Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Leon G. Coleman"'
Autor:
Jian Zou, Elizabeth McNair, Sagan DeCastro, Scott P. Lyons, Angie Mordant, Laura E. Herring, Ryan P. Vetreno, Leon G. Coleman Jr
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Background Alzheimer’s disease (AD) features progressive neurodegeneration and microglial activation that results in dementia and cognitive decline. The release of soluble amyloid (Aβ) oligomers into the extracellular space is an early fe
Externí odkaz:
https://doaj.org/article/b6ac96edff3a4a2cb1ff1b8d4cb09b75
Autor:
Roland F. Seim, Laura E. Herring, Angie L. Mordant, Micah L. Willis, Shannon M. Wallet, Leon G. Coleman, Robert Maile
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Acute radiation syndrome (ARS) develops after exposure to high doses of ionizing radiation and features immune suppression and organ failure. Currently, there are no diagnostics to identify the occurrence or severity of exposure and there are limited
Externí odkaz:
https://doaj.org/article/409e7dd2f55c4efa90c6c6264cde71cd
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Epidemiological studies have found that heavy alcohol use is associated with increased risk for Alzheimer’s disease (AD), with frequent drinking earlier in adulthood increasing risk. The increases in neuroinflammation featured in both heavy alcohol
Externí odkaz:
https://doaj.org/article/f426fac6a1a24f3b9dc7bd76b95c57a9
Autor:
Jian Zou, T. Jordan Walter, Alexandra Barnett, Aaron Rohlman, Fulton T. Crews, Leon G. Coleman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Adult hippocampal neurogenesis (AHN) is involved in learning and memory as well as regulation of mood. Binge ethanol reduces AHN, though the mechanism is unknown. Microglia in the neurogenic niche are important regulators of AHN, and ethanol promotes
Externí odkaz:
https://doaj.org/article/c92b23a579bd4a12912bea354faef29a
Autor:
Alexandra Barnett, Emeraghi David, Aaron Rohlman, Viktoriya D. Nikolova, Sheryl S. Moy, Ryan P. Vetreno, Leon G. Coleman
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Epidemiological studies suggest that heavy alcohol use early in life is associated with increased risk for Alzheimer’s disease (AD). However, mechanisms connecting AD with alcohol use have not been identified. Both heavy alcohol use and AD feature
Externí odkaz:
https://doaj.org/article/e5d090a48c06403ab7454b6126522146
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-20 (2020)
Abstract Background Microglia are critical mediators of neuroimmune pathology across multiple neurologic disorders. Microglia can be persistently activated or “primed” by Toll-like receptor (TLR) activation, ethanol, stress, and other insults. Th
Externí odkaz:
https://doaj.org/article/c5773e08809b470dbc38b656b57d5645
Publikováno v:
Brain Sciences, Vol 9, Iss 9, p 228 (2019)
Innate immune signaling molecules, such as Toll-like receptors (TLRs), cytokines and transcription factor NFκB, are increased in post-mortem human alcoholic brain and may play roles in alcohol dependence and neurodegeneration. Innate immune signalin
Externí odkaz:
https://doaj.org/article/1376cddf990340ebb43509bd9984f020
Autor:
Rachel H. McMahan, Paige Anton, Leon G. Coleman, Gail A.M. Cresci, Fulton T. Crews, Kathryn M. Crotty, Marisa E. Luck, Patricia E. Molina, Vidula Vachharajani, Joanne Weinberg, Samantha M. Yeligar, Mashkoor A. Choudhry, Rebecca L. McCullough, Elizabeth J. Kovacs
Publikováno v:
Alcohol. 110:57-63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::285b979eb5faf542c61fb0af19358ffd
https://doi.org/10.1016/j.alcohol.2023.04.002
https://doi.org/10.1016/j.alcohol.2023.04.002
Publikováno v:
Shock. 59:180-189
Despite advancements in critical care and resuscitation, traumatic injuries are one of the leading causes of death around the world and can bring about long-term disabilities in survivors. One of the primary causes of death for trauma patients are se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8451c8f950c643a6d9e8f0fdc6cbffc1
https://doi.org/10.1097/shk.0000000000002023
https://doi.org/10.1097/shk.0000000000002023
Publikováno v:
Pharmacological Reviews. 75:380-396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3583582ac2c8bc8b425d4481a430834
https://doi.org/10.1124/pharmrev.122.000710
https://doi.org/10.1124/pharmrev.122.000710