Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Leon G. Coleman"'
Autor:
Roland F. Seim, Laura E. Herring, Angie L. Mordant, Micah L. Willis, Shannon M. Wallet, Leon G. Coleman, Robert Maile
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Acute radiation syndrome (ARS) develops after exposure to high doses of ionizing radiation and features immune suppression and organ failure. Currently, there are no diagnostics to identify the occurrence or severity of exposure and there are limited
Externí odkaz:
https://doaj.org/article/409e7dd2f55c4efa90c6c6264cde71cd
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Epidemiological studies have found that heavy alcohol use is associated with increased risk for Alzheimer’s disease (AD), with frequent drinking earlier in adulthood increasing risk. The increases in neuroinflammation featured in both heavy alcohol
Externí odkaz:
https://doaj.org/article/f426fac6a1a24f3b9dc7bd76b95c57a9
Autor:
Jian Zou, T. Jordan Walter, Alexandra Barnett, Aaron Rohlman, Fulton T. Crews, Leon G. Coleman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Adult hippocampal neurogenesis (AHN) is involved in learning and memory as well as regulation of mood. Binge ethanol reduces AHN, though the mechanism is unknown. Microglia in the neurogenic niche are important regulators of AHN, and ethanol promotes
Externí odkaz:
https://doaj.org/article/c92b23a579bd4a12912bea354faef29a
Autor:
Alexandra Barnett, Emeraghi David, Aaron Rohlman, Viktoriya D. Nikolova, Sheryl S. Moy, Ryan P. Vetreno, Leon G. Coleman
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Epidemiological studies suggest that heavy alcohol use early in life is associated with increased risk for Alzheimer’s disease (AD). However, mechanisms connecting AD with alcohol use have not been identified. Both heavy alcohol use and AD feature
Externí odkaz:
https://doaj.org/article/e5d090a48c06403ab7454b6126522146
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-20 (2020)
Abstract Background Microglia are critical mediators of neuroimmune pathology across multiple neurologic disorders. Microglia can be persistently activated or “primed” by Toll-like receptor (TLR) activation, ethanol, stress, and other insults. Th
Externí odkaz:
https://doaj.org/article/c5773e08809b470dbc38b656b57d5645
Autor:
Robert Maile, Micah L. Willis, Laura E. Herring, Alex Prevatte, Cressida Mahung, Bruce Cairns, Shannon Wallet, Leon G. Coleman
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10083 (2021)
Severe burn injury is a devastating form of trauma that results in persistent immune dysfunction with associated morbidity and mortality. The underlying drivers of this immune dysfunction remain elusive, and there are no prognostic markers to identif
Externí odkaz:
https://doaj.org/article/c91e402fd1054e77bf2380a416031602
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2547 (2021)
Although the cause of progressive neurodegeneration is often unclear, neuronal death can occur through several mechanisms. In conditions such as Alzheimer’s or alcohol use disorder (AUD), Toll-like receptor (TLR) induction is observed with neurodeg
Externí odkaz:
https://doaj.org/article/06c8c58547fb4ee79376c7231268b4d3
Publikováno v:
Brain Sciences, Vol 9, Iss 9, p 228 (2019)
Innate immune signaling molecules, such as Toll-like receptors (TLRs), cytokines and transcription factor NFκB, are increased in post-mortem human alcoholic brain and may play roles in alcohol dependence and neurodegeneration. Innate immune signalin
Externí odkaz:
https://doaj.org/article/1376cddf990340ebb43509bd9984f020
Autor:
Rachel H. McMahan, Paige Anton, Leon G. Coleman, Gail A.M. Cresci, Fulton T. Crews, Kathryn M. Crotty, Marisa E. Luck, Patricia E. Molina, Vidula Vachharajani, Joanne Weinberg, Samantha M. Yeligar, Mashkoor A. Choudhry, Rebecca L. McCullough, Elizabeth J. Kovacs
Publikováno v:
Alcohol. 110:57-63
Publikováno v:
Shock. 59:180-189
Despite advancements in critical care and resuscitation, traumatic injuries are one of the leading causes of death around the world and can bring about long-term disabilities in survivors. One of the primary causes of death for trauma patients are se