Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.

Autor: Hoi DM; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria; Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, 1030 Vienna, Austria; University of Vienna, Center for Molecular Biology, Department for Biochemistry and Cell Biology, 1030 Vienna, Austria., Junker S; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria., Junk L; Saarland University, Organic Chemistry I, 66123 Saarbrücken, Germany; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbrücken, Germany. Electronic address: lukas.junk@helmholtz-hips.de., Schwechel K; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany., Fischel K; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria., Podlesainski D; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany., Hawkins PME; School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, NSW 2006, Australia., van Geelen L; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany., Kaschani F; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany., Leodolter J; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria., Morreale FE; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria., Kleine S; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany., Guha S; Saarland University, Organic Chemistry I, 66123 Saarbrücken, Germany., Rumpel K; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria., Schmiedel VM; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria., Weinstabl H; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria., Meinhart A; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria., Payne RJ; School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, NSW 2006, Australia., Kaiser M; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany., Hartl M; Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria; University of Vienna, Center for Molecular Biology, Department for Biochemistry and Cell Biology, 1030 Vienna, Austria., Boehmelt G; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria., Kazmaier U; Saarland University, Organic Chemistry I, 66123 Saarbrücken, Germany; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbrücken, Germany., Kalscheuer R; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany., Clausen T; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria; Medical University of Vienna, 1030 Vienna, Austria. Electronic address: tim.clausen@imp.ac.at.

Publikováno v: Cell [Cell] 2023 May 11; Vol. 186 (10), pp. 2176-2192.e22. Date of Electronic Publication: 2023 May 02.

ClpC2 protects mycobacteria against a natural antibiotic targeting ClpC1-dependent protein degradation.

Autor: Taylor G; ETH Zurich, Institute of Molecular Biology & Biophysics, CH-8093, Zurich, Switzerland., Cui H; ETH Zurich, Institute of Molecular Biology & Biophysics, CH-8093, Zurich, Switzerland., Leodolter J; ETH Zurich, Institute of Molecular Biology & Biophysics, CH-8093, Zurich, Switzerland.; Research Institute of Molecular Pathology (IMP), Vienna, Austria., Giese C; ETH Zurich, Institute of Molecular Biology & Biophysics, CH-8093, Zurich, Switzerland., Weber-Ban E; ETH Zurich, Institute of Molecular Biology & Biophysics, CH-8093, Zurich, Switzerland. eilika@mol.biol.ethz.ch.

Publikováno v: Communications biology [Commun Biol] 2023 Mar 21; Vol. 6 (1), pp. 301. Date of Electronic Publication: 2023 Mar 21.

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.

Autor: Hajdusits B; Research Institute of Molecular Pathology (IMP), Vienna BioCenter, Vienna, Austria., Suskiewicz MJ; Research Institute of Molecular Pathology (IMP), Vienna BioCenter, Vienna, Austria., Hundt N; Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom., Meinhart A; Research Institute of Molecular Pathology (IMP), Vienna BioCenter, Vienna, Austria.; Medical University of Vienna, Vienna, Austria., Kurzbauer R; Research Institute of Molecular Pathology (IMP), Vienna BioCenter, Vienna, Austria., Leodolter J; Research Institute of Molecular Pathology (IMP), Vienna BioCenter, Vienna, Austria., Kukura P; Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom., Clausen T; Research Institute of Molecular Pathology (IMP), Vienna BioCenter, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.

Publikováno v: ELife [Elife] 2021 Jul 30; Vol. 10. Date of Electronic Publication: 2021 Jul 30.

Breaking Bad Proteins—Discovery Approaches and the Road to Clinic for Degraders.

Autor: Bouvier, Corentin¹ (AUTHOR) corentin.bouvier@lcc-toulouse.fr, Lawrence, Rachel² (AUTHOR) f.cavallo@sygnaturediscovery.com, Cavallo, Francesca² (AUTHOR) a.jordan@sygnaturediscovery.com, Xolalpa, Wendy³ (AUTHOR) wendy.xolalpa@ibt.unam.mx, Jordan, Allan² (AUTHOR), Hjerpe, Roland² (AUTHOR) r.hjerpe@sygnaturediscovery.com, Rodriguez, Manuel S.^1,4,5 (AUTHOR) manuel.rodriguez@lcc-toulouse.fr

Publikováno v: Cells (2073-4409). Apr2024, Vol. 13 Issue 7, p578. 37p.

BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery.

Autor: Bonjorno, Andressa Francielli¹, Pavan, Aline Renata^1,2, Fernandes, Guilherme F. S.³, Scarim, Caue Benito¹, Castagnolo, Daniele³, Dos Santos, Jean Leandro¹ jean.santos@unesp.br, Salih, Mohammed, Kavanagh, Madeline E.

Publikováno v: Frontiers in Chemistry. 2024, p1-6. 6p.