Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Leo W, Barrett"'
Autor:
Paul L. Richardson, Victoria E. Scott, Marie E. Uchic, Larry Solomon, Edward T. Olejniczak, Karl A. Walter, Rachel Davis-Taber, Danying Song, Chaohong Sun, Leo W. Barrett, Ana Pereda-Lopez, Philip J. Hajduk, Marc R. Lake
Publikováno v:
Proceedings of the National Academy of Sciences. 104:7875-7880
The pituitary adenylate cyclase-activating polypeptide (PACAP) receptor is a class II G protein-coupled receptor that contributes to many different cellular functions including neurotransmission, neuronal survival, and synaptic plasticity. The soluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c62621b818f70dc9bd76d1e57a970e
https://doi.org/10.1073/pnas.0611397104
https://doi.org/10.1073/pnas.0611397104
Autor:
Patrick A, Marcotte, Paul L, Richardson, Paul R, Richardson, Jun, Guo, Leo W, Barrett, Nan, Xu, Angelo, Gunasekera, Keith B, Glaser
Publikováno v:
Analytical Biochemistry. 332:90-99
A novel fluorescent substrate was devised for the sirtuin (SIRT) class of human protein deacetylases comprised of a peptide sequence containing a single acetyl-lysine residue, with a fluorescent group (tetramethylrhodamine-6-carboxylic acid, 6-TAMRA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62dbbfd59263e0f60912bd0776ee540
https://doi.org/10.1016/j.ab.2004.05.039
https://doi.org/10.1016/j.ab.2004.05.039
Autor:
Larry R. Solomon, Joshua Bess, Yaya Liu, Leo W. Barrett, Paul L. Richardson, Chih-Ming Chen, Akhteruzzaman Molla, Rakesh Tripathi, Warren M. Kati, Ayda Saldivar, William E. Kohlbrenner
Publikováno v:
Biochemistry. 42:8862-8869
Indandiones were identified as a novel class of small molecule inhibitors of hepatitis C virus NS3 serine protease from high throughput screening. We further studied the structure activity relationships and the mechanisms of inhibition for this class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f345b641228a33d16c88b9aafdb912c5
https://doi.org/10.1021/bi034661v
https://doi.org/10.1021/bi034661v
Autor:
Steve Anderson, Akhter Molla, Robert J Carrick, Jeffrey R. Huth, Karl A. Walter, Leo W. Barrett, Robert P. Meadows, Kent D. Stewart, Dale J. Kempf, Paul L. Richardson, Clarence J. Maring, Vincent S. Stoll, Edmund D. Matayoshi, Teresa I. Ng, Edward T. Olejniczak, William E. Kohlbrenner, Renaldo Mendoza, Jean M. Severin, Hongmei Mo, Keith F. McDaniel, Rebecca Hutchinson
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(2)
The ectodomain of HIV-1 gp41 mediates the fusion of viral and host cellular membranes. The peptide-based drug Enfuvirtide 1 is precedent that antagonists of this fusion activity may act as anti HIV-agents. Here, NMR screening was used to discover non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5d850f797b63ddc2ee55406990346b
https://pubmed.ncbi.nlm.nih.gov/20004576
https://pubmed.ncbi.nlm.nih.gov/20004576
Autor:
Akhter Molla, Leo W. Barrett, Stephen F. Betz, Kevin Steffy, Kent D. Stewart, Jeffrey R. Huth, Paul L. Richardson, Jean M. Severin, Steve Muchmore, John E. Harlan, Dale J. Kempf, Kevin S. Harris, Edmund D. Matayoshi, Renaldo R. Mendoza, Vincent S. Stoll, Karl A. Walter, Kerry M. Swift, Emily E. Gramling-Evans
Publikováno v:
Journal of computer-aided molecular design. 21(1-3)
Two new proteins of approximately 70 amino acids in length, corresponding to an unnaturally-linked N- and C-helix of the ectodomain of the gp41 protein from the human immunodeficiency virus (HIV) type 1, were designed and characterized. A designed tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1d4764feb7f89ea896d6983b25aa63
https://pubmed.ncbi.nlm.nih.gov/17294246
https://pubmed.ncbi.nlm.nih.gov/17294246
Autor:
Usha Warrior, Ernst U. Frevert, William J. Chiou, David J. Burns, David A. Egan, Leo W. Barrett, Barbara L. Cool, Lemma Kifle, Paul L. Richardson, Steven N. Anderson, James L. Kofron
Publikováno v:
Journal of biomolecular screening. 9(2)
A novel and innovative high-throughput screening assay was developed to identify both activators and inhibitors of AMP-activated protein kinase (AMPK) using microarrayed compound screening (microARCS) technology. Test compounds were arrayed at a dens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba8c4e2f094ed1ec70ce017d86a0859
https://pubmed.ncbi.nlm.nih.gov/15006134
https://pubmed.ncbi.nlm.nih.gov/15006134
Autor:
Steven N. Anderson, Barbara L. Cool, Lemma Kifle, William Chiou, David A. Egan, Leo W. Barrett, Paul L. Richardson, Ernst U. Frevert, Usha Warrior, James L. Kofron, David J. Burns
Publikováno v:
Journal of Biomolecular Screening; Mar2004, Vol. 9 Issue 2, p112-121, 10p