterson, Mackenzie Smith, Albert Leon Murphy, Antonio D. Jimenez, Stockton Mayer, Dennis P. Watson, Kevin Whitfield, Steven J. Fisher, Jennie B. Jarrett
Publikováno v:
Addiction Science & Clinical Practice, Vol 19, Iss 1, Pp 1-9 (2024)
Abstract Background Overdose deaths continue to rise within the United States, despite effective treatments such as buprenorphine and methadone for opioid use disorder (OUD). Mobile medical units with the ability to dispense buprenorphine have been d
Externí odkaz:
https://doaj.org/article/4346a41ae20f4801911ba552b49400e3
Autor:
Carlos García-Echeverría, William Sellers, Peter Finan, Leon Murphy, Marjo Simonen, Daniela Gabriel, Doriano Fabbro, Kevin Schoemaker, Alain De Pover, Patrick Chène, Saskia Brachmann, Christine Fritsch, Christian Schnell, Pascal Furet, Josef Brueggen, Frédéric Stauffer, Sauveur-Michel Maira
Supplementary Fig from Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d79b465860b280f2050c72dc6f608a8
https://doi.org/10.1158/1535-7163.22484145
https://doi.org/10.1158/1535-7163.22484145
Autor:
Carlos García-Echeverría, William Sellers, Peter Finan, Leon Murphy, Marjo Simonen, Daniela Gabriel, Doriano Fabbro, Kevin Schoemaker, Alain De Pover, Patrick Chène, Saskia Brachmann, Christine Fritsch, Christian Schnell, Pascal Furet, Josef Brueggen, Frédéric Stauffer, Sauveur-Michel Maira
Supplementary Material from Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a8caee956d009d242321055445f7b7
https://doi.org/10.1158/1535-7163.22484142.v1
https://doi.org/10.1158/1535-7163.22484142.v1
Autor:
Carlos García-Echeverría, William Sellers, Peter Finan, Leon Murphy, Marjo Simonen, Daniela Gabriel, Doriano Fabbro, Kevin Schoemaker, Alain De Pover, Patrick Chène, Saskia Brachmann, Christine Fritsch, Christian Schnell, Pascal Furet, Josef Brueggen, Frédéric Stauffer, Sauveur-Michel Maira
The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells, providing unique opportunities for anticancer therapeutic intervention. NVP-BEZ235 is an imida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f474d7f4005db8a169f18e96094e026
https://doi.org/10.1158/1535-7163.c.6531339.v1
https://doi.org/10.1158/1535-7163.c.6531339.v1
Autor:
Sarah E. Messmer, Abigail T. Elmes, Antonio D. Jimenez, Albert Leon Murphy, Miriam Guzman, Dennis P. Watson, Elisabeth Poorman, Stockton Mayer, Alexander F. Infante, Eden G. Keller, Kevin Whitfield, Jennie B. Jarrett
Publikováno v:
Journal of Substance Use and Addiction Treatment. :209054
Autor:
Daniel Baird, John H. Brumell, Kirsty Hooper, Leon Murphy, Jonathan M. Goodwin, Jeff Saunders, Sreekanth R. Rouduri, Sravya Kommineni, Archana Jha, Aylwin Ng, Oliver Florey, Menghao Wei, Taoyingnan Li, Mark R. Chance, Ward G. Walkup, Timothy Lehmberg, Sagar R. Budhe, Qing Tang, Jorge Garcia-Fortanet, Yaya Fan, Asmita Agrawal, Katherine Fletcher, Brent A. Appleton, Andrea Ballabio, Chieko Kishi-Itakura, Janna Kiselar
Publikováno v:
Science Advances. 7
Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and TFE3 in response to increased autophagic flux and endolysosomal stress, yet the molecular details of their activation are unclear. LC3 and GABARAP members of the
Autor:
Sagar R. Budhe, Qing Tang, Timothy Lehmberg, Andrea Ballabio, Katherine Fletcher, Menghao Wei, Asmita Agrawal, Daniel Baird, Sreekanth R. Rouduri, Ward G. Walkup, Oliver Florey, Archana Jha, John H. Brumell, Jorge Garcia-Fortanet, Leon Murphy, Sravya Kommineni, Kirsty Hooper, Jonathan M. Goodwin, Chieko Kishi-Itakura, Brent A. Appleton, Yaya Fan, Aylwin Ng, Janna Kiselar, Jeffrey J. Saunders, Mark R. Chance, Taoyingnan Li
Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and TFE3 in response to increased autophagic flux and endolysosomal stress, yet the molecular details of their activation are unclear. LC3 and GABARAP members of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::539ee4ceb1fc409289003ea1203b8149
https://doi.org/10.1101/2021.02.22.432209
https://doi.org/10.1101/2021.02.22.432209
Autor:
Leon Murphy, Noboru Mizushima
Publikováno v:
Trends in biochemical sciences. 45(12)
Autophagy is a lysosome-dependent intracellular degradation system required for various physiological processes and can be dysregulated in human disease. To understand its biological significance and underlying mechanisms, measuring autophagic activi
Autor:
Noel Marie-France Thomsen, Simone Bonazzi, Stephanie M. McTighe, Guiqing Liang, Danuta Lubicka, Sarah Salas, Jill Nunez, Franco Lombardo, Rajeshri Ganesh Karki, Audrey Gray, Stefan Peukert, Doug Burdette, Jean-Cosme Dodart, Leon Murphy, Grazia Piizzi, Carleton Goold, Labbe-Giguere Nancy, Erin P. Keaney, Jonathan D. Biag, Christine D. Wilson, Aakruti Gorde, Lawrence G. Hamann, Yingchuan Sun, Lin Deng, Hasnain A. Malik, Daniel Curtis, Shanming Liu
Publikováno v:
Journal of medicinal chemistry. 63(3)
Recent clinical evaluation of everolimus for seizure reduction in patients with tuberous sclerosis complex (TSC), a disease with overactivated mechanistic target of rapamycin (mTOR) signaling, has demonstrated the therapeutic value of mTOR inhibitors
Autor:
Orianne Olivares, Arunima Mukhopadhyay, Elodie M. Kuntz, Tessa L. Holyoake, Leon Murphy, Ravi K. Amaravadi, Eyal Gottlieb, Mary T. Scott, Amy Dawson, Jeffrey D. Winkler, Erin P. Keaney, Karen Dunn, Rebecca Mitchell, G. Vignir Helgason, Pablo Baquero, Michael C. Nicastri, Kevin M. Ryan, Christina Halsey, Angela Ianniciello, Alison M. Michie
Publikováno v:
Leukemia
In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs). In clinical studies hydroxychloroquine (HCQ), the only clinically approved autopha