Identification of proteome markers for drug-induced liver injury in zebrafish embryos

Autor: Marja Driessen, Suzanne van der Plas - Duivesteijn, Anne S. Kienhuis, Evert-Jan van den Brandhof, Marianne Roodbergen, Bob van de Water, Herman P. Spaink, Magnus Palmblad, Leo T.M. van der Ven, Jeroen L.A. Pennings

Publikováno v: Toxicology, 477:153262
Toxicology, 477. ELSEVIER IRELAND LTD

The zebrafish embryo (ZFE) is a promising alternative non-rodent model in toxicology, and initial studies suggested its applicability in detecting hepatic responses related to drug-induced liver injury (DILI). Here, we hypothesize that detailed analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e390d116e7267b1c543240fc51a233ff
http://hdl.handle.net/1887/3494197

Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test

Autor: Edwin P. Zwart, Ingrid Jense, Harm J. Heusinkveld, Jessica Legradi, Ellen V.S. Hessel, Alessandro Atzei, Bastiaan J. Venhuis, Leo T.M. van der Ven

Publikováno v: International Journal of Environmental Research and Public Health
Volume 18
Issue 13
International Journal of Environmental Research and Public Health, Vol 18, Iss 6717, p 6717 (2021)
Atzei, A, Jense, I, Zwart, E P, Legradi, J, Venhuis, B J, van der Ven, L T M, Heusinkveld, H J & Hessel, E V S 2021, ' Developmental neurotoxicity of environmentally relevant pharmaceuticals and mixtures thereof in a zebrafish embryo behavioural test ', International Journal of Environmental Research and Public Health, vol. 18, no. 13, 6717 . https://doi.org/10.3390/ijerph18136717
International Journal of Environmental Research and Public Health, 18(13):6717. Multidisciplinary Digital Publishing Institute (MDPI)

Humans are exposed daily to complex mixtures of chemical substances via food intake, inhalation, and dermal contact. Developmental neurotoxicity is an understudied area and entails one of the most complex areas in toxicology. Animal studies for devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fe1c045c17ab6a0ea90c7046286d3b

An adverse outcome pathway on the disruption of retinoic acid metabolism leading to developmental craniofacial defects

Autor: Anna Beronius, Francesca Metruccio, Anastasia Spyropoulou, Maria Battistoni, Johanna Zilliacus, Angelo Moretto, Kyriaki Machera, Christina H.J. Veltman, Katerina Kyriakopoulou, Francesca Di Renzo, Elena Menegola, Leo T.M. van der Ven, Mirjam Luijten

Adverse outcome pathway (AOP) is a conceptual framework that links a molecular initiating event (MIE) via intermediate key events (KEs) with adverse effects (adverse outcomes, AO) relevant for risk assessment, through defined KE relationships (KERs).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0322018121b0608f40205a9d87eb87
http://hdl.handle.net/11577/3394858

A Case Study with Triazole Fungicides to Explore Practical Application of Next-Generation Hazard Assessment Methods for Human Health

Autor: Giel Hendriks, Emiel Rorije, Mirjam Luijten, R. Corinne Sprong, Leo T.M. van der Ven, Lit-Hsin Loo, Remco Derr, Daniele Zink

Publikováno v: Chemical research in toxicology. 33(3)

The ongoing developments in chemical risk assessment have led to new concepts building on integration of sophisticated nonanimal models for hazard characterization. Here we explore a pragmatic approach for implementing such concepts, using a case stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e129659fd236e2ecd886a77d4bf69458
https://pubmed.ncbi.nlm.nih.gov/32041405

Fish embryo toxicity test, threshold approach, and moribund as approaches to implement 3R principles to the acute fish toxicity test

Autor: ZhiChao Dang, Anne S. Kienhuis, Leo T.M. van der Ven

Publikováno v: Chemosphere. 186:677-685

The acute fish toxicity test (AFT) is requested by EU legal frameworks for hazard classification and risk assessment. AFT is one of the few regulatory required tests using death as an endpoint. This paper reviews efforts made to reduce, refine and re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211a2dc9931526e1da0bfcd112b0c5ca
https://doi.org/10.1016/j.chemosphere.2017.08.047