Zobrazeno 1 - 10
of 328
pro vyhledávání: '"Leon J Schurgers"'
Autor:
Stefanos Roumeliotis, Athanasios Roumeliotis, Panagiotis I Georgianos, Elias Thodis, Leon J Schurgers, Katarzyna Maresz, Theodoros Eleftheriadis, Evangelia Dounousi, Giovanni Tripepi, Francesca Mallamaci, Vassilios Liakopoulos
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273102 (2022)
Vascular calcification (VC) is an active process, resulting from the disturbance of balance between inhibitors and promoters of calcification, in favor of the latter. Matrix Gla Protein, a powerful inhibitor of VC, needs vitamin K to become active. I
Externí odkaz:
https://doaj.org/article/6bb430a7fcd44e97b390308af55b5cc5
Autor:
Serge C Harb, Samir Kapadia, Anas Saad, Toshiaki Isogai, Agam Bansal, Essa Hariri, Nicholas Kassis, Jean-Pierre Iskandar, Leon J Schurgers, Omar Abdelfattah
Publikováno v:
Open Heart, Vol 8, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/3122bba802ac47719af9b9a9b67cd9e8
Autor:
Lu Dai, Longkai Li, Helen Erlandsson, Armand M G Jaminon, Abdul Rashid Qureshi, Jonaz Ripsweden, Torkel B Brismar, Anna Witasp, Olof Heimbürger, Hanne Skou Jørgensen, Peter Barany, Bengt Lindholm, Pieter Evenepoel, Leon J Schurgers, Peter Stenvinkel
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247623 (2021)
Patients with chronic kidney disease (CKD) suffer from vitamin K deficiency and are at high risk of vascular calcification (VC) and premature death. We investigated the association of functional vitamin K deficiency with all-cause mortality and wheth
Externí odkaz:
https://doaj.org/article/da034c28f968478bbb3e7ef53b80fcd5
Autor:
Sabine R Zwakenberg, Pim A de Jong, Eva J Hendriks, Jan Westerink, Wilko Spiering, Gert J de Borst, Maarten J Cramer, Jonas W Bartstra, Teddo Doesburg, Femke Rutters, Amber A van der Heijden, Casper Schalkwijk, Leon J Schurgers, Yvonne T van der Schouw, Joline W J Beulens, SMART Study Group
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235228 (2020)
PurposeTo assess specific risk factors and biomarkers associated with intimal arterial calcification (IAC) and medial arterial calcification (MAC).MethodsWe conducted a cross-sectional study in patients with or at risk of vascular disease from the SM
Externí odkaz:
https://doaj.org/article/96a052e8f6814d2eb1a5cd19499539b6
Autor:
Thijs T Jansz, Aegida Neradova, Adriana J van Ballegooijen, Marianne C Verhaar, Marc G Vervloet, Leon J Schurgers, Brigit C van Jaarsveld
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203157 (2018)
BACKGROUND:Cardiovascular disease is the leading cause of death in end-stage renal disease and is strongly associated with vascular calcification. Both kidney transplantation and phosphate binders may lower the risk of vascular calcification. Vascula
Externí odkaz:
https://doaj.org/article/95d157ef6b2f4d278df8cc3140795a1c
Autor:
Marjo M P C Donners, Lili Bai, Suzanne P M Lutgens, Erwin Wijnands, Jason Johnson, Leon J Schurgers, Cong-Lin Liu, Mat J A P Daemen, Kitty B J M Cleutjens, Guo-Ping Shi, Erik A L Biessen, Sylvia Heeneman
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162595 (2016)
Cathepsin K (catK) is a potent lysosomal cysteine protease involved in extracellular matrix (ECM) degradation and inflammatory remodeling responses. Here we have investigated the contribution of catK deficiency on carotid arterial remodeling in respo
Externí odkaz:
https://doaj.org/article/a5988cfc01dd4c8599b1bd09867af1c3
Autor:
Dennis H M Kusters, Martijn L Chatrou, Brecht A G Willems, Marijke De Saint-Hubert, Matthias Bauwens, Emiel van der Vorst, Stefania Bena, Erik A L Biessen, Mauro Perretti, Leon J Schurgers, Chris P M Reutelingsperger
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130484 (2015)
To investigate therapeutic effects of annexin A1 (anxA1) on atherogenesis in LDLR-/- mice.Human recombinant annexin A1 (hr-anxA1) was produced by a prokaryotic expression system, purified and analysed on phosphatidylserine (PS) binding and formyl pep
Externí odkaz:
https://doaj.org/article/5f757913e6a44b8b800fc542683635ea
Autor:
Martijn L L Chatrou, Jack P Cleutjens, Ger J van der Vusse, Ruben B Roijers, Peter H A Mutsaers, Leon J Schurgers
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142335 (2015)
Vascular calcification is associated with poor cardiovascular outcome. Histochemical analysis of calcification and the expression of proteins involved in mineralization are usually based on whole section analysis, thereby often ignoring regional diff
Externí odkaz:
https://doaj.org/article/14a208deb6984307991065de4712e2ba
Autor:
Mark M. G. Mulder, Joep Schellens, Jan-Willem E. M. Sels, Frank van Rosmalen, Anne-Marije Hulshof, Femke de Vries, Ruud Segers, Casper Mihl, Walther N. K. A. van Mook, Aalt Bast, Henri M. H. Spronk, Yvonne M. C. Henskens, Iwan C. C. van der Horst, Hugo ten Cate, Leon J. Schurgers, Marjolein Drent, Bas C. T. van Bussel
Publikováno v:
Journal of Intensive Care, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Background Extra-hepatic vitamin K-status, measured by dephosphorylated uncarboxylated matrix Gla protein (dp-ucMGP), maintains vascular health, with high levels reflecting poor vitamin K status. The occurrence of extra-hepatic vitamin K def
Externí odkaz:
https://doaj.org/article/5350234c011e4986b380f9e8c03db898
Autor:
Bernard eVan Varik, Roger eRennenberg, Chris eReutelingsperger, Abraham eKroon, Peter ede Leeuw, Leon J Schurgers
Publikováno v:
Frontiers in Genetics, Vol 3 (2012)
Vascular disease is still the leading cause of morbidity and mortality in the Western world, and the primary cause of myocardial infarction, stroke, and ischemia. The biology of vascular disease is complex and still poorly understood in terms of caus
Externí odkaz:
https://doaj.org/article/b6010392d7e640c3a597054029a1a5e8