Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Leo Sachs"'
Publikováno v:
European Journal of Haematology. 38:3-11
15 patients with acute myeloid leukaemia (AML) were treated with low-dose cytosine arabinoside (LD ARA-C). 2 patients had complete remissions, which lasted for 8 and 3 months, and 5 patients had a partial remission. 46% of the patients thus responded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae86515e852ed278a40f05ccf6ca431
https://doi.org/10.1111/j.1600-0609.1987.tb01416.x
https://doi.org/10.1111/j.1600-0609.1987.tb01416.x
Publikováno v:
Annals of the New York Academy of Sciences. 557:417-437
The development of a cell culture system for the in vitro cloning and clonal differentiation of normal hematopoietic cells made it possible to identify the proteins that regulate growth and differentiation of different hematopoietic cell lineages and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52e87d57f77e3a711f50f28ee9e503e
https://doi.org/10.1111/j.1749-6632.1989.tb24035.x
https://doi.org/10.1111/j.1749-6632.1989.tb24035.x
Autor:
Leo Sachs
Publikováno v:
Annals of the New York Academy of Sciences. 567:141-153
The establishment of a cell culture system for the clonal development of hematopoietic cells has made it possible to identify the proteins that control growth and differentiation of different hematopoietic cell lineages and to discover the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da3eef4d10de80aa4f1b40a5978c18f
https://doi.org/10.1111/j.1749-6632.1989.tb16466.x
https://doi.org/10.1111/j.1749-6632.1989.tb16466.x
Publikováno v:
Proceedings of the National Academy of Sciences. 102:18556-18561
We have analyzed gene expression data from 3 different kinds of samples: normal human tissues, human cancer cell lines and leukemic cells from lymphoid and myeloid leukemia pediatric patients. We have searched for genes that are over expressed in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c22a48d9f59e47776d6bc822e40f5c3
https://doi.org/10.1073/pnas.0509360102
https://doi.org/10.1073/pnas.0509360102
Publikováno v:
Proceedings of the National Academy of Sciences. 100:15065-15070
Proteasomal degradation of p53 is mediated by two alternative pathways that are either dependent or independent of both Mdm2 and ubiquitin. The ubiquitin-independent pathway is regulated by NAD(P)H: quinone oxidoreductase 1 (NQO1) that stabilizes p53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97d0e4aea72460ddf3682dc3b1b089d
https://doi.org/10.1073/pnas.2436329100
https://doi.org/10.1073/pnas.2436329100
Publikováno v:
Proceedings of the National Academy of Sciences. 99:13125-13130
The tumor suppressor p53 is a labile protein whose level is known to be regulated by the Mdm-2–ubiquitin–proteasome degradation pathway. We have found another pathway for p53 proteasomal degradation regulated by NAD(P)H quinone oxidoreductase 1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38aeb3cb857c98605bb99cf1dd438f3
https://doi.org/10.1073/pnas.202480499
https://doi.org/10.1073/pnas.202480499
Publikováno v:
Proceedings of the National Academy of Sciences. 98:1188-1193
The tumor suppressor gene wild-type p53 encodes a labile protein that accumulates in cells after different stress signals and can cause either growth arrest or apoptosis. One of the p53 target genes, p53-inducible gene 3 ( PIG3 ), encodes a protein w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc189561b083af61da34eb91e58d3ac
https://doi.org/10.1073/pnas.98.3.1188
https://doi.org/10.1073/pnas.98.3.1188
Publikováno v:
Proceedings of the National Academy of Sciences. 96:12016-12020
Ca2+-mobilizing compounds such as the Ca2+ionophore A23187 or the endoplasmic reticulum Ca2+ATPase inhibitor thapsigargin can suppress or induce apoptosis in the same cells. The use of different calcineurin inhibitors has shown that both suppression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741a8bf28366e64d20e62e7454395f8c
https://doi.org/10.1073/pnas.96.21.12016
https://doi.org/10.1073/pnas.96.21.12016