Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Leon Friesen"'
Autor:
Sung Rye Park, Sim Namkoong, Leon Friesen, Chun-Seok Cho, Zac Zezhi Zhang, Yu-Chih Chen, Euisik Yoon, Chang H. Kim, Hojoong Kwak, Hyun Min Kang, Jun Hee Lee
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108077- (2020)
Summary: DNA damage often induces heterogeneous cell-fate responses, such as cell-cycle arrest and apoptosis. Through single-cell RNA sequencing (scRNA-seq), we characterize the transcriptome response of cultured colon cancer cell lines to 5-fluorour
Externí odkaz:
https://doaj.org/article/facdc4df9ebe4a08abfce4382f5413e6
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin. Here the authors show that these immune cells are regulated by retinoic acid rec
Externí odkaz:
https://doaj.org/article/ee73c86e5bb4416fa97b0ac484838d96
Publikováno v:
Mucosal immunology
Summary Innate lymphoid cells (ILCs) rapidly undergo expansion in population size and functional maturation in response to cytokines that signal infection, tissue damage or changes in physiology. Optimal ILC responses are shaped, in part, by the micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f611cec532b80cb72c7d1ee9bc3fcc57
https://doi.org/10.1038/s41385-020-0312-8
https://doi.org/10.1038/s41385-020-0312-8
Publikováno v:
Mucosal immunology
Vitamin A metabolites play important roles in T cell activation and differentiation. A conventional model of RARα function relies upon retinoic acid (RA)-liganded RARα binding to specific DNA motifs to regulate gene expression in the nucleus. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a027d2abfd1d64e3612025f8a952db4e
https://doi.org/10.1038/s41385-020-0311-9
https://doi.org/10.1038/s41385-020-0311-9
Autor:
Leon Friesen, Raymond Kostlan, Qingyang Liu, Hao Yu, Jinfang Zhu, Nicholas Lukacs, Chang H. Kim
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 209(7)
IL-9, produced mainly by specialized T cells, mast cells, and group 2 innate lymphoid cells, regulates immune responses, including anti-helminth and allergic responses. Polarization of naive CD4 T cells into IL-9–producing T cells (Th9s) is induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c957929f516253f2cc375d8412905d
https://pubmed.ncbi.nlm.nih.gov/36165199
https://pubmed.ncbi.nlm.nih.gov/36165199
Publikováno v:
Sci Immunol
Early hematopoietic progenitors undergo sophisticated developmental processes to become committed progenitors for innate lymphoid cells (ILC) in hematopoietic tissues, which ultimately become mature ILC subsets in the periphery. Basic leucine zipper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac03dd94bcaff4a0443e6b1675ad6c57
https://europepmc.org/articles/PMC8375455/
https://europepmc.org/articles/PMC8375455/
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Langerhans cells (LC) are the prototype langerin-expressing dendritic cells (DC) that reside specifically in the epidermis, but langerin-expressing conventional DCs also reside in the dermis and other tissues, yet the factors that regulate their deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60dec8b02b444289f55b238cc1a70db5
http://link.springer.com/article/10.1038/s41467-018-06341-8
http://link.springer.com/article/10.1038/s41467-018-06341-8
Publikováno v:
European Journal of Immunology. 48:1235-1247
The intestinal immune system is regulated by microbes and their metabolites. The roles of gut microbial metabolites in regulating intestinal inflammation and tumorigenesis are incompletely understood. We systematically studied the roles of short-chai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d243a4f5b8ef9b3e31b1408169ef247
https://doi.org/10.1002/eji.201747122
https://doi.org/10.1002/eji.201747122
Autor:
Euisik Yoon, Chang H. Kim, Sim Namkoong, Leon Friesen, Jun Hee Lee, Hyun Min Kang, Hojoong Kwak, Sung Rye Park, Yu Chih Chen, Chun-Seok Cho, Zac Zezhi Zhang
Publikováno v:
Cell Rep
Cell Reports, Vol 32, Iss 8, Pp 108077-(2020)
Cell Reports, Vol 32, Iss 8, Pp 108077-(2020)
Summary: DNA damage often induces heterogeneous cell-fate responses, such as cell-cycle arrest and apoptosis. Through single-cell RNA sequencing (scRNA-seq), we characterize the transcriptome response of cultured colon cancer cell lines to 5-fluorour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef29bf7ebce8b9910c8294200c00bc59
https://pubmed.ncbi.nlm.nih.gov/32846134
https://pubmed.ncbi.nlm.nih.gov/32846134
Autor:
Euisik Yoon, Zac Zezhi Zhang, Hojoong Kwak, Chang H. Kim, Sung Rye Park, Jun Hee Lee, Hyun Min Kang, Leon Friesen, Yu Chih Chen, Sim Namkoong
Cancer cells often heterogeneously respond to genotoxic chemotherapy, leading to fractional killing and chemoresistance1, 2, which remain as the major obstacles in cancer treatment. It is widely believed that DNA damage induces a uniform response in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec6991d9720764cac45eb09b7e546b7
https://doi.org/10.1101/737130
https://doi.org/10.1101/737130