Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Leon G, D'Cruz"'
Autor:
Andrew A. S. Soltan, Anshul Thakur, Jenny Yang, Anoop Chauhan, Leon G. D’Cruz, Phillip Dickson, Marina A. Soltan, David R. Thickett, David W. Eyre, Tingting Zhu, David A. Clifton
BackgroundTackling biases in medical artificial intelligence requires multi-centre collaboration, however, ethical, legal and entrustment considerations may restrict providers’ ability to participate. Federated learning (FL) may eliminate the need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4458402cf44e6560a2c17f8ab41c994
https://doi.org/10.1101/2023.05.05.23289554
https://doi.org/10.1101/2023.05.05.23289554
Autor:
Priyank Shukla, Preeti Pandey, Bodhayan Prasad, Tony Robinson, Rituraj Purohit, Leon G D’Cruz, Murtaza M Tambuwala, Ankur Mutreja, Jim Harkin, Taranjit Singh Rai, Elaine K Murray, David S Gibson, Anthony J Bjourson
Publikováno v:
Briefings in Bioinformatics
The current global pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has taken a substantial number of lives across the world. Although few vaccines have been rolled-out, a number of vaccine candidates are still under clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a677e1531123c267c7ce924d4f765476
https://www.repository.cam.ac.uk/handle/1810/333419
https://www.repository.cam.ac.uk/handle/1810/333419
Autor:
Leon G D'Cruz, Chris Cochrane, Dawn Small, Priyank Shukla, Kyle B.C. Tan, Philip Gardiner, Kevin G. McEleney, Shu-Dong Zhang, David Gibson
Publikováno v:
Scientific Reports
Rheumatoid arthritis (RA) is characterised by painful, stiff and swollen joints. RA features sporadic ‘flares’ or inflammatory episodes—mostly occurring outside clinics—where symptoms worsen and plasma C-reactive protein (CRP) becomes elevate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356f9d3275a56b3127c57cdfaccd8c81
https://doi.org/10.1038/s41598-020-77826-0
https://doi.org/10.1038/s41598-020-77826-0
Autor:
Priyank Shukla, Philip Gardiner, Caroline Conway, Diego Cobice, David Gibson, Leon G D'Cruz, Patricia Connolly, Kyle B.C. Tan, Kevin G. McEleney
Publikováno v:
Journal of Personalized Medicine
Volume 10
Issue 4
Journal of Personalized Medicine, Vol 10, Iss 149, p 149 (2020)
Volume 10
Issue 4
Journal of Personalized Medicine, Vol 10, Iss 149, p 149 (2020)
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that causes loss of joint function and significantly reduces quality of life. Plasma metabolite concentrations of disease-modifying anti-rheumatic drugs (DMARDs) can influence treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f19b020acd99a6b673d2cf5388199b5
https://doi.org/10.3390/jpm10040149
https://doi.org/10.3390/jpm10040149
Publikováno v:
Jacobs journal of pulmonology. 1(3)
Primary care patients with superior vena cava obstruction (SVCO) syndrome are usually referred to emergency departments for urgent medical management (high-dose corticosteroids to reduce inflammation), pre-biopsy radiotherapy and/or stent placements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d810e4acca1f89bcb04eb5c00488f2c7
https://pubmed.ncbi.nlm.nih.gov/29756081
https://pubmed.ncbi.nlm.nih.gov/29756081
Publikováno v:
Trends in Cell Biology. 18:149-156
Ryanodine receptors (RyRs) are colossal membrane protein complexes that reside in the endoplasmic reticulum of skeletal and cardiac muscle myocytes and neurons, in addition to many non-excitable cells. They comprise high-conductance ion channels that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1e11832a020a71954233b772e2091a
https://doi.org/10.1016/j.tcb.2008.02.003
https://doi.org/10.1016/j.tcb.2008.02.003
Autor:
Konrad Beck, George Nounesis, Michail Nomikos, Ewan MacDonald, Julia Griffiths, Francis Anthony Lai, Leon G D'Cruz, Lynda Blayney, Angelos Thanassoulas
Publikováno v:
Biochimica et biophysica acta. 1830(10)
BACKGROUND: This study was designed to determine whether the cardiac ryanodine receptor (RyR2) central domain, a region associated with catecholamine polymorphic ventricular tachycardia (CPVT) mutations, interacts with the RyR2 regulators, ATP and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caaab7f51739418a35bbc97eb6f52f82
https://pubmed.ncbi.nlm.nih.gov/23747301
https://pubmed.ncbi.nlm.nih.gov/23747301
Autor:
Leon G D'Cruz, G. Astrid Limb, Gavin Arno, DG Charteris, Aman Chandra, Anne H. Child, Jose Antonio Aragon-Martin
Publikováno v:
Experimental eye research. 104
The ADAMTSL4 gene (MIM:610113) is a member of the ADAMTSL (A Disintegrin AndMetalloproteinase with Thrombospondin Motifs Like) gene family. It is found on chromosome 1q21 and encodes the 1074 amino acid ADAMTS-Like 4 protein (NP_061905). ADAMTSL4 con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f27e1d2b626e709ccfcab7b964f407
https://pubmed.ncbi.nlm.nih.gov/22248912
https://pubmed.ncbi.nlm.nih.gov/22248912
Autor:
Fergus Davison, Leon G D'Cruz, C Baboonian, Hazel E Phillimore, Amanda Varnava, Rohan Taylor, Nicholas D. Carter, William J. McKenna, Perry M. Elliott
Publikováno v:
Scopus-Elsevier
Editor—Hypertrophic cardiomyopathy (HCM) is an inherited disease (MIM 192600, 115195) of the heart muscle, characterised by unexplained left ventricular hypertrophy. HCM is also one of the major causes of sudden cardiac death,1sometimes occurring i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b5a43ac3e00ed370f3c861d47f35a7
https://europepmc.org/articles/PMC1734704/
https://europepmc.org/articles/PMC1734704/
Publikováno v:
Xenotransplantation. 5(1)
Complement plays a major role in hyperacute rejection of xenografts. In order to overcome this, we are developing, by minimal mutagenesis, a modified C3 molecule that, like cobra venom factor (CVF), escapes normal complement regulatory processes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03744dcde780a757cce741831d95ebde
https://pubmed.ncbi.nlm.nih.gov/9507730
https://pubmed.ncbi.nlm.nih.gov/9507730