Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Leon H. Chew"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2024)
The choroid plexus (ChP) is a highly vascularized tissue lining the ventricular space of the brain. The ChP generates cerebrospinal fluid (CSF) and forms a protective barrier in the central nervous system (CNS). Recently, a three-dimensional human pl
Externí odkaz:
https://doaj.org/article/62c945c996584d76a05515de03a56e49
Autor:
Michael Zabolocki, Kasandra McCormack, Mark van den Hurk, Bridget Milky, Andrew P. Shoubridge, Robert Adams, Jenne Tran, Anita Mahadevan-Jansen, Philipp Reineck, Jacob Thomas, Mark R. Hutchinson, Carmen K. H. Mak, Adam Añonuevo, Leon H. Chew, Adam J. Hirst, Vivian M. Lee, Erin Knock, Cedric Bardy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Current media for neuronal cell and organoid cultures are suboptimal for functional imaging and optogenetics experiments, owing to phototoxicity and unphysiological performance. Here the authors formulate an optimised neuronal medium to support live
Externí odkaz:
https://doaj.org/article/015ec3ef1ee04a14934cb7a0fabc0fe7
Autor:
Leon H. Chew, Paul Dhillon
Publikováno v:
Journal of Military, Veteran and Family Health. 8:123-131
LAY SUMMARY Life threatening trauma and severe hemorrhage are treated using several medical principles called damage control resuscitation (DCR). Red blood cell transfusion is an essential tool in DCR and is used to address a lack of oxygen delivery
Publikováno v:
Neuromethods ISBN: 9781071628744
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53fa87a4b4ce91d7150fde989175ae48
https://doi.org/10.1007/978-1-0716-2875-1_21
https://doi.org/10.1007/978-1-0716-2875-1_21
Autor:
Andrew P. Shoubridge, Jacob Thomas, Robert J. Adams, Mark van den Hurk, Adam Añonuevo, Erin Knock, Vivian Lee, Mark R. Hutchinson, Kasandra McCormack, Leon H. Chew, Bridget Milky, Carmen K. H. Mak, Anita Mahadevan-Jansen, Michael Zabolocki, Adam J. Hirst, Jenne Tran, Cedric Bardy, Philipp Reineck
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature Communications
The capabilities of imaging technologies, fluorescent sensors, and optogenetics tools for cell biology are advancing. In parallel, cellular reprogramming and organoid engineering are expanding the use of human neuronal models in vitro. This creates a
Publikováno v:
Methods in Molecular Biology ISBN: 9781071617823
3D brain organoids derived from human pluripotent stem cells (hPSCs) possess the remarkable ability to self-organize and differentiate into tissue resembling the early human fetal brain. Brain organoids provide a powerful tool for studying human brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7ae3c6fd52a5f1c80abb37f5b6b9a9a
https://doi.org/10.1007/978-1-0716-1783-0_15
https://doi.org/10.1007/978-1-0716-1783-0_15
Autor:
Marianne Lankhorst, Adam Añonuevo, Wing Chang, Allen C. Eaves, Salvatore Simmini, Terry E. Thomas, Fisal Elstone, Leon H. Chew, Sharon A. Louis, Ryan K. Conder
Publikováno v:
Biomedical Science and Engineering. 3
Organoids are stem cell-derived structures that are generated in three-dimensional tissue culture. They are unique since they exhibit a high degree of self-organization and differentiation, and thus recapitulate many of the features of the tissues fr
Autor:
Li-Lin Du, Tamiza Nanji, Xu Liu, Franco K.K. Li, Daniel J. Klionsky, Meng-Qiu Dong, Shan Lu, Leon H. Chew, Maitree Biswas, Calvin K. Yip, Zhong Qiu Yu
Publikováno v:
Autophagy. 13:2018-2027
Although the human ULK complex mediates phagophore initiation similar to the budding yeast Saccharomyces cerevisiae Atg1 complex, this complex contains ATG101 but not Atg29 and Atg31. Here, we analyzed the fission yeast Schizosaccharomyces pombe Atg1
Autor:
Meng Qiu Dong, Daniel J. Klionsky, Calvin K. Yip, Franco K.K. Li, Xu Liu, Shan Lu, Angela Yh Yu, Leon H. Chew
Publikováno v:
Autophagy. 11:891-905
The Atg1 complex, which contains 5 major subunits: Atg1, Atg13, Atg17, Atg29, and Atg31, regulates the induction of autophagy and autophagosome formation. To gain a better understanding of the overall architecture and assembly mechanism of this essen
Publikováno v:
Autophagy. 9:1467-1474
Atg17, in complex with Atg29 and Atg31, constitutes a key module of the Atg1 kinase signaling complex and functions as an important organizer of the phagophore assembly site in the yeast Saccharomyces cerevisiae. We have determined the three-dimensio