Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes

Autor: Nurul A N Mohd Yusof, Christine L. Mummery, Leon G.J. Tertoolen, Jessica Nebel, Peter Clements, Eric I. Rossman, Umber Saleem, Ana Krotenberg Garcia, Kate Harris, Maria L. H. Vlaming, Karen McGlynn, Godfrey L. Smith, Xiaoping Xu, Puspita A Katili, Tessa de Korte, Francis L. Burton, Berend J. van Meer, Ingra Mannhardt, Arne Hansen, Chris Denning, Anthony Bahinski, Thomas Eschenhagen

Publikováno v: Toxicological Sciences
Toxicological Sciences, 176(1), 103-123. OXFORD UNIV PRESS
Toxicological Sciences, 176(1), 103-123. Oxford University Press

Animal models are 78% accurate in determining whether drugs will alter contractility of the human heart. To evaluate the suitability of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for predictive safety pharmacology, we quan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e9cc5a4d7797253c1110ea6d84aca8
http://europepmc.org/articles/PMC7357169

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin

Autor: Christine L. Mummery, Olaf van Tellingen, Hermen S. Overkleeft, Charlotte L. Zuur, Jacques Neefjes, Dennis P A Wander, Jeroen Bakker, Xiaohang Qiao, Tessa van Herwaarden, Elisa Giacomelli, Anke M. Smits, Baoxu Pang, Milena Bellin, Valeria V. Orlova, Jimmy J. Akkermans, Sophie Gerhardt, Linda Smit, J.-Y. Song, Sabina Y van der Zanden, Noortje van Gils, Ramon Arens, Junmin Li, Arjo Rutten, Daniel M. Borràs, Suzanne van Duikeren, Xiao Yang Li, Leon G.J. Tertoolen

Publikováno v: Qiao, X, van der Zanden, S Y, Wander, D P A, Borràs, D M, Song, J Y, Li, X, van Duikeren, S, van Gils, N, Rutten, A, van Herwaarden, T, van Tellingen, O, Giacomelli, E, Bellin, M, Orlova, V, Tertoolen, L G J, Gerhardt, S, Akkermans, J J, Bakker, J M, Zuur, C L, Pang, B, Smits, A M, Mummery, C L, Smit, L, Arens, R, Li, J, Overkleeft, H S & Neefjes, J 2020, ' Uncoupling DNA damage from chromatin damage to detoxify doxorubicin ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 26, pp. 15182-15192 . https://doi.org/10.1073/pnas.1922072117
Proceedings of the National Academy of Sciences, 117(26), 15182-15192. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America, 117(26), 15182-15192. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(26), 15182-15192
Proceedings of the National Academy of Sciences of the United States of America

Significance Anthracyclines like doxorubicin are anticancer drugs, used by over 1 million cancer patients annually. However, they cause severe side effects, most notably, cardiotoxicity and therapy-related malignancies. It is unclear whether these si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6082d1592787bfbc7ecf586f7775901c
https://research.vumc.nl/en/publications/6f402344-13ef-4a55-838d-a6a835f4e619

Small molecule absorption by PDMS in the context of drug response bioassays

Autor: Hermanus Bernardus Johannes Karperien, Adriaan P. IJzerman, Leon G.J. Tertoolen, B.J. van Meer, Pascal Jonkheijm, Chris Denning, H. de Vries, Christine L. Mummery, J. van Weerd, Karl S.A. Firth

Publikováno v: Biochemical and Biophysical Research Communications, 482(2), 323-328. ACADEMIC PRESS INC ELSEVIER SCIENCE
Biochemical and Biophysical Research Communications
Biochemical and biophysical research communications, 482(2), 323-328. Academic Press
Biochemical and Biophysical Research Communications, 482(2), 323-328

The polymer polydimethylsiloxane (PDMS) is widely used to build microfluidic devices compatible with cell culture. Whilst convenient in manufacture, PDMS has the disadvantage that it can absorb small molecules such as drugs. In microfluidic devices l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e760994bcd12e3221c7f0231bef984f4
https://doi.org/10.1016/j.bbrc.2016.11.062

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

Autor: Luca Sala, Christine L. Mummery, Ana Krotenberg, Leon G.J. Tertoolen, Chris Denning, Berend J. van Meer, Richard P. Davis, Thomas Eschenhagen

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature communications, 10(1):4325. Nature Publishing Group
Nature Communications, 10

Cardiomyocytes from human induced pluripotent stem cells (hiPSC-CMs) are increasingly recognized as valuable for determining the effects of drugs on ion channels but they do not always accurately predict contractile responses of the human heart. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc3691086e1053f90cfd74381baa998
https://doi.org/10.1038/s41467-019-12354-8

Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes

Autor: Leon G.J. Tertoolen, B.J. van Meer, Christine L. Mummery, Robert Passier, Stefan R. Braam

Publikováno v: Biochemical and biophysical research communications, 497(4), 1135-1141. Academic Press
Biochemical and Biophysical Research Communications

Multi electrode arrays (MEAs) are increasingly used to detect external field potentials in electrically active cells. Recently, in combination with cardiomyocytes derived from human (induced) pluripotent stem cells they have started to become a prefe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa864a0d21ca7ab825c62a2eaedc68d
https://hdl.handle.net/1887/78343