Výsledky vyhledávání - "Leon A. G. M. Van den Broek"

1,3-Dipolar cycloaddition reactions of homochiral cyclic nitrones derived from 1-deoxynojirimycin

Publikováno v: Tetrahedron. 52:4467-4478

The synthesis of nitrones 12, 19 and 20 , derived from 1-deoxynojirimycin ( 1 , dNM), using 2,2-dimethyldioxirane, is reported. In subsequent 1,3-dipolar cycloaddition reactions of nitrones 12 and 19 with phenyl isocyanate and trichloro acetonitrile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8745da23d090028743b8da320905b479
https://doi.org/10.1016/0040-4020(96)00094-4

Zobrazit plný text záznamu

Introduction of oxygen into the alkyl chain of N-decyl-dNM decreases lipophilicity and results in increased retention of glucose residues on N-linked oligosaccharides

Autor: Leon A. G. M. Van Den Broek, Agnes Tan, Hidde L. Ploegh, Liesbeth Pastoors, J G Bolscher, Dirk Jan Vermass, Constant A. A. van Boeckel

Publikováno v: Glycobiology. 4:141-149

N-Alkylation of the alpha-glucosidase inhibitor 1-deoxynojirimycin (dNM) dramatically increases its inhibitory potency (Tan et al., J. Biol. Chem., 266, 14504-14510, 1991). However, the possibility of extending the alkyl chain to N-decyl-dNM is limit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1572ce107870d078a27355606f294c
https://doi.org/10.1093/glycob/4.2.141

Zobrazit plný text záznamu

Structure-activity relationships of sparsomycin: modification at the hydroxyl group

Autor: Leon A. G. M. van den Broek, Peter Lelieveld, Harry C. J. Ottenheijm, Juan P. G. Ballesta, Ester Lázaro

Publikováno v: Biochimie. 69:849-856

Ten analogues of the antibiotic sparsomycin were prepared and evaluated in several in vitro tests. Nine of them carry a modification at the hydroxymethylene group of the molecules, two have a disulfide bond instead of the S(O)-CH 2 -S moiety at the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90224407584839dc2cf6d5ac8dcbc08
https://doi.org/10.1016/0300-9084(87)90211-2

Zobrazit plný text záznamu

Total synthesis and absolute configuration of the natural dipeptide .gamma.-glutamylmarasmine

Autor: Harry C. J. Ottenheijm, Marco L. Breuer, Rob M. J. Liskamp, Leon A. G. M. van den Broek

Publikováno v: The Journal of Organic Chemistry. 52:1511-1517

Synthese du S-oxyde de γ-glutamyl S-methylthiomethyl alanine (γ-glutamylmarasmine) et de son epimere sulfoxyde; configuration absolue a l'aide de dichroisme circulaire et du signe de l'effet Cotton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ae64239c715d8454822c8d14ccb733b
https://doi.org/10.1021/jo00384a024

Zobrazit plný text záznamu

Synthesis of tritium labelled sparsomycin

Autor: Leon A. G. M. van den Broek, Kitty C. M. W. Willemsen, Harry C. J. Ottenheijm, Frans M. Kaspersen, Irene H. G. Schlachter

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 27:583-588

The synthesis is described of tritiated sparsomycin (5), a broad-spectrum antitumor antibiotic, with high specific activity (31.4 Ci/mmol, 1.16 TBq/mmol). The radiolabel was introduced by reduction of the cysteine methyl ester 1 with lithium borotrit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::883393d6aeebed8092ecce16a01ac6ee
https://doi.org/10.1002/jlcr.2580270512

Zobrazit plný text záznamu

Pharmacokinetics and toxicology of sparsomycin in beagle dogs

Autor: D. J. Theo Wagener, Benjamin Winograd, Leon A. G. M. van den Broek, Harry C. J. Ottenheijm, Eppo van der Kleijn, Tom B. Vree, Zbigniew Zylicz, Helga van Rennes, Urbanus van Haelst, J. M. C. Wessels, Pilar Fernandez del Moral

Publikováno v: Cancer Chemotherapy and Pharmacology. 20:115-124

Sparsomycin is a cytotoxic drug exhibiting a broad spectrum of in vitro activity against murine tumors and many tumor cell lines. It also appears to be a potent stimulator of the antitumor activity of cisplatin against L1210 leukemia in vivo. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99c53fe4576cd57f8a6ef2f34cad5bb
https://doi.org/10.1007/bf00253964

Zobrazit plný text záznamu

The role of the hydroxymethyl function on the biological activity of the antitumor antibiotic sparsomycin

Autor: Peter Lelieveld, Paul J. Fennis, Harry C. J. Ottenheijm, Juan P. G. Ballesta, Leon A. G. M. van den Broek, Ester La´zaro, M. Arévalo

Publikováno v: European Journal of Medicinal Chemistry. 24:503-510

The synthesis is described of the sparsomycin analogues11–14 from the l -amino acids valine, isoleucine, phenylalanine and proline, respectively. The sparsomycin derivative 21 was not prepared in a similar way from glycine, but from cystamine follo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78afafc60838712a6f444f9018af66ce
https://doi.org/10.1016/0223-5234(89)90055-x

Zobrazit plný text záznamu

Characterization of the hamster desmin gene: expression and formation of desmin filaments in nonmuscle cells after gene transfer

Autor: Leon A. G. M. van den Broek, Hans Bloemendal, Wilma Vree Egberts, Wim J. Quax, Frans C. S. Ramaekers

Publikováno v: Cell. 43(1)

The structural organization of the hamster gene encoding the intermediate filament (IF) protein desmin has been determined. The gene, 6.5 kb in length, contains nine exons with a total length of 2169 nucleotides. Remarkably, the intervening sequences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18be8d51e796b0bb24f90d74864e32c
https://pubmed.ncbi.nlm.nih.gov/3855248

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání