Výsledky vyhledávání - "Leon C, King"

Association between mutation spectra and stable and unstable DNA adduct profiles in Salmonella for benzo[a]pyrene and dibenzo[a,l]pyrene

Autor: David M. DeMarini, Nancy M. Hanley, Sarah H. Warren, Linda D. Adams, Leon C. King

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 714:17-25

Benzo[a]pyrene (BP) and dibenzo[a,l]pyrene (DBP) are two polycyclic aromatic hydrocarbons (PAHs) that exhibit distinctly different mutagenicity and carcinogenicity profiles. Although some studies show that these PAHs produce unstable DNA adducts, con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6991b0623e43840e79741818c4769be
https://doi.org/10.1016/j.mrfmmm.2011.06.003

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Assessment of multiple types of DNA damage in human placentas from smoking and nonsmoking women in the Czech Republic

Autor: Miriam C. Poirier, Radim J. Sram, Ofelia A. Olivero, David M. DeMarini, Linda D. Adams, Paul Sirajuddin, M. Margaret Pratt, David K. Manchester, Kaarthik John, Leon C. King

Publikováno v: Environmental and Molecular Mutagenesis. 52:58-68

Three classes of DNA damage were assessed in human placentas collected (2000–2004) from 51 women living in the Teplice region of the Czech Republic, a mining area considered to have some of the worst environmental pollution in Europe in the 1980s.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9783c035a8dbbaad8817e0cea616e7a9
https://doi.org/10.1002/em.20581

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Mutagenicity, stable DNA adducts, and abasic sites induced in Salmonella by phenanthro[3,4-b]- and phenanthro[4,3-b]thiophenes, sulfur analogs of benzo[c]phenanthrene

Autor: Carol D, Swartz, Leon C, King, Stephen, Nesnow, David M, Umbach, Subodh, Kumar, Harish, Sikka, David M, Demarini

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 661:47-56

Sulfur-containing polycyclic aromatic hydrocarbons (thia-PAHs or thiaarenes) are common constituents of air pollution and cigarette smoke, but only a few have been studied for health effects. We evaluated the mutagenicity in Salmonella TA98, TA100, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3458e77956e8b05bffff9f015be29986
https://doi.org/10.1016/j.mrfmmm.2008.11.001

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Identification of 5-(Deoxyguanosin-N2-yl)- 1,2-dihydroxy-1,2-dihydro-6-aminochrysene as the Major DNA Lesion in the Mammary Gland of Rats Treated with the Environmental Pollutant 6-Nitrochrysene

Autor: Shantu Amin, William T. Padgett, Telih Boyiri, Arun Sharma, Jyh Ming Lin, Karam El-Bayoumy, Guy R. Lambert, Stephen Nesnow, Leon C. King, Jacek Krzeminski

Publikováno v: Chemical Research in Toxicology. 17:1591-1599

The environmental pollutant 6-nitrochrysene (6-NC) is a potent carcinogen in several animal models including the rat mammary gland. 6-NC can be activated to intermediates that can damage DNA by simple nitroreduction, ring oxidation, or a combination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a29c4887c0d35bba1112d1e559250c12
https://doi.org/10.1021/tx049849+

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An Evaluation of the Mutagenicity, Metabolism, and DNA Adduct Formation of 5-Nitrobenzo[b]naphtho[2,1-d]thiophene

Autor: Stephen Nesnow, William T. Padgett, Dhimant Desai, Guy R. Lambert, Joycelyn Allison, Michael J. Kohan, Leon C. King, and Ann M. Richard, Garret B. Nelson, L. R. Brooks, Jeffrey A. Ross, Shantu Amin, Linda D. Adams

Publikováno v: Chemical Research in Toxicology. 14:661-671

Thioarenes, sulfur-containing polycyclic aromatic compounds, are environmental contaminants suspected of posing human health risks. In this study, 5-nitrobenzo[b]naphtho[2,1-d]thiophene (5-nitro-BNT), a nitrated-thioarene, was examined for its mutage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92318ebe236581ec83e5978c6b643e3b
https://doi.org/10.1021/tx0001373

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Biotransformation and DNA Adduct Formation ofTrans-8,9-Dihydroxy-8,9-Dihydrodibenzo[a, l]Pyrene by Induced Rat Liver and Human CYP1A1 Microsomes

Autor: Stephen Nesnow, Leon C. King, C. Davis, Guy R. Lambert, Michael H. George, William T. Padgett, Linda D. Adams

Publikováno v: Polycyclic Aromatic Compounds. 16:181-190

In order to explain the adduct patterns observed from the human CYP1A1-mediated binding of dibenzo[a, l]pyrene (DB[a, l]P) to DNA, we have investigated the further metabolism and DNA adduct activity of trans-DB[a, l]P-8,9-diol by induced rat liver an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b95733bad2ab792c70739d457782f0ad
https://doi.org/10.1080/10406639908020585

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8,9-Dihydroxy-8,9-dihydrodibenzo[ a , l ]pyrene is a potent morphological cell-transforming agent in C3H10T 1 / 2 Cl8 mouse embryo fibroblasts in the absence of detectable stable covalent DNA adducts

Autor: William T. Padgett, C. Davis, Leon C. King, Stephen Nesnow, Michele Yacopucci, Linda D. Adams

Publikováno v: Carcinogenesis. 21:1253-1257

The comparative genotoxic effects of racemic trans-8,9-dihydroxy-8, 9-dihydrodibenzo[a,l]pyrene (trans-DB[a,l]P-8,9-diol), the metabolic K-region dihydrodiol of dibenzo[a,l] pyrene (DB[a,l]P) (dibenzo[def, p]chrysene) and DB[a,l]P in transformable mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adc70ed3f1d2affd62256cbf0785baa
https://doi.org/10.1093/carcin/21.6.1253

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A quantitative comparison of dibenzo[a,l]pyrene-DNA adduct formation by recombinant human cytochrome P450 microsomes

Autor: Jeffrey A. Ross, Joycelyn Allison, Michael J. Kohan, Dhimant Desai, Leon C. King, Shantu Amin, Garret B. Nelson, Linda D. Adams

Publikováno v: Molecular Carcinogenesis. 26:74-82

Dibenzo[a,l]pyrene (DB[a,l]P), an extremely potent environmental carcinogen, is metabolically activated in mammalian cells and microsomes through the fjord-region dihydrodiol, trans-DB[a,l]P-11, 12-diol, to syn- and anti-DB[a,l]P-11,12-diol-13,14-epo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b5eaf91fadcf6062083e72e6b151e68
https://doi.org/10.1002/(sici)1098-2744(199910)26:2<74::aid-mc2>3.0.co

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Comparative time-course of benzo[a]pyrene-DNA adduct formation, and its relationship to CYP1A activity in two species of catfish

Autor: R. T. Di Giulio, S.A. Ploch, Leon C. King

Publikováno v: Marine Environmental Research. 46:345-349

Studies have demonstrated differences between the brown bullhead (Ameriurus nebulosus) (BB) and a closely related species of catfish, the channel catfish (Ictalurus punctatus) (CC) in activity of important liver enzymes that may affect their ability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::195beae98a01f6b2c040015505579dce
https://doi.org/10.1016/s0141-1136(97)00118-9

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