Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Leon Hosang"'
Autor:
Stefan A. Berghoff, Nina Gerndt, Jan Winchenbach, Sina K. Stumpf, Leon Hosang, Francesca Odoardi, Torben Ruhwedel, Carolin Böhler, Benoit Barrette, Ruth Stassart, David Liebetanz, Payam Dibaj, Wiebke Möbius, Julia M. Edgar, Gesine Saher
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Cholesterol is important for axonal myelination during development. Here the authors show that cholesterol levels are reduced in a cuprizone mouse model of multiple sclerosis and that dietary cholesterol supplementation enhances remyelination and rec
Externí odkaz:
https://doaj.org/article/3ee45ebdd5304a2ead8ae8d4b159b5bf
Autor:
Plinio D Favaro, Xiaojie Huang, Leon Hosang, Sophia Stodieck, Lei Cui, Yu-Zhang Liu, Karl-Alexander Engelhardt, Frank Schmitz, Yan Dong, Siegrid Löwel, Oliver M Schlüter
Publikováno v:
PLoS Biology, Vol 16, Iss 12, p e2006838 (2018)
The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a proc
Externí odkaz:
https://doaj.org/article/608f1cf5c5f8492c8de735c22a6fb990
Autor:
Tim Düking, Lena Spieth, Stefan A. Berghoff, Lars Piepkorn, Annika M. Schmidke, Miso Mitkovski, Nirmal Kannaiyan, Leon Hosang, Patricia Scholz, Ali H. Shaib, Lennart V. Schneider, Dörte Hesse, Torben Ruhwedel, Ting Sun, Lisa Linhoff, Andrea Trevisiol, Susanne Köhler, Adrian Marti Pastor, Thomas Misgeld, Michael Sereda, Imam Hassouna, Moritz J. Rossner, Francesca Odoardi, Till Ischebeck, Livia de Hoz, Johannes Hirrlinger, Olaf Jahn, Gesine Saher
Publikováno v:
Science Advances
Science advances 8(37), eabo7639 (2022). doi:10.1126/sciadv.abo7639
Science advances 8(37), eabo7639 (2022). doi:10.1126/sciadv.abo7639
To maintain homeostasis, the body, including the brain, reprograms its metabolism in response to altered nutrition or disease. However, the consequences of these challenges for the energy metabolism of the different brain cell types remain unknown. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429b042988b73b13bc8c23baed1b8d83
https://hdl.handle.net/21.11116/0000-000B-3BC4-621.11116/0000-000B-3BC6-4
https://hdl.handle.net/21.11116/0000-000B-3BC4-621.11116/0000-000B-3BC6-4
Autor:
Francesca Odoardi, Eva Tolosa, Anette Rosche, Wolfgang Dohle, Leon Hosang, Andreas H. Guse, Barry V. L. Potter, Sabine Windhorst, Riekje Winzer, Anke Löhndorf, Andreas Bauche, Alexander Flügel, Stephen Marry, Björn-Philipp Diercks, Sissy-Alina Waschkowski
T cell activation starts with formation of second messengers that release Ca2+ from the endoplasmic reticulum (ER) and thereby activate store-operated Ca2+ entry (SOCE), one of the essential signals for T cell activation. Recently, the steroidal 2-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb2c8fa726a5b9cc25114b1dc923648
https://ora.ox.ac.uk/objects/uuid:0625f9f7-6c8f-43ac-89bf-0f8646db7cac
https://ora.ox.ac.uk/objects/uuid:0625f9f7-6c8f-43ac-89bf-0f8646db7cac
Autor:
Lena Spieth, Roman Sankowski, David Ewers, Martin Meschkat, Stefan A. Berghoff, Mikael Simons, Jan Winchenbach, Ting Sun, Julia M. Edgar, Gesine Saher, Torben Ruhwedel, Ludovico Cantuti-Castelvetri, Christine Stadelmann-Nessler, Franziska van der Meer, Francesca Odoardi, Wiebke Möbius, Tim Düking, Klaus-Armin Nave, Michael W. Sereda, Patricia Scholz, Constanze Depp, Lennart Schlaphoff, Marco Prinz, Jonathan Neuber, Andrew Octavian Sasmita, Inge Huitinga, Till Ischebeck, Leon Hosang
Publikováno v:
Nature Neuroscience, 24, 47-60. Nature Publishing Group
Nature neuroscience.
Nature neuroscience 24(1), 47-60 (2021). doi:10.1038/s41593-020-00757-6
Nature neuroscience
Nature neuroscience.
Nature neuroscience 24(1), 47-60 (2021). doi:10.1038/s41593-020-00757-6
Nature neuroscience
The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a pro-inflammatory to an anti-inflammatory lesion environment. Subseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3611e48234b6ab2743ff34a0d63b70e8
https://pure.knaw.nl/portal/en/publications/99839925-2317-482f-84d3-35ccaca51264
https://pure.knaw.nl/portal/en/publications/99839925-2317-482f-84d3-35ccaca51264
Autor:
Leon Hosang, Roger Cugota Canals, Felicia Joy van der Flier, Jacqueline Hollensteiner, Rolf Daniel, Alexander Flügel, Francesca Odoardi
Publikováno v:
Nature. 603(7899)
Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated autoimmune disease of the central nervous system
Autor:
Anke, Löhndorf, Leon, Hosang, Wolfgang, Dohle, Francesca, Odoardi, Sissy-Alina, Waschkowski, Anette, Rosche, Andreas, Bauche, Riekje, Winzer, Eva, Tolosa, Sabine, Windhorst, Stephen, Marry, Alexander, Flügel, Barry V L, Potter, Björn-Philipp, Diercks, Andreas H, Guse
Publikováno v:
Biochimica et Biophysica Acta. Molecular Cell Research
T cell activation starts with formation of second messengers that release Ca2+ from the endoplasmic reticulum (ER) and thereby activate store-operated Ca2+ entry (SOCE), one of the essential signals for T cell activation. Recently, the steroidal 2-me
Autor:
Francesca Odoardi, Nina Gerndt, Benoit Barrette, Gesine Saher, Stefan A. Berghoff, Torben Ruhwedel, Wiebke Möbius, Sina K. Stumpf, Carolin Böhler, Leon Hosang, Julia M. Edgar, Jan Winchenbach, Ruth M. Stassart, David Liebetanz, Payam Dibaj
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Multiple Sclerosis (MS) is an inflammatory demyelinating disorder in which remyelination failure contributes to persistent disability. Cholesterol is rate-limiting for myelin biogenesis in the developing CNS; however, whether cholesterol insufficienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e11f11c3bd7749bb0eb637cdd1c394
http://resolver.sub.uni-goettingen.de/purl?gs-1/14258
http://resolver.sub.uni-goettingen.de/purl?gs-1/14258
Publikováno v:
eNeuro
For routine behavioral tasks, mice predominantly rely on olfactory cues and tactile information. In contrast, their visual capabilities appear rather restricted, raising the question whether they can improve if vision gets more behaviorally relevant.
Autor:
Leon Hosang, Xiaojie Huang, Colin Wenzel, Lei Cui, Sophia Katharina Stodieck, Yan Dong, Man Ho Wong, Siegrid Löwel, Oliver M. Schlüter, Bianka Goetze
Publikováno v:
Proceedings of the National Academy of Sciences. 112
During critical periods, all cortical neural circuits are refined to optimize their functional properties. The prevailing notion is that the balance between excitation and inhibition determines the onset and closure of critical periods. In contrast,