Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Leon J. DeLalio"'
Autor:
T. C. Stevenson Keller, Christophe Lechauve, Alexander S. Keller, Gilson Brás Broseghini-Filho, Joshua T. Butcher, Henry R. Askew Page, Aditi Islam, Zhe Yin Tan, Leon J. DeLalio, Steven Brooks, Poonam Sharma, Kwangseok Hong, Wenhao Xu, Alessandra Simão Padilha, Claire A. Ruddiman, Angela K. Best, Edgar Macal, Daniel B. Kim-Shapiro, George Christ, Zhen Yan, Miriam M. Cortese-Krott, Karina Ricart, Rakesh Patel, Timothy P. Bender, Swapnil K. Sonkusare, Mitchell J. Weiss, Hans Ackerman, Linda Columbus, Brant E. Isakson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
In mammals, hypoxia causes dilation of small arteries for increased metabolic demand. Keller et al used novel transgenic mice to show alpha hemoglobin in endothelium, once thought only in red blood cells, can regulate hypoxic-mediated dilation.
Externí odkaz:
https://doaj.org/article/b9f465340f0741ff838bff1e07d81c95
Autor:
Bruce A. Corliss, Leon J. Delalio, T. C. Stevenson Keller, Alexander S. Keller, Douglas A. Keller, Bruce H. Corliss, Jody M. Beers, Shayn M. Peirce, Brant E. Isakson
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Frigid temperatures of the Southern Ocean are known to be an evolutionary driver in Antarctic fish. For example, many fish have reduced red blood cell (RBC) concentration to minimize vascular resistance. Via the oxygen-carrying protein hemoglobin, RB
Externí odkaz:
https://doaj.org/article/c29f96a691244be9b8e6b1c946d50eab
Autor:
Scott A. Hahn, Pedro Lourenço Katayama, Leon J. DeLalio, Sean D. Stocker, Adam C. Straub, William B. Farquhar, Megan M. Wenner
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
Renovascular hypertension is characterized by activation of the renin-angiotensin-aldosterone system, blunted natriuretic responses, and elevated sympathetic nerve activity. Excess dietary salt intake exaggerates arterial blood pressure (ABP) in mult
Autor:
Leon J. DeLalio, Rakesh P. Patel, Nhiem Y. Nguyen, Zdravka Daneva, Mohammad Y. Kalani, Kwangseok Hong, Wolfgang Liedtke, Scott R. Johnstone, Eric L. Cope, Corina Marziano, Jennifer D. Sokolowski, Swapnil K. Sonkusare, Matteo Ottolini, Min S. Park, Joachim Altschmied, Judith Haendeler, Brant E. Isakson
Publikováno v:
Circulation. 141:1318-1333
Background: Impaired endothelium-dependent vasodilation is a hallmark of obesity-induced hypertension. The recognition that Ca 2+ signaling in endothelial cells promotes vasodilation has led to the hypothesis that endothelial Ca 2+ signaling is compr
Autor:
Lauren A Biwer, Nenja Krüger, Swapnil K. Sonkusare, Louis Ragolia, Vlad Serbulea, Brant E. Isakson, Edgar Macal, Norbert Leitinger, Angela K. Best, Claire A. Ruddiman, Miranda E. Good, Sara A. Murphy, Abigail G. Wolpe, Axel Gödecke, Thurl E. Harris, Leon J. DeLalio
Publikováno v:
Circ Res
Rationale: Increasing prevalence of obesity and its associated risk with cardiovascular diseases demands a better understanding of the contribution of different cell types within this complex disease for developing new treatment options. Previous stu
Autor:
Sean D. Stocker, Leon J. DeLalio
Publikováno v:
Hypertension. 78
Elevated renal afferent nerve activity (ARNA) or dysfunctional renal reflexes contributes to hypertension and chronic kidney disease. The transient receptor potential vanilloid type-1 (TRPV1) channel is expressed in renal sensory nerves, and intraren
Autor:
Leon J. DeLalio, Sean D. Stocker
Publikováno v:
Hypertension. 78
Renal sensory nerves contribute to hypertension and renal dysfunction in chronic kidney disease. Selective chemokines (e.g., bradykinin or capsaicin) activate renal sensory nerves and produce reflexive efferent sympathetic nerve activity (SNA) and ar
Autor:
Leon J. DeLalio, Sean D. Stocker
Publikováno v:
Hypertension. 78
Renal denervation lowers arterial blood pressure (ABP) in both clinical populations and multiple experimental models of hypertension. This therapeutic effect is partly attributed to the removal of overactive renal sensory nerves that increase sympath
Autor:
Alexander W. Lohman, Xiaobin Chen, Leon J. DeLalio, Lauren A Biwer, Samuel A. Molina, Kwangseok Hong, Yen Lin Chen, Hannah M. Bacon, Zhen Yan, Miranda E. Good, Brant E. Isakson, Michael Koval, Claire A. Ruddiman, Swapnil K. Sonkusare, Nenja Krüger, Heather Skye Comstra, Daniela Maier-Begandt, Scott R. Johnstone
Publikováno v:
Sci Signal
The endothelial cell barrier regulates the passage of fluid between the bloodstream and underlying tissues, and barrier function impairment exacerbates the severity of inflammatory insults. To understand how inflammation alters vessel permeability, w