Zobrazeno 1 - 10
of 6 932
pro vyhledávání: '"Leon F"'
Publikováno v:
HardwareX, Vol 20, Iss , Pp e00581- (2024)
The implementation of automation has already had a considerable impact on chemical and pharmaceutical industrial laboratories. However, academic laboratories have often been more reluctant to adopt such technology due to the high cost of commercial l
Externí odkaz:
https://doaj.org/article/fa33bf41c8b144c3a28ecbcf26f5fd94
Autor:
Shubin W. Shahab, Christianna M. Roggeveen, Jiarong Sun, Haritha Kunhiraman, Leon F. McSwain, Kyle Juraschka, Sachin A. Kumar, Olivier Saulnier, Michael D. Taylor, Matthew Schniederjan, Robert W. Schnepp, Tobey J MacDonald, Anna Marie Kenney
Publikováno v:
Molecular Oncology, Vol 17, Iss 9, Pp 1784-1802 (2023)
Children with Group 3 medulloblastoma (G3 MB) have a very poor prognosis, and many do not survive beyond 5 years after diagnosis. A factor that may contribute to this is the lack of available targeted therapy. Expression of protein lin‐28 homolog B
Externí odkaz:
https://doaj.org/article/93a4f4cb469a4d629a58e2ccc4aa8c54
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101421- (2024)
Two chiral imidazolium salts and one chiral triazolium salt were synthesized containing a chiral cyclohexane bridge based on the salen ligand framework of the Jacobsen-Katsuki epoxidation catalysts. They are promising NHC and aNHC ligand precursors f
Externí odkaz:
https://doaj.org/article/5959dca796cd4fc88d81f2164d8c25a0
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2024)
Extracellular vesicles (EVs) are membrane structures enclosed by a lipid bilayer that are released into the extracellular space by all types of cells. EVs are involved in many physiological processes by transporting biologically active substances. In
Externí odkaz:
https://doaj.org/article/8ac8e52413814813b9c97e397865b7a3
Autor:
Leon F. McSwain, Claire E. Pillsbury, Ramona Haji-Seyed-Javadi, Sandip Kumar Rath, Victor Chen, Tiffany Huang, Shubin W. Shahab, Haritha Kunhiraman, James Ross, Gabrielle A. Price, Abhinav Dey, Dolores Hambardzumyan, Tobey MacDonald, David S. Yu, Christopher C. Porter, Anna M. Kenney
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Y-box binding protein 1 (YBX1 or YB1) is a therapeutically relevant oncoprotein capable of RNA and DNA binding and mediating protein–protein interactions that drive proliferation, stemness, and resistance to platinum-based therapies. Given
Externí odkaz:
https://doaj.org/article/425775788bf245a2acd870d8014152f4
Autor:
Leon F. McSwain, Claire E. Pillsbury, Ramona Haji‑Seyed‑Javadi, Sandip Kumar Rath, Victor Chen, Tiffany Huang, Shubin W. Shahab, Haritha Kunhiraman, James Ross, Gabrielle A. Price, Abhinav Dey, Dolores Hambardzumyan, Tobey MacDonald, David S. Yu, Christopher C. Porter, Anna M. Kenney
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/ff47403e1e7249699d95fc35ba65c551
Autor:
Eva Proestler, Julia Donzelli, Sheila Nevermann, Kai Breitwieser, Leon F. Koch, Tatjana Best, Maria Fauth, Malin Wickström, Patrick N. Harter, Per Kogner, Grégory Lavieu, Karin Larsson, Meike J. Saul
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Neuroblastoma is the most common extracranial solid tumor in childhood and arises from neural crest cells of the developing sympathetic nervous system. Prostaglandin E2 (PGE2) has been identified as a key pro-inflammatory mediator of the tumor microe
Externí odkaz:
https://doaj.org/article/dac53945b2fc4e109c405ee632c4379e
Autor:
Sabine M. Ulamec, Roberto Maya-Martinez, Emily J. Byrd, Katherine M. Dewison, Yong Xu, Leon F. Willis, Frank Sobott, George R. Heath, Patricija van Oosten Hawle, Vladimir L. Buchman, Sheena E. Radford, David J. Brockwell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors of this work characterize the effect of amino acid substitution on α-synuclein (α-Syn) aggregation. Residues 38 and 42 (in addition to 39) within the P1 region of α-Syn affect amyloid formation. The effect of substitution at position 3
Externí odkaz:
https://doaj.org/article/795dea3b15b941688aa5f281361c1332
Autor:
Liangping Yuan, Hongying Zhang, Jingbo Liu, Anshu Malhotra, Abhinav Dey, Bing Yu, Kishore Kumar Jella, Leon F. McSwain, Matthew J. Schniederjan, Tobey J. MacDonald
Publikováno v:
Molecular Oncology, Vol 16, Iss 4, Pp 1009-1025 (2022)
Sonic hedgehog (Shh)‐driven medulloblastoma (Shh MB) cells are dependent on constitutive Shh signaling, but targeted treatment of Shh MB has been ineffective due to drug resistance. The purpose of this study was to address the critical role of sign
Externí odkaz:
https://doaj.org/article/aef4e74286f14962b69a365a07945b57
Autor:
Benjamin J. Landis, Benjamin M. Helm, Jeremy L. Herrmann, Madeline C. Hoover, Matthew D. Durbin, Lindsey R. Elmore, Manyan Huang, Michael Johansen, Ming Li, Leon F. Przybylowski, Gabrielle C. Geddes, Stephanie M. Ware
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 19 (2022)
Background Our cardiac center established a systematic approach for inpatient cardiovascular genetics evaluations of infants with congenital heart disease, including routine chromosomal microarray (CMA) testing. This provides a new opportunity to inv
Externí odkaz:
https://doaj.org/article/40115732d18f4259bb543ce4c57ec276