Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence

Autor: Ioanna A. Vamvakopoulou, Leon Fonville, Alexandra Hayes, John McGonigle, Rebecca Elliott, Karen D. Ersche, Remy Flechais, Csaba Orban, Anna Murphy, Dana G. Smith, John Suckling, Eleanor M. Taylor, Bill Deakin, Trevor W. Robbins, David J. Nutt, Anne R. Lingford-Hughes, Louise M. Paterson

Publikováno v: Frontiers in Psychiatry, Vol 13 (2022)

IntroductionNegative affective states contribute to the chronic-relapsing nature of addiction. Mesolimbic dopamine D3 receptors are well placed to modulate emotion and are dysregulated in substance dependence. Selective antagonists might restore dopa

Externí odkaz: https://doaj.org/article/4e8eb72042e4416497f16af44766cb8c

Neural Correlates of Theory of Mind Are Preserved in Young Women With Anorexia Nervosa

Autor: Monica Leslie, Daniel Halls, Jenni Leppanen, Felicity Sedgewick, Katherine Smith, Hannah Hayward, Katie Lang, Leon Fonville, Mima Simic, William Mandy, Dasha Nicholls, Declan Murphy, Steven Williams, Kate Tchanturia

Publikováno v: Frontiers in Psychology, Vol 11 (2020)

People with anorexia nervosa (AN) commonly exhibit social difficulties, which may be related to problems with understanding the perspectives of others, commonly known as Theory of Mind (ToM) processing. However, there is a dearth of literature invest

Externí odkaz: https://doaj.org/article/43def27c34ab43f8aa30450abdddc254

Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa

Autor: Leon Fonville, Vincent Giampietro, Simon Surguladze, Steven Williams, Kate Tchanturia

Publikováno v: NeuroImage: Clinical, Vol 4, Iss C, Pp 266-273 (2014)

Background: The behavioural literature in anorexia nervosa (AN) has suggested impairments in psychosocial functioning and studies using facial expression processing tasks (FEPT) have reported poorer recognition and slower identification of emotions.

Externí odkaz: https://doaj.org/article/e5416fc08e254723a3401305fef13eaf

Evaluation of enhanced attention to local detail in anorexia nervosa using the embedded figures test; an FMRI study.

Autor: Leon Fonville, Nick P Lao-Kaim, Vincent Giampietro, Frederique Van den Eynde, Helen Davies, Naima Lounes, Christopher Andrew, Jeffrey Dalton, Andrew Simmons, Steven C R Williams, Simon Baron-Cohen, Kate Tchanturia

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63964 (2013)

The behavioural literature in anorexia nervosa and autism spectrum disorders has indicated an overlap in cognitive profiles. One such domain is the enhancement of local processing over global processing. While functional imaging studies of autism spe

Externí odkaz: https://doaj.org/article/edad3a1cc61f4279abb05072cf936bef

The emotional face of anorexia nervosa: The neural correlates of emotional processing

Autor: Mima Simic, Felicity Sedgewick, Daniel Halls, Dasha Nicholls, Leon Fonville, Kate Tchanturia, Monica Leslie, Steven Williams, Katie Lang, Jenni Leppanen, Simon Surguladze

Publikováno v: Halls, D, Leslie, M, Leppanen, J, Sedgewick, F, Surguladze, S, Fonville, L, Lang, K, Simic, M, Nicholls, D, Williams, S & Tchanturia, K 2021, ' The emotional face of anorexia nervosa: The neural correlates of emotional processing ', Human Brain Mapping, vol. 42, no. 10, pp. 3077-3087 . https://doi.org/10.1002/hbm.25417
Human Brain Mapping

Social–emotional processing difficulties have been reported in Anorexia Nervosa (AN), yet the neural correlates remain unclear. Previous neuroimaging work is sparse and has not used functional connectivity paradigms to more fully explore the neural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8109f80aa172729edec6de51f6813b6d
https://hdl.handle.net/1983/32cf15f6-6a50-4723-92f7-bd49df4dc405