Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice

Autor: Vissarion Efthymiou, Lianggong Ding, Miroslav Balaz, Wenfei Sun, Lucia Balazova, Leon G. Straub, Hua Dong, Eric Simon, Adhideb Ghosh, Aliki Perdikari, Svenja Keller, Umesh Ghoshdastider, Carla Horvath, Caroline Moser, Bradford Hamilton, Heike Neubauer, Christian Wolfrum

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)

Abstract The current obesity epidemic and high prevalence of metabolic diseases necessitate efficacious and safe treatments. Brown adipose tissue in this context is a promising target with the potential to increase energy expenditure, however no phar

Externí odkaz: https://doaj.org/article/ef281b42140141c1891ca96fd175d996

Bmp4 Promotes a Brown to White-like Adipocyte Shift

Autor: Salvatore Modica, Leon G. Straub, Miroslav Balaz, Wenfei Sun, Lukas Varga, Patrik Stefanicka, Milan Profant, Eric Simon, Heike Neubauer, Barbara Ukropcova, Jozef Ukropec, Christian Wolfrum

Publikováno v: Cell Reports, Vol 16, Iss 8, Pp 2243-2258 (2016)

While Bmp4 has a well-established role in the commitment of mesenchymal stem cells into the adipogenic lineage, its role in brown adipocyte formation and activity is not well defined. Here, we show that Bmp4 has a dual function in adipogenesis by ind

Externí odkaz: https://doaj.org/article/c520ba9343984f0082a913c32db9852e

Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity

Autor: Philipp E. Scherer, Yu An, Ingrid Wernstedt Asterholm, Jun Yoshino, Mengle Shao, Leon G. Straub, Samuel Klein, Fang Zhang, Clair Crewe, Jan-Bernd Funcke, Shiuhwei Chen, Christine M. Kusminski, Zhuzhen Zhang, Kai Sun

Publikováno v: Nature metabolism

Mitochondrial function in white adipose tissue (WAT) is an important yet understudied aspect in adipocyte biology. Here, we report a role for amyloid precursor protein (APP) in compromising WAT mitochondrial function through a high-fat diet (HFD)-ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb746f2dcfebbc4ef72df6c1e04def5a
http://europepmc.org/articles/PMC6980705

Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis

Autor: Mengle Shao, Clair Crewe, Yi Zhu, Yongjie Yang, Xi Chen, Mason Bartels, William L. Holland, Shangang Zhao, Ruth Gordillo, Leon G. Straub, Christy M. Gliniak, Gordon I. Smith, Philipp E. Scherer, Mingyang Huang, Rana K. Gupta, Samuel Klein, Yucel Akgul, Nathalie Caron, Zhuzhen Zhang, Yong Xu, Lavanya Vishvanath, Sophie Dogné, Bingning Dong, Na Li

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Zhu, Y, Li, N, Huang, M, Bartels, M, Dogné, S, Zhao, S, Chen, X, Crewe, C, Straub, L, Vishvanath, L, Zhang, Z, Shao, M, Yang, Y, Gliniak, C M, Gordillo, R, Smith, G I, Holland, W L, Gupta, R K, Dong, B, Caron, N, Xu, Y, Akgul, Y, Klein, S & Scherer, P E 2021, ' Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis ', Nature Communications, vol. 12, no. 1, 4829 . https://doi.org/10.1038/s41467-021-25025-4

Plasma hyaluronan (HA) increases systemically in type 2 diabetes (T2D) and the HA synthesis inhibitor, 4-Methylumbelliferone, has been proposed to treat the disease. However, HA is also implicated in normal physiology. Therefore, we generated a Hyalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319833d8de3268870badd38d5d3d0dca
http://europepmc.org/articles/PMC8355239

Quantification of adipocyte numbers following adipose tissue remodeling

Autor: Christian Wolfrum, Dianne H. Dapito, Wenfei Sun, Yael Rachamin, Salvatore Modica, Caroline Moser, Elisabeth Kulenkampff, Leon G. Straub, Lianggong Ding, Miroslav Balaz

Publikováno v: Cell Reports, 35 (4)

To analyze the capacity of white and brown adipose tissue remodeling, we developed two mouse lines to label, quantitatively trace, and ablate white, brown, and brite/beige adipocytes at different ambient temperatures. We show here that the brown adip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9216cd254ce32a261fd0153ab28571
https://hdl.handle.net/20.500.11850/483990