Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Leock Y. Ngo"'
Autor:
Ryan Edbert Husni, Leock Y. Ngo, Hirofumi Senokuchi, Anna Patten, Hidetaka Hiramatsu, Kazuaki Watanabe, Takamichi Yamamoto
Publikováno v:
Epilepsia Open, Vol 7, Iss 1, Pp 59-66 (2022)
Abstract Objective This post hoc analysis evaluated whether continued treatment with perampanel monotherapy beyond initial titration may be appropriate for patients with focal‐onset seizures (FOS) with currently untreated epilepsy to achieve seizur
Externí odkaz:
https://doaj.org/article/05f6687e738646d495daecb6ca4d956e
Intravenous perampanel as an alternative to the oral formulations in Japanese patients with epilepsy
Autor:
Ryosuke Hanaya, Yuichi Kubota, Masahiro Mizobuchi, Koji Iida, Tomonori Ono, Hiromichi Motooka, Naoki Nakano, Ayataka Fujimoto, Masaki Iwasaki, Masafumi Fukuda, Akihiko Kondo, Katsuhisa Uruno, Shintaro Yamamuro, Kohei Yamaguchi, Kisaki Onishi, Leock Y Ngo, Yushi Inoue
Publikováno v:
Epilepsia Open, Vol 8, Iss 4, Pp 1369-1382 (2023)
Abstract Objective Perampanel is an oral anti‐seizure medication, which is approved in Japan for focal‐onset seizures, with/without focal to bilateral tonic–clonic seizures, as monotherapy/adjunctive therapy in patients aged 4 years and older.
Externí odkaz:
https://doaj.org/article/d4e415cc099a4f0782e716075c0be65b
Autor:
Hidetaka Hiramatsu, Anna Patten, Kazuaki Watanabe, Hirofumi Senokuchi, Ryan Edbert Husni, Leock Y. Ngo, Takamichi Yamamoto
Publikováno v:
Epilepsia Open. 7:59-66
OBJECTIVE This post hoc analysis evaluated whether continued treatment with perampanel monotherapy beyond initial titration may be appropriate for patients with focal-onset seizures (FOS) with currently untreated epilepsy to achieve seizure freedom w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c8b531602ab35b98d609769e551b1c
https://doi.org/10.1002/epi4.12551
https://doi.org/10.1002/epi4.12551
Autor:
Wesley T. Kerr, Christian Brandt, Leock Y. Ngo, Anna Patten, Jocelyn Y. Cheng, Lynn Kramer, Jacqueline A. French
Publikováno v:
EpilepsiaREFERENCES. 63(11)
To evaluate the exploratory time to exceed pre-randomization seizure count (T-PSC) in the determination of efficacy of adjunctive perampanel in participants with primary generalized tonic-clonic (PGTC) seizures in generalized-onset epilepsy.In this m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b8c37d6eee89fc798f18e7d04415fd
https://pubmed.ncbi.nlm.nih.gov/36106379
https://pubmed.ncbi.nlm.nih.gov/36106379
Publikováno v:
Clinical pharmacology in drug development. 11(7)
Intravenous (IV) drug administration enables treatment of epilepsy when oral administration is temporarily not feasible. Perampanel is a once-daily antiseizure medication currently available as oral formulations. Study 050 (NCT03376997) was an open-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488dfd6ee5baaa7045dcbbaed5d73da8
https://pubmed.ncbi.nlm.nih.gov/35596529
https://pubmed.ncbi.nlm.nih.gov/35596529
Autor:
Robert Wechsler, Antonietta Coppola, Anshu Rohatgi, Anna Patten, Samantha Goldman, Anna Gentile, Balaji Patil, Amitabh Dash, Leock Y Ngo, Manoj Malhotra
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 93:e2.17
BackgroundWe report data from three Phase IV, observational studies (Studies 506 [US;NCT03208660], 508 [India;NCT03836924] and 501 [Italy;NCT04257604]), which assessed real-world safety and efficacy of adjunctive perampanel across different regions.M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca5879043b629195e65a7f811a4305e6
https://doi.org/10.1136/jnnp-2022-abn2.113
https://doi.org/10.1136/jnnp-2022-abn2.113
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 93:A105.2-A105
BackgroundThis post hoc analysis assessed the efficacy and safety of adjunctive perampanel in adult/adolescent/paediatric patients with myoclonic and absence seizures during Phase II/III clinical studies.MethodsDuring Study 332 (NCT01393743), patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b009a203a1348cdb33cfb0902d65f0c5
https://doi.org/10.1136/jnnp-2022-abn.339
https://doi.org/10.1136/jnnp-2022-abn.339
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 93:A57.3-A58
BackgroundThe long-term (≤1-year) effects of adjunctive perampanel on cognition, behaviour and growth/development were assessed in paediatric patients aged 4–NCT02849626).MethodsCore Study (4-week pretreatment/23-week treatment) completers could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0df4bde4a40879eb11a5b5071dbe446
https://doi.org/10.1136/jnnp-2022-abn.185
https://doi.org/10.1136/jnnp-2022-abn.185
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 93:A105.3-A105
BackgroundLong-term (1-year) seizure-freedom rates with adjunctive perampanel were assessed in paediatric patients aged 4–NCT02849626).MethodsSeizure-freedom rates (FOS, FBTCS, GTCS) were assessed in patients who achieved seizure freedom during the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0deb1e98c9e09e10a177d49128614fd5
https://doi.org/10.1136/jnnp-2022-abn.340
https://doi.org/10.1136/jnnp-2022-abn.340
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 93:A105.4-A106
BackgroundThe long-term efficacy and safety of adjunctive perampanel was evaluated in patients aged≥60 years with focal-onset seizures (FOS) with/without focal to bilateral tonic-clonic seizures (FBTCS) who participated in open-label extension Stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1b9da5c23e53cd30b147b1219e522b7
https://doi.org/10.1136/jnnp-2022-abn.341
https://doi.org/10.1136/jnnp-2022-abn.341