Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

Autor: Stefan A. Berghoff, Nina Gerndt, Jan Winchenbach, Sina K. Stumpf, Leon Hosang, Francesca Odoardi, Torben Ruhwedel, Carolin Böhler, Benoit Barrette, Ruth Stassart, David Liebetanz, Payam Dibaj, Wiebke Möbius, Julia M. Edgar, Gesine Saher

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Cholesterol is important for axonal myelination during development. Here the authors show that cholesterol levels are reduced in a cuprizone mouse model of multiple sclerosis and that dietary cholesterol supplementation enhances remyelination and rec

Externí odkaz: https://doaj.org/article/3ee45ebdd5304a2ead8ae8d4b159b5bf

Ketogenic diet uncovers differential metabolic plasticity of brain cells

Autor: Tim Düking, Lena Spieth, Stefan A. Berghoff, Lars Piepkorn, Annika M. Schmidke, Miso Mitkovski, Nirmal Kannaiyan, Leon Hosang, Patricia Scholz, Ali H. Shaib, Lennart V. Schneider, Dörte Hesse, Torben Ruhwedel, Ting Sun, Lisa Linhoff, Andrea Trevisiol, Susanne Köhler, Adrian Marti Pastor, Thomas Misgeld, Michael Sereda, Imam Hassouna, Moritz J. Rossner, Francesca Odoardi, Till Ischebeck, Livia de Hoz, Johannes Hirrlinger, Olaf Jahn, Gesine Saher

Publikováno v: Science Advances
Science advances 8(37), eabo7639 (2022). doi:10.1126/sciadv.abo7639

To maintain homeostasis, the body, including the brain, reprograms its metabolism in response to altered nutrition or disease. However, the consequences of these challenges for the energy metabolism of the different brain cell types remain unknown. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429b042988b73b13bc8c23baed1b8d83
https://hdl.handle.net/21.11116/0000-000B-3BC4-621.11116/0000-000B-3BC6-4

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Autor: Lena Spieth, Roman Sankowski, David Ewers, Martin Meschkat, Stefan A. Berghoff, Mikael Simons, Jan Winchenbach, Ting Sun, Julia M. Edgar, Gesine Saher, Torben Ruhwedel, Ludovico Cantuti-Castelvetri, Christine Stadelmann-Nessler, Franziska van der Meer, Francesca Odoardi, Wiebke Möbius, Tim Düking, Klaus-Armin Nave, Michael W. Sereda, Patricia Scholz, Constanze Depp, Lennart Schlaphoff, Marco Prinz, Jonathan Neuber, Andrew Octavian Sasmita, Inge Huitinga, Till Ischebeck, Leon Hosang

Publikováno v: Nature Neuroscience, 24, 47-60. Nature Publishing Group
Nature neuroscience.
Nature neuroscience 24(1), 47-60 (2021). doi:10.1038/s41593-020-00757-6
Nature neuroscience

The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a pro-inflammatory to an anti-inflammatory lesion environment. Subseq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3611e48234b6ab2743ff34a0d63b70e8
https://pure.knaw.nl/portal/en/publications/99839925-2317-482f-84d3-35ccaca51264

2-Methoxyestradiol and its derivatives inhibit store-operated Ca

Autor: Anke, Löhndorf, Leon, Hosang, Wolfgang, Dohle, Francesca, Odoardi, Sissy-Alina, Waschkowski, Anette, Rosche, Andreas, Bauche, Riekje, Winzer, Eva, Tolosa, Sabine, Windhorst, Stephen, Marry, Alexander, Flügel, Barry V L, Potter, Björn-Philipp, Diercks, Andreas H, Guse

Publikováno v: Biochimica et Biophysica Acta. Molecular Cell Research

T cell activation starts with formation of second messengers that release Ca2+ from the endoplasmic reticulum (ER) and thereby activate store-operated Ca2+ entry (SOCE), one of the essential signals for T cell activation. Recently, the steroidal 2-me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::650c8916b8b8725f26a562fc2fff0d16
https://pubmed.ncbi.nlm.nih.gov/33581218

Progressive maturation of silent synapses governs the duration of a critical period

Autor: Leon Hosang, Xiaojie Huang, Colin Wenzel, Lei Cui, Sophia Katharina Stodieck, Yan Dong, Man Ho Wong, Siegrid Löwel, Oliver M. Schlüter, Bianka Goetze

Publikováno v: Proceedings of the National Academy of Sciences. 112

During critical periods, all cortical neural circuits are refined to optimize their functional properties. The prevailing notion is that the balance between excitation and inhibition determines the onset and closure of critical periods. In contrast,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae702ba38388b96ead972d672f80fe4
https://doi.org/10.1073/pnas.1506488112