Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leon L. Hsieh"'
Autor:
Leon L. Hsieh, Monika Looney, Alexis Figueroa, Guido Massaccesi, Georgia Stavrakis, Eduardo U. Anaya, Franco R. D'Alessio, Alvaro A. Ordonez, Andrew S. Pekosz, Victor R. DeFilippis, Petros C. Karakousis, Andrew H. Karaba, Andrea L. Cox
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT The pathogenesis of COVID-19 is associated with a hyperinflammatory immune response. Monocytes and macrophages play a central role in this hyperinflammatory response to SARS-CoV-2. NLRP3 inflammasome activation has been observed in monocytes
Externí odkaz:
https://doaj.org/article/aa0e19b78c824561aa71c9c28ac4ee3b
Autor:
Vincent R Graziano, Forrest C Walker, Elizabeth A Kennedy, Jin Wei, Khalil Ettayebi, Madison S Strine, Renata B Filler, Ebrahim Hassan, Leon L Hsieh, Arthur S Kim, Abimbola O Kolawole, Christiane E Wobus, Lisa C Lindesmith, Ralph S Baric, Mary K Estes, Robert C Orchard, Megan T Baldridge, Craig B Wilen
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008242 (2020)
Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and mucosal virus infection more broadly. Viral receptor utilization is a major determinant of cell tropism, host range, and pathogenesis. The bona fide receptor for HNoV is unkn
Externí odkaz:
https://doaj.org/article/c2674dd032554c20845ee5f10d202eda
Autor:
Andrea L. Cox, Alexis Figueroa, Weiqiang Zhou, Matthew L Robinson, Leon L. Hsieh, Kathryn Shaw-Saliba, Nada Alachkar, Lauren Sauer, Ramy El-Diwany, Russell Wesson, Richard E. Rothman, Paul W Blair, Katherine Z.J. Fenstermacher, Guido Massaccesi, Sherry Leung, Hongkai Ji, Andrew H. Karaba
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background Several inflammatory cytokines are upregulated in severe coronavirus disease 2019 (COVID-19). We compared cytokines in COVID-19 versus influenza to define differentiating features of the inflammatory response to these pathogens and their a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26dbf911e2e871fcd3cbab066b132b8
https://doi.org/10.1093/cid/ciab376
https://doi.org/10.1093/cid/ciab376
Autor:
Madison S. Strine, Mia Madel Alfajaro, Vincent R. Graziano, Jaewon Song, Leon L. Hsieh, Ryan Hill, Jun Guo, Kelli L. VanDussen, Robert C. Orchard, Megan T. Baldridge, Sanghyun Lee, Craig B. Wilen
Publikováno v:
Cell reports. 41(6)
Murine norovirus (MNoV) is a model for human norovirus and for interrogating mechanisms of viral tropism and persistence. We previously demonstrated that the persistent strain MNoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f01df19ed3c61df0bcbfbbd38bec595
https://pubmed.ncbi.nlm.nih.gov/36351394
https://pubmed.ncbi.nlm.nih.gov/36351394
Autor:
Leon L. Hsieh, Andrea L. Cox, Nada Alachkar, Ramy El-Diwany, Lauren Sauer, Paul W Blair, Sherry Leung, Kathryn Shaw-Saliba, Weiqiang Zhou, Hongkai Ji, Alexis Figueroa, Andrew H. Karaba, Katherine Z.J. Fenstermacher, Russell Wesson, Richard E. Rothman, Guido Massaccesi
BackgroundSeveral inflammatory cytokines are upregulated in severe COVID-19. We compared cytokines in COVID-19 versus influenza in order to define differentiating features of the inflammatory response to these pathogens and their association with sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3b3f312ea649ce23f297d0788882f03
https://doi.org/10.1101/2021.01.29.21250317
https://doi.org/10.1101/2021.01.29.21250317
Autor:
Jin Wei, Vincent R. Graziano, Renata B. Filler, Sanghyun Lee, Craig B. Wilen, Mia Madel Alfajaro, Madison S. Strine, Timothy J. Nice, Cameron O. Schmitz, Megan T. Baldridge, Robert C. Orchard, Leon L. Hsieh
Publikováno v:
J Virol
Noroviruses are a leading cause of gastrointestinal infection in humans and mice. Understanding human norovirus (HuNoV) cell tropism has important implications for our understanding of viral pathogenesis. Murine norovirus (MNoV) is extensively used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad81fc14ccbbea748b40917fa1d4dcfa
https://doi.org/10.1128/jvi.01652-20
https://doi.org/10.1128/jvi.01652-20
Autor:
Madison S. Strine, Leon L. Hsieh, Mia Madel Alfajaro, Vincent R. Graziano, Jin Wei, Robert C. Orchard, Craig B. Wilen, Megan T. Baldridge, Sanghyun Lee, Cameron O. Schmitz, Renata B. Filler, Timothy J. Nice
Noroviruses are a leading cause of gastrointestinal infection in humans and mice. Understanding human norovirus (HuNoV) cell tropism has important implications for our understanding of viral pathogenesis. Murine norovirus (MNoV) is extensively used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f9672591f3e836d8d9566ddfaade0a4
https://doi.org/10.1101/2020.08.19.258467
https://doi.org/10.1101/2020.08.19.258467
Autor:
Christiane E. Wobus, Abimbola O. Kolawole, Leon L. Hsieh, Megan T. Baldridge, Madison S. Simões, Craig B. Wilen, Elizabeth A. Kennedy, Jin Wei, Lisa C. Lindesmith, Forrest C. Walker, Khalil Ettayebi, Ebrahim Hassan, Renata B. Filler, Ralph S. Baric, Robert C. Orchard, Vincent R. Graziano, Mary K. Estes
Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and mucosal virus infection more broadly. Viral receptor utilization is a major determinant of cell tropism, host range, and pathogenesis. Thebona fidereceptor for HNoV is unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03e6df9de67178a3f1b5a6ec57d9f81
Autor:
Megan T. Baldridge, Madison S. Simões, Craig B. Wilen, Christiane E. Wobus, Leon L. Hsieh, Abimbola O. Kolawole, Jin Wei, Lisa C. Lindesmith, Elizabeth A. Kennedy, Khalil Ettayebi, Ralph S. Baric, Vincent R. Graziano, Renata B. Filler, Arthur S. Kim, Forrest C. Walker, Robert C. Orchard, Mary K. Estes, Ebrahim Hassan
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 4, p e1008242 (2020)
PLoS Pathogens, Vol 16, Iss 4, p e1008242 (2020)
Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and mucosal virus infection more broadly. Viral receptor utilization is a major determinant of cell tropism, host range, and pathogenesis. The bona fide receptor for HNoV is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d57c6122ed6249649029fc78337434
https://doi.org/10.1371/journal.ppat.1008242
https://doi.org/10.1371/journal.ppat.1008242
Autor:
Thomas J. Smith, Robert C. Orchard, Arthur S. Kim, Ya Nan Dai, Craig B. Wilen, Christopher A. Nelson, Leon L. Hsieh, Roderick A. Stegeman, Daved H. Fremont, Herbert W. Virgin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The mechanisms of norovirus capsid interactions with host receptors and the mechanisms by which soluble cofactors augment norovirus infection are not understood. We recently identified CD300lf as a cell surface receptor for murine norovi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473a762e9b7b02780d60663ce458b7b3
https://doi.org/10.1073/pnas.1805797115
https://doi.org/10.1073/pnas.1805797115