Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Leon M, Tai"'
Autor:
Bani Medegan Fagla, Jason York, Amy Christensen, Cielo Dela Rosa, Deebika Balu, Christian J. Pike, Leon M. Tai, Irina A. Buhimschi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Apolipoprotein E (APOE) is a major cholesterol carrier responsible for lipid transport and injury repair in the brain. The human APOE gene (h-APOE) has 3 naturally occurring alleles: ε3, the common allele; ε4, which increases Alzheimer’s
Externí odkaz:
https://doaj.org/article/d52b5cb7d04649789fb8838ad926c11e
Autor:
Deebika Balu, Ana C. Valencia-Olvera, Ashwini Deshpande, Saharsh Narayanam, Sravya Konasani, Shreya Pattisapu, Jason M. York, Gregory R. J. Thatcher, Mary Jo LaDu, Leon M. Tai
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Increasing evidence suggests that female individuals have a higher Alzheimer’s disease (AD) risk associated with post-menopausal loss of circulating estradiol (E2). However, clinical data are conflicting on whether E2 lowers AD risk. One potential
Externí odkaz:
https://doaj.org/article/c8dfbdee1ee04ce49baa722ee97324c7
Autor:
Deebika Balu, Ana C. Valencia-Olvera, Austin Nguyen, Mehul Patnam, Jason York, Francesco Peri, Frank Neumann, Mary Jo LaDu, Leon M. Tai
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background APOE genotype is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is greater in females. Evidence suggests that one-way APOE could mo
Externí odkaz:
https://doaj.org/article/de76612f85be4698b212d45dc76b6695
Autor:
Deebika Balu, Ana C. Valencia-Olvera, Zarak Islam, Clare Mielczarek, Allison Hansen, Tamara M. Perez Ramos, Jason York, Mary Jo LaDu, Leon M. Tai
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Increasing evidence supports that age, APOE and sex interact to modulate Alzheimer’s disease (AD) risk, however the underlying pathways are unclear. One way that AD risk factors may modulate cognition is by impacting amyloid beta (Aβ) accumulation
Externí odkaz:
https://doaj.org/article/9d7b4511d36d44139417aa9b06145e9c
LPC-DHA/EPA-Enriched Diets Increase Brain DHA and Modulate Behavior in Mice That Express Human APOE4
Autor:
Sarah B. Scheinman, Dhavamani Sugasini, Monay Zayed, Poorna C. R. Yalagala, Felecia M. Marottoli, Papasani V. Subbaiah, Leon M. Tai
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Compared with APOE3, APOE4 is associated with greater age-related cognitive decline and higher risk of neurodegenerative disorders. Therefore, development of supplements that target APOE genotype-modulated processes could provide a great benefit for
Externí odkaz:
https://doaj.org/article/402e36e9757946f38507070fc6122b6f
Autor:
Felecia M. Marottoli, Troy N. Trevino, Xue Geng, Zarema Arbieva, Pinal Kanabar, Mark Maienschein-Cline, James C. Lee, Sarah E. Lutz, Leon M. Tai
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Reports of APOE4-associated neurovascular dysfunction during aging and in neurodegenerative disorders has led to ongoing research to identify underlying mechanisms. In this study, we focused on whether the APOE genotype of brain endothelial cells mod
Externí odkaz:
https://doaj.org/article/9a7e56cd472340b895a41bd1b04ee7d1
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Seizures are emerging as a common symptom in Alzheimer’s disease (AD) patients, often attributed to high levels of amyloid β (Aβ). However, the extent that AD disease risk factors modulate seizure activity in aging and AD-relevant contexts is unc
Externí odkaz:
https://doaj.org/article/0577abf57ce541ea861baf1f2ad8df39
Autor:
Sarah B. Scheinman, Steve Zaldua, Adedoyin Dada, Kateryna Krochmaliuk, Katherine Dye, Felecia M. Marottoli, Gregory R. J. Thatcher, Leon M. Tai
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Evidence suggests that angiotensin receptor blockers (ARBs) could be beneficial for Alzheimer’s disease (AD) patients independent of any effects on hypertension. However, studies in rodent models directly testing the activity of ARB treatment on be
Externí odkaz:
https://doaj.org/article/fb542f03343d4d58bac9899b5cd12600
Autor:
Steve Zaldua, Frederick C. Damen, Rohan Pisharody, Riya Thomas, Kelly D. Fan, Giri K. Ekkurthi, Sarah B. Scheinman, Sami Alahmadi, Felecia M. Marottoli, Simon Alford, Kejia Cai, Leon M. Tai
Publikováno v:
Heliyon, Vol 6, Iss 5, Pp e03919- (2020)
APOE4 is a major genetic risk factor for Alzheimer's disease and high amyloid-β (Aβ) levels in the brain are a pathological hallmark of the disease. However, the contribution of specific APOE-modulated Aβ-dependent and Aβ-independent functions to
Externí odkaz:
https://doaj.org/article/06357e93928d40f2a899d980172f381e
Autor:
Ishita J. Parikh, Janice L. Estus, Diana J. Zajac, Manasi Malik, Juan Maldonado Weng, Leon M. Tai, George E. Chlipala, Mary Jo LaDu, Stefan J. Green, Steven Estus
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: Since APOE alleles represent the most impactful genetic risk factors for Alzheimer's disease (AD), their differential mechanism(s) of action are under intense scrutiny. APOE4 is robustly associated with increased AD risk compared to the n
Externí odkaz:
https://doaj.org/article/26645987dc4d42a28f6af9e70b58d52c