Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Leon Earl Gray"'
Autor:
Leon Earl Gray, Nicola Evans, Christy S. Lambright, Bethany R. Hannas, Justin M. Conley, Johnathan Furr, Hunter Sampson, Vickie S. Wilson, Paul M. D. Foster
Publikováno v:
Toxicol Sci
Previously, we demonstrated that exposure to some diortho-phthalate esters during sexual differentiation disrupts male reproductive development by reducing fetal rat testis testosterone production (T Prod) and gene expression in a dose-related manner
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 188(2)
Administration of individual chemicals and mixtures during sexual differentiation that disrupt the androgen signaling pathway can induce reproductive abnormalities in male rats. In this study, we coadministered the heptafluoroisopropyl pesticide pyri
Autor:
Christy S. Lambright, Phillip C. Hartig, Mary C. Cardon, Nicola Evans, Paul M. D. Foster, Vickie S. Wilson, Leon Earl Gray, Johnathan Furr, Justin M. Conley
Publikováno v:
Toxicological Sciences. 168:632-643
Chemicals that disrupt androgen receptor (AR) function in utero induce a cascade of adverse effects in male rats including reduced anogenital distance, retained nipples, and reproductive tract malformations. The objective of this study was to compare
Autor:
Andrew K. Hotchkiss, Mary C. Cardon, Vickie S. Wilson, Nicola Evans, Phillip C. Hartig, Leon Earl Gray, Johnathan Furr, Christy S. Lambright, Justin M. Conley
Publikováno v:
Toxicol Sci
Multiple molecular initiating events exist that disrupt male sexual differentiation in utero including androgen receptor (AR) antagonism and inhibition of synthesis, and metabolism of fetal testosterone. Disruption of androgen signaling by AR antagon
Autor:
Leon Earl Gray
Publikováno v:
Current Opinion in Toxicology. 3:40-47
The aim of this paper is to provide the reader with a view of the Endocrine Disruptor Chemical (EDC) research field and its relevance to human health. My perspective is from working on the effects of EDCs that act via the androgen (A) or estrogen (E)
Autor:
Christy S. Lambright, Nicola Evans, Vickie S. Wilson, Leon Earl Gray, Johnathan Furr, Mary C. Cardon, Justin M. Conley
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 164(1)
Biomonitoring efforts have clearly shown that all humans are exposed to chemical mixtures. Of concern is whether or not exposure to mixtures during pregnancy contributes to congenital abnormalities in children even when each chemical is at an individ
Publikováno v:
Toxicological Sciences. 140:403-424
This study was designed to develop and validate a short-term in vivo protocol termed the Fetal Phthalate Screen (FPS) to detect phthalate esters (PEs) and other chemicals that disrupt fetal testosterone synthesis and testis gene expression in rats. W
Autor:
Christy S. Lambright, Vickie S. Wilson, Leon Earl Gray, Bethany R. Hannas, Kembra L. Howdeshell, Johnathan Furr
Publikováno v:
Toxicological Sciences. 123:206-216
Several phthalate esters have been linked to the Phthalate Syndrome, affecting male reproductive development when administered to pregnant rats during in utero sexual differentiation. The goal of the current study was to enhance understanding of this
Publikováno v:
Toxicological Sciences. 116:477-487
Exposure to xenoestrogens occurs against a backdrop to physiological levels of endogenous estrogens. Endogenous estrogen levels vary from low levels in early childhood to high levels during pregnancy and in young women. However, few studies have addr
Publikováno v:
International Journal of Andrology. 33:443-462
Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 Food Quality Protection Act required the US Environmental Protection Agency to consider cumulative risk of chemicals that act via a common mechanism of toxici