Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Leo Zhang"'
Autor:
Jimmy Lee, Liang Leo Zhang, Wenjun Wu, Hui Guo, Yan Li, Madina Sukhanova, Girish Venkataraman, Hui Zhang, Mir Alikhan, Pin Lu, Ailin Guo, Natalie Galanina, Jorge Andrade, Michael L. Wang, Y. Lynn Wang
Publikováno v:
Blood Advances, Vol 2, Iss 16, Pp 2039-2051 (2018)
Abstract: The BTK inhibitor ibrutinib has demonstrated a remarkable therapeutic effect in mantle cell lymphoma (MCL). However, approximately one-third of patients do not respond to the drug initially. To identify the mechanisms underlying primary ibr
Externí odkaz:
https://doaj.org/article/a15f163217104838a6c52f480e8b1a38
Autor:
Michael Wang, Leo Zhang, Krystle Nomie, Richard J. Ford, L. Jeffrey Medeiros, Ken H. Young, R. Eric Davis, Jason Westin, Laura Lam, Zhiyong Ding, Elizabeth Pogue, Shouhao Zhou, Taylor Bell, Jun Zhang, Hui Zhang, Shengjian Huang, Lan V. Pham
Cell viability assays were performed using the Celltiter-Glo Luminescent Cell Viability Assay in representative MCL primary cells (PT-2 and PT-6) treated with increasing concentrations of ibrutinib (A) or idelalisib (B).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7a602fb47b0626e353bec1ffeef0f3
https://doi.org/10.1158/1078-0432.22467461.v1
https://doi.org/10.1158/1078-0432.22467461.v1
Autor:
Michael Wang, Leo Zhang, Krystle Nomie, Richard J. Ford, L. Jeffrey Medeiros, Ken H. Young, R. Eric Davis, Jason Westin, Laura Lam, Zhiyong Ding, Elizabeth Pogue, Shouhao Zhou, Taylor Bell, Jun Zhang, Hui Zhang, Shengjian Huang, Lan V. Pham
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e72bf71862743c8074acf2bea9f8547
https://doi.org/10.1158/1078-0432.22467452.v1
https://doi.org/10.1158/1078-0432.22467452.v1
Autor:
Michael Wang, Y. Lynn Wang, Qing Yi, Laura Lam, Yiping Shao, Steven Y. Huang, Selvi Thirumurthi, Makhdum Ahmed, Maria Badillo, Lei Li, Jacqueline Wang, Bingliang Fang, Jack Wang, Carrie Li, Wenjing Tao, Zhihong Chen, Hui Guo, Shengjian Huang, Yang Liu, Onyekachukwu Oriabure, Wendy Chen, Shruti Sharma, Shawana Richard, David Santos, Shouhao Zhou, Shaoying Li, Jeremy Segal, Sabah Kadri, Lan Pham, Taylor Bell, Hui Zhang, Krystle Nomie, Leo Zhang
A, Schematic describing the primary B-cell lymphoma PDX SCID/NSG-hu mouse model. Six-to 8-week-old male NSG or CB-17 SCID mice were implanted with human fetal bone. Approximately 4 to 6 weeks following bone implantation, one injection of 5 Ã- 106 pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f40caed24f874830da4da33c8347e6
https://doi.org/10.1158/1078-0432.22467500.v1
https://doi.org/10.1158/1078-0432.22467500.v1
Autor:
Michael Wang, Y. Lynn Wang, Qing Yi, Laura Lam, Yiping Shao, Steven Y. Huang, Selvi Thirumurthi, Makhdum Ahmed, Maria Badillo, Lei Li, Jacqueline Wang, Bingliang Fang, Jack Wang, Carrie Li, Wenjing Tao, Zhihong Chen, Hui Guo, Shengjian Huang, Yang Liu, Onyekachukwu Oriabure, Wendy Chen, Shruti Sharma, Shawana Richard, David Santos, Shouhao Zhou, Shaoying Li, Jeremy Segal, Sabah Kadri, Lan Pham, Taylor Bell, Hui Zhang, Krystle Nomie, Leo Zhang
Supplementary Table S3. OncoPlus Gene List and Identified Variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00955caaa55017914c5ab02f2bbf843e
https://doi.org/10.1158/1078-0432.22467479.v1
https://doi.org/10.1158/1078-0432.22467479.v1
Autor:
Michael Wang, Leo Zhang, Krystle Nomie, Richard J. Ford, L. Jeffrey Medeiros, Ken H. Young, R. Eric Davis, Jason Westin, Laura Lam, Zhiyong Ding, Elizabeth Pogue, Shouhao Zhou, Taylor Bell, Jun Zhang, Hui Zhang, Shengjian Huang, Lan V. Pham
