Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Leon Eidels"'
Publikováno v:
Molecular Microbiology. 49:235-240
Whereas diphtheria and the mechanism of action of diphtheria toxin, the bacterial molecule that induces the disease, have been studied and understood for some time, the receptor that allows animal cells to bind the toxin escaped identification until
Publikováno v:
Infection and Immunity. 70:2344-2350
Although equine diphtheria antitoxin may be an effective therapy for human diphtheria, its use often induces serum sickness. We describe here a strategy for developing an alternative treatment based on the human diphtheria toxin (DT) receptor/heparin
Publikováno v:
Journal of Biological Chemistry. 275:6901-6907
Monkey (Mk) CD9 antigen has been shown previously to increase the diphtheria toxin (DT) sensitivity of cells when co-expressed with Mk proHB-EGF (DT receptor). We have elucidated here the mechanism whereby Mk CD9 influences Mk proHB-EGF and present e
Publikováno v:
Molecular Microbiology. 29:1275-1284
Summary The transmembrane precursor of the monkey (Mk) heparin-binding, epidermal growth factor-like growth factor (proHB-EGF) functions as a diphtheria toxin (DT) receptor, whereas the mouse (Ms) precursor does not. Previously, using chimeric Ms/Mk
Autor:
Leon Eidels, Kyle P. Hooper
Publikováno v:
Biochemical and Biophysical Research Communications. 220:675-680
The transmembrane precursor of the monkey heparin-binding EGF-like growth factor also functions as a diphtheria toxin receptor. The mouse precursor does not bind the toxin. Previously, the most important region for binding the toxin in the monkey pre
Autor:
Leon Eidels, Brian D. Almond
Publikováno v:
Molecular Microbiology. 18:623-630
Diphtheria toxin enters toxin-sensitive mammalian cells by receptor-mediated endocytosis employing the heparin-binding EGF-like growth factor precursor as its receptor. We reported previously (Almond and Eidels, 1994) that cytoplasmic domain mutants
Autor:
James E. Galen, Oscar G. Gómez-Duarte, Rino Rappuoli, Myron M. Levine, Leon Eidels, Steven N. Chatfield
Publikováno v:
Vaccine. 13:1596-1602
We report the expression of fragment C of tetanus toxin (FC) fused to the eukaryotic cell binding domain (the carboxyl-terminus) of diphtheria toxin (FC-bDt fusion) in attenuated Salmonella typhi live vector vaccine strain CVD 908. The FC-bDt protein
Publikováno v:
Proceedings of the National Academy of Sciences. 90:8184-8188
DTS-II is a highly diphtheria toxin (DT)-sensitive cell line previously isolated by transfection of wild-type DT-resistant mouse L-M(TK-) cells with the cDNA encoding a monkey Vero cell DT receptor. DTS-II cells are as toxin-sensitive as Vero cells,
Autor:
John M. Rolf, Leon Eidels
Publikováno v:
Molecular Microbiology. 7:585-591
The carboxyl-terminal region of diphtheria toxin (DT) has been analysed in order to determine regions of receptor recognition. Biochemical cleavage of the toxin with hydroxylamine (HA) was used to generate the peptides HA9DT (residues 454-535), HA6DT
Publikováno v:
Cell. 69:1051-1061
A monkey cDNA (pDTS) encoding a diphtheria toxin (DT) sensitivity determinant was isolated by expression cloning in mouse L-M cells. Mouse cells are naturally resistant to DT, because they lack functional cell surface receptors for the toxin. Unlike