Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Leon H.F. Mullenders"'
Publikováno v:
DNA Repair, 113. ELSEVIER
Background: Although cancer risk is assumed to be linear with ionizing radiation (IR) dose, it is unclear to what extent low doses (LD) of IR from medical and occupational exposures pose a cancer risk for humans. Improved mechanistic understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08bae480edae0c8fcb3348e2065a56e
https://hdl.handle.net/1887/3564226
https://hdl.handle.net/1887/3564226
Publikováno v:
Molecular cell. 81(24)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9467b3e22cc2b9e60a3b56b5d84f002
https://pubmed.ncbi.nlm.nih.gov/16916636
https://pubmed.ncbi.nlm.nih.gov/16916636
Autor:
Jesper V. Olsen, Harry Vrieling, Leon H.F. Mullenders, Bharath Sampadi, Alex Pines, Branislav Misovic, Anton J.L. de Groot, Bob van de Water, Stephanie Munk
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 94(5), 1655-1671. SPRINGER HEIDELBERG
Archives of Toxicology, 94, 1655-1671
Sampadi, B, Pines, A, Munk, S, Mišovic, B, de Groot, A J, van de Water, B, Olsen, J V, Mullenders, L H F & Vrieling, H 2020, ' Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action ', Archives of Toxicology, vol. 94, pp. 1655-1671 . https://doi.org/10.1007/s00204-020-02712-7
Archives of Toxicology, 94(5), 1655-1671. SPRINGER HEIDELBERG
Archives of Toxicology, 94, 1655-1671
Sampadi, B, Pines, A, Munk, S, Mišovic, B, de Groot, A J, van de Water, B, Olsen, J V, Mullenders, L H F & Vrieling, H 2020, ' Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action ', Archives of Toxicology, vol. 94, pp. 1655-1671 . https://doi.org/10.1007/s00204-020-02712-7
Damage to cellular macromolecules and organelles by chemical exposure evokes activation of various stress response pathways. To what extent different chemical stressors activate common and stressor-specific pathways is largely unknown. Here, we used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c0066d65e3f36bdb878919dba1e9d6
https://hdl.handle.net/1887/3184412
https://hdl.handle.net/1887/3184412
Autor:
Leon H.F. Mullenders
Publikováno v:
Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences, 17(12), 1842-1852
Solar ultraviolet (UV) radiation generates bulky photodimers at di-pyrimidine sites that pose stress to cells and organisms by hindering DNA replication and transcription. In addition, solar UV also induces various types of oxidative DNA lesions and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646ca8f5278893836b4162f49ac60be2
https://doi.org/10.1039/c8pp00182k
https://doi.org/10.1039/c8pp00182k
Autor:
Martin E. van Royen, Joost Schimmel, Esra Klemann, Frauke Liebelt, Yana van der Weegen, Leon H.F. Mullenders, Matty Verlaan-de Vries, Alex Pines, Wim Vermeulen, Alfred C.O. Vertegaal, Martijn S. Luijsterburg
Publikováno v:
Nucleic Acids Research, 48(1), 231-248. OXFORD UNIV PRESS
Nucleic Acids Research
Nucleic Acids Research, 48(1), 231-248. Oxford University Press
Nucleic Acids Research
Nucleic Acids Research, 48(1), 231-248. Oxford University Press
Cockayne Syndrome (CS) is a severe neurodegenerative and premature aging autosomal-recessive disease, caused by inherited defects in the CSA and CSB genes, leading to defects in transcription-coupled nucleotide excision repair (TC-NER) and consequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ff3e5697a32c00975edfe2cfa7f1b5
https://hdl.handle.net/1887/3182621
https://hdl.handle.net/1887/3182621
Autor:
David H. Phillips, Yusaku Nakabeppu, Agnieszka Siomek-Gorecka, Jie Zuo, Teruhisa Tsuzuki, Mark D. Evans, Margherita Bignami, Rajinder Singh, Daniel Gackowski, Mutsuo Sekiguchi, Rafal Rozalski, Alex Pines, Kunihiko Sakumi, Marcus S. Cooke, Leon H.F. Mullenders, Ryszard Olinski, Vilas Mistry
Publikováno v:
Free Radical Biology and Medicine. 99:385-391
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Urinary 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo) is a widely measured biomarker of oxidative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d786cdab886e47d093cfb7ae350d13
https://doi.org/10.1016/j.freeradbiomed.2016.08.018
https://doi.org/10.1016/j.freeradbiomed.2016.08.018
Autor:
Leon H.F. Mullenders, Pim J. French, Haico van Attikum, Madelon Dijk, Martijn S. Luijsterburg, Navraj S. Pannu, Mischa G. Vrouwe, Martin E. van Royen, Wim Vermeulen, Elisabeth M. Meulenbroek, Michiel Vermeulen, Matthew M. Makowski, Alex Pines, Yana van der Weegen, Marijke P. Baltissen
Publikováno v:
Nature Communications, 9
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, 9, pp. 1-14
Nature Communications, 9:1040. Nature Publishing Group
Nature Communications, 9, 1-14
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, 9, pp. 1-14
Nature Communications, 9:1040. Nature Publishing Group
Nature Communications, 9, 1-14
Transcription-blocking DNA lesions are removed by transcription-coupled nucleotide excision repair (TC-NER) to preserve cell viability. TC-NER is triggered by the stalling of RNA polymerase II at DNA lesions, leading to the recruitment of TC-NER-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95a3006f2bd3708c2945b52996de77a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847541/pdf/41467_2018_Article_3484.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847541/pdf/41467_2018_Article_3484.pdf
Autor:
Leon H.F. Mullenders
Publikováno v:
DNA Repair. 36:28-35
The disturbance of DNA helix conformation by bulky DNA damage poses hindrance to transcription elongating due to stalling of RNA polymerase at transcription blocking lesions. Stalling of RNA polymerase provokes the formation of R-loops, i.e. the form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d358aa37c6eb6f22b60f3c8d2be4d21
https://doi.org/10.1016/j.dnarep.2015.09.005
https://doi.org/10.1016/j.dnarep.2015.09.005
Autor:
F.R. de Gruijl, Leon H.F. Mullenders
Solar UV radiation is one of the most abundant carcinogens in our natural environment. Despite its strong genotoxicity and prevalent mutations in sun-exposed adult skin, skin cancers develop mostly late in life in a minority of fair-skinned Caucasian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dce377de039b89331ebb82498effd0c3
https://doi.org/10.1016/b978-0-12-801238-3.95692-7
https://doi.org/10.1016/b978-0-12-801238-3.95692-7
Autor:
Dimitris Typas, Rick A. C. M. Boonen, Wouter W. Wiegant, Anthony M. Couturier, Marie-Christine Caron, Leon H.F. Mullenders, Diana van den Heuvel, Jean-Yves Masson, Martijn S. Luijsterburg, Haico van Attikum
Publikováno v:
eLife, Vol 6 (2017)
eLife, 6, 1-26
eLife
eLife, 6, 1-26
eLife
DNA double-strand breaks (DSB) elicit a ubiquitylation cascade that controls DNA repair pathway choice. This cascade involves the ubiquitylation of histone H2A by the RNF168 ligase and the subsequent recruitment of RIF1, which suppresses homologous r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69da09a09ebf5f725ff08c6ed07a572b
https://hdl.handle.net/1887/116008
https://hdl.handle.net/1887/116008