Purpose: B-cell lymphoma-2 (BCL-2), an antiapoptotic protein often dysregulated in B-cell lymphomas, promotes cell survival and provides protection from stress. A recent phase I first-in-human study of the BCL-2 inhibitor venetoclax in non-Hodgkin ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb17020d3368e08c3ca37eb9a969995
https://doi.org/10.1158/1078-0432.c.6526646
https://doi.org/10.1158/1078-0432.c.6526646
Autor:
Michael Wang, Y. Lynn Wang, Qing Yi, Laura Lam, Yiping Shao, Steven Y. Huang, Selvi Thirumurthi, Makhdum Ahmed, Maria Badillo, Lei Li, Jacqueline Wang, Bingliang Fang, Jack Wang, Carrie Li, Wenjing Tao, Zhihong Chen, Hui Guo, Shengjian Huang, Yang Liu, Onyekachukwu Oriabure, Wendy Chen, Shruti Sharma, Shawana Richard, David Santos, Shouhao Zhou, Shaoying Li, Jeremy Segal, Sabah Kadri, Lan Pham, Taylor Bell, Hui Zhang, Krystle Nomie, Leo Zhang
PT8 was clinically primary ibrutinib resistant. PT8-MCL PDX was generated and passaged. G3 mice were treated with vehicle control, IBN, and CFZ (P < 0.01, CFZ versus vehicle control or IBN, n = 5).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078fc62c57f705b37b6e2346307d04be
https://doi.org/10.1158/1078-0432.22467491
https://doi.org/10.1158/1078-0432.22467491
Autor:
Michael Wang, Y. Lynn Wang, Qing Yi, Laura Lam, Yiping Shao, Steven Y. Huang, Selvi Thirumurthi, Makhdum Ahmed, Maria Badillo, Lei Li, Jacqueline Wang, Bingliang Fang, Jack Wang, Carrie Li, Wenjing Tao, Zhihong Chen, Hui Guo, Shengjian Huang, Yang Liu, Onyekachukwu Oriabure, Wendy Chen, Shruti Sharma, Shawana Richard, David Santos, Shouhao Zhou, Shaoying Li, Jeremy Segal, Sabah Kadri, Lan Pham, Taylor Bell, Hui Zhang, Krystle Nomie, Leo Zhang
Supplementary Table S2. The RPPA antibody list
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e74a6cab312b47fb3f78a905fbd3a4
https://doi.org/10.1158/1078-0432.22467482
https://doi.org/10.1158/1078-0432.22467482
Autor:
Michael Wang, Y. Lynn Wang, Qing Yi, Laura Lam, Yiping Shao, Steven Y. Huang, Selvi Thirumurthi, Makhdum Ahmed, Maria Badillo, Lei Li, Jacqueline Wang, Bingliang Fang, Jack Wang, Carrie Li, Wenjing Tao, Zhihong Chen, Hui Guo, Shengjian Huang, Yang Liu, Onyekachukwu Oriabure, Wendy Chen, Shruti Sharma, Shawana Richard, David Santos, Shouhao Zhou, Shaoying Li, Jeremy Segal, Sabah Kadri, Lan Pham, Taylor Bell, Hui Zhang, Krystle Nomie, Leo Zhang
Representative tumor mass and histology of tumor series passages of PT1 MCL and PT2 Burkitt's lymphoma (BL). B-C, PDX tumors invaded the mouse spleen and formed splenomegaly. D, Patient abdomen PET/CT images of PT1 and PT5 showed splenomegaly (left p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67c7f4bcd065c3119145bc3632d1eda
https://doi.org/10.1158/1078-0432.22467497
https://doi.org/10.1158/1078-0432.22467497
Autor:
Michael Wang, Y. Lynn Wang, Qing Yi, Laura Lam, Yiping Shao, Steven Y. Huang, Selvi Thirumurthi, Makhdum Ahmed, Maria Badillo, Lei Li, Jacqueline Wang, Bingliang Fang, Jack Wang, Carrie Li, Wenjing Tao, Zhihong Chen, Hui Guo, Shengjian Huang, Yang Liu, Onyekachukwu Oriabure, Wendy Chen, Shruti Sharma, Shawana Richard, David Santos, Shouhao Zhou, Shaoying Li, Jeremy Segal, Sabah Kadri, Lan Pham, Taylor Bell, Hui Zhang, Krystle Nomie, Leo Zhang
Purpose: Patients with B-cell lymphomas often relapse after frontline therapy, and novel therapies are urgently needed to provide long-term remission. We established B-cell lymphoma patient-derived xenograft (PDX) models to assess their ability to mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091115f99cda0b8dbadb4f0168d4c64f
https://doi.org/10.1158/1078-0432.c.6526658.v1
https://doi.org/10.1158/1078-0432.c.6526658.v1