pySuStaIn: A Python implementation of the Subtype and Stage Inference algorithm

Autor: Leon M. Aksman, Peter A. Wijeratne, Neil P. Oxtoby, Arman Eshaghi, Cameron Shand, Andre Altmann, Daniel C. Alexander, Alexandra L. Young

Publikováno v: SoftwareX, Vol 16, Iss , Pp 100811- (2021)

Progressive disorders are highly heterogeneous. Symptom-based clinical classification of these disorders may not reflect the underlying pathobiology. Data-driven subtyping and staging of patients has the potential to disentangle the complex spatiotem

Externí odkaz: https://doaj.org/article/60d8182a3cf14e42a3e007c21dcc0379

Event‐based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross‐sectional data

Autor: Seymour M, Lopez, Leon M, Aksman, Neil P, Oxtoby, Sjoerd B, Vos, Jun, Rao, Erik, Kaestner, Saud, Alhusaini, Marina, Alvim, Benjamin, Bender, Andrea, Bernasconi, Neda, Bernasconi, Boris, Bernhardt, Leonardo, Bonilha, Lorenzo, Caciagli, Benoit, Caldairou, Maria Eugenia, Caligiuri, Angels, Calvet, Fernando, Cendes, Luis, Concha, Estefania, Conde-Blanco, Esmaeil, Davoodi-Bojd, Christophe, de Bézenac, Norman, Delanty, Patricia M, Desmond, Orrin, Devinsky, Martin, Domin, John S, Duncan, Niels K, Focke, Sonya, Foley, Francesco, Fortunato, Marian, Galovic, Antonio, Gambardella, Ezequiel, Gleichgerrcht, Renzo, Guerrini, Khalid, Hamandi, Victoria, Ives-Deliperi, Graeme D, Jackson, Neda, Jahanshad, Simon S, Keller, Peter, Kochunov, Raviteja, Kotikalapudi, Barbara A K, Kreilkamp, Angelo, Labate, Sara, Larivière, Matteo, Lenge, Elaine, Lui, Charles, Malpas, Pascal, Martin, Mario, Mascalchi, Sarah E, Medland, Stefano, Meletti, Marcia E, Morita-Sherman, Thomas W, Owen, Mark, Richardson, Antonella, Riva, Theodor, Rüber, Ben, Sinclair, Hamid, Soltanian-Zadeh, Dan J, Stein, Pasquale, Striano, Peter N, Taylor, Sophia I, Thomopoulos, Paul M, Thompson, Manuela, Tondelli, Anna Elisabetta, Vaudano, Lucy, Vivash, Yujiang, Wang, Bernd, Weber, Christopher D, Whelan, Roland, Wiest, Gavin P, Winston, Clarissa Lin, Yasuda, Carrie R, McDonald, Daniel C, Alexander, Sanjay M, Sisodiya, Andre, Altmann, Rhys H, Thomas

Publikováno v: Lopez, Seymour M; Aksman, Leon M; Oxtoby, Neil P; Vos, Sjoerd B; Rao, Jun; Kaestner, Erik; Alhusaini, Saud; Alvim, Marina; Bender, Benjamin; Bernasconi, Andrea; Bernasconi, Neda; Bernhardt, Boris; Caciagli, Lorenzo; Caldairou, Benoit; Caligiuri, Maria Eugenia; Calvet, Angels; Cendes, Fernando; Concha, Luis; Conde-Blanco, Estefania; Davoodi-Bojd, Esmaeil; ... (2022). Event-based modelling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data. Epilepsia, 63(8), pp. 2081-2095. Wiley 10.1111/epi.17316

Objective: Recent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that these changes may be progressive over time. Leveraging a large multicenter cross‐sectional cohort, we investigated wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7601217bbf4acfa694890b7c07d54bf5
https://doi.org/10.1111/epi.17316

Robust Markers and Sample Sizes for Multicenter Trials of Huntington Disease

Autor: Amrita Mohan, Jane S. Paulsen, Sarah J. Tabrizi, Nellie Georgiou-Karistianis, Rachael I. Scahill, Sarah Gregory, Track-Hd Investigators, Cristina Sampaio, Hans J. Johnson, Govinda Poudel, Arman Eshaghi, Peter A. Wijeratne, Daniel C. Alexander, Predict-Hd Image-Hd, Leon M Aksman, Eileanoir B. Johnson

Publikováno v: Annals of Neurology

OBJECTIVE The identification of sensitive biomarkers is essential to validate therapeutics for Huntington disease (HD). We directly compare structural imaging markers across the largest collective imaging HD dataset to identify a set of imaging marke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cbbdd23cc8609f5c0ed40a8154d1a1
https://doi.org/10.1002/ana.25709

Data‐driven evidence for three distinct patterns of amyloid‐β accumulation

Autor: Lyduine E. Collij, Gemma Salvadó, Viktor Wottschel, Pierre Schoenmakers, Martina Mutti, Leon M Aksman, Alle Meije Wink, Wiesje M van der Flier, Philip Scheltens, Pieter Jelle Visser, Bart N.M. Van Berckel, Frederik Barkhof, Sven Haller, Juan Domingo Gispert, Isadora Lopes Alves

Publikováno v: Alzheimer's & Dementia. 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::610fc112b78d90446d84ad8115c8ce03
https://doi.org/10.1002/alz.055417

Accounting for systematic spatiotemporal variation improves connectome‐based models of tau spreading in human Alzheimer’s disease

Autor: Michel J. Grothe, Daniel C. Alexander, Neil P. Oxtoby, Leon M Aksman, Olof Strandberg, Oskar Hansson, Ruben Smith, Gil D. Rabinovici, Alexandra L. Young, Rik Ossenkoppele, Jacob W. Vogel, Alan C. Evans, Renaud La Joie

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8df761e94c9bc48f7819a9e149bc4cd
https://doi.org/10.1002/alz.040586