Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Leon D. Kluskens"'
Autor:
Ivone M. Martins, Alexandre Lima, Wim de Graaff, Joana S. Cristóvão, Niek Brosens, Eleonora Aronica, Leon D. Kluskens, Cláudio M. Gomes, Joana Azeredo, Helmut W. Kessels
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-8 (2024)
Abstract Oligomeric clusters of amyloid-β (Aβ) are one of the major biomarkers for Alzheimer’s disease (AD). However, proficient methods to detect Aβ-oligomers in brain tissue are lacking. Here we show that synthetic M13 bacteriophages displayin
Externí odkaz:
https://doaj.org/article/2e0eb88b678d4731b983a499182ac95e
Autor:
Hugo eOliveira, Diana eVilas Boas, Stéphane eMesnage, Leon D. Kluskens, Rob eLavigne, Sanna eSillankorva, Francesco eSecundo, Joana eAzeredo
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
The present study demonstrates the antibacterial potential of a phage endolysin against Gram-negative pathogens, particularly on A. baumannii multidrug resistant strains. We have cloned, heterologously expressed and characterized a novel endolysin (A
Externí odkaz:
https://doaj.org/article/7ce17eb5b00c454eab09df6879049038
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Externí odkaz:
https://doaj.org/article/5469b7ca62b24fb9937d4350669d48ac
Autor:
Vera L Silva, Debora Ferreira, Franklin L Nobrega, Ivone M Martins, Leon D Kluskens, Ligia R Rodrigues
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161290 (2016)
The use of bacteriophages to select novel ligands has been widely explored for cancer therapy. Their application is most warranted in cancer subtypes lacking knowledge on how to target the cancer cells in question, such as the triple negative breast
Externí odkaz:
https://doaj.org/article/4bc14f04d2e64bd9bb4b2178f7e40875
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136331 (2015)
Externí odkaz:
https://doaj.org/article/17f6696756ac4e00ab2479aaaa379342
Autor:
Ana Oliveira, Marta Leite, Leon D. Kluskens, Sílvio B. Santos, Luís D. R. Melo, Joana Azeredo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 8, p e0136331 (2015)
PLoS ONE, Vol 10, Iss 8, p e0136331 (2015)
Endolysins, which are peptidoglycan-degrading enzymes expressed during the terminal stage of the reproduction cycle of bacteriophages, have great potential to control Gram-positive pathogens. This work describes the characterization of a novel endoly
Autor:
Thijs Kaper, CornéH Verhees, Joyce H.G Lebbink, Johan F.T van Lieshout, Leon D Kluskens, Don E Ward, Serve W.M Kengen, Marks M Beerthuyzen, Willem M de Vos, John van der Oost
Publisher Summary Enzymes from bacterial and archaeal hyperthermophiles have been studied extensively for their catalytic properties and stability at extremely high temperatures, as well as their biotechnological potential as biocatalysts at elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b35199785aeff361d38c00a22c62ab9
https://doi.org/10.1016/s0076-6879(01)30386-5
https://doi.org/10.1016/s0076-6879(01)30386-5
Autor:
Hugo Oliveira, Viruthachalam Thiagarajan, Maarten Walmagh, Sanna Sillankorva, Rob Lavigne, Maria Teresa Neves-Petersen, Leon D Kluskens, Joana Azeredo
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108376 (2014)
Resistance rates are increasing among several problematic Gram-negative pathogens, a fact that has encouraged the development of new antimicrobial agents. This paper characterizes a Salmonella phage endolysin (Lys68) and demonstrates its potential an
Externí odkaz:
https://doaj.org/article/524da4c01f554ece9d8cc8894a1ae118