Gene-environment interactions in male reproductive health: special reference to the aryl hydrocarbon receptor signaling pathway

Autor: Leon J S Brokken, Yvonne Lundberg Giwercman

Publikováno v: Asian Journal of Andrology, Vol 16, Iss 1, Pp 89-96 (2014)

Over the last few decades, there have been numerous reports of adverse effects on the reproductive health of wildlife and laboratory animals caused by exposure to endocrine disrupting chemicals (EDCs). The increasing trends in human male reproductive

Externí odkaz: https://doaj.org/article/d849b90bee5240279307bc99da36e45a

Antiandrogen Exposure in Utero Disrupts Expression of Desert Hedgehog and Insulin-Like Factor 3 in the Developing Fetal Rat Testis

Autor: Annika Adamsson, Leon J. S. Brokken, Jorma Toppari, Jorma Paranko

Publikováno v: Endocrinology. 150:445-451

Testicular development is an androgen-dependent process, and fetal exposure to antiandrogens disrupts male sexual differentiation. A variety of testicular disorders may result from impaired development of fetal Leydig and Sertoli cells. We hypothesiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fcc5c137db22423b22d958cfc3d42a
https://doi.org/10.1210/en.2008-0230

Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis

Autor: Julie Borch, Leon J. S. Brokken, Stine Broeng Metzdorff, Majken Dalgaard, Anne Marie Vinggaard

Publikováno v: Toxicology. 223:144-155

Diethylhexyl phthalate (DEHP) is widely used as a plasticizer in consumer products and is known to disturb the development of the male reproductive system in rats. The mechanisms by which DEHP exerts these effects are not yet fully elucidated, though

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a1e15024bcb716925931a354fbf9cf
https://doi.org/10.1016/j.tox.2006.03.015

Functional thyrotropin receptor expression in the pituitary folliculo-stellate cell line TtT/GF

Autor: Wilmar M. Wiersinga, Leon J. S. Brokken, O. Bakker, Mark F. Prummel

Publikováno v: Experimental and clinical endocrinology & diabetes, 113(1), 13-20. Thieme

Thyrotropin secretion from the anterior pituitary is regulated mainly through TRH and thyroid hormones. Recent findings of a TSH receptor (TSHR) on folliculo-stellate (FS) cells in the human anterior pituitary indicate that TSH secretion might, in ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0982d3e4aacb78bb5957f9a61f4303
https://doi.org/10.1055/s-2004-830516

Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality

Autor: P.J. Lundberg, Katarzyna Góralczyk, V. Zviezdai, Leon J. S. Brokken, M. Spanò, Gunnar Toft, H.S. Pedersen, Jens Peter Bonde, Bo Jönsson, Gian Carlo Manicardi, Paweł Struciński, Y. Lundberg Giwercman, Aleksander Giwercman

Publikováno v: Europe PubMed Central
Brokken, L J S, Lundberg, P J, Spanò, M, Manicardi, G C, Pedersen, H S, Struciński, P, Góralczyk, K, Zviezdai, V, Jönsson, B A G, Bonde, J P, Toft, G, Lundberg Giwercman, Y & Giwercman, A 2014, ' Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality ', Reproductive toxicology (Elmsford, N.Y.), vol. 49C, pp. 65-73 . https://doi.org/10.1016/j.reprotox.2014.07.073

Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3241e22e159e09687b87c360d9845f
https://pubmed.ncbi.nlm.nih.gov/25084496