Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Leo S. Bleicher"'
Autor:
Leo S. Bleicher, Ton van Daelen, J. Dana Honeycutt, Moises Hassan, Jayaraman Chandrasekhar, William Shirley, Vickie Tsui, Uli Schmitz
Publikováno v:
Frontiers in Drug Discovery, Vol 2 (2022)
AI/ML methods in drug discovery are maturing and their utility and impact is likely to permeate many aspects of drug discovery including lead finding and lead optimization. Typical methods utilize ML-models for structure-property prediction with simp
Externí odkaz:
https://doaj.org/article/0207367695624b63beab647c00d02e29
Autor:
Ross A Paveley, Nuha R Mansour, Irene Hallyburton, Leo S Bleicher, Alex E Benn, Ivana Mikic, Alessandra Guidi, Ian H Gilbert, Andrew L Hopkins, Quentin D Bickle
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1762 (2012)
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics. To discover new leads we designed an a
Externí odkaz:
https://doaj.org/article/4fbeffc48c96427f856dd35cf51c26b1
Autor:
Fred H. Gage, Todd A. Carter, Pamela C. Wedel, Steven D. Targum, René Hen, Andrew A. Nierenberg, Carrolee Barlow, Maurizio Fava, Leo S. Bleicher
Publikováno v:
Journal of Psychiatric Research. 46:1553-1563
We used in vitro neurogenesis-based human neural stem cell (hNSCs) assays and rodent in vivo behavioral assays to identify potential novel antidepressants. A combination of buspirone and melatonin displayed antidepressant activity in these assays whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ec5956d6d83ce2190be7907b4baf8b
https://doi.org/10.1016/j.jpsychires.2012.08.013
https://doi.org/10.1016/j.jpsychires.2012.08.013
Autor:
Andrew L. Hopkins, Nuha R. Mansour, I. Mikic, Alessandra Guidi, Ross A. Paveley, Leo S. Bleicher, Quentin D. Bickle, Alex Benn, Irene Hallyburton, Ian H. Gilbert
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1762 (2012)
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1762 (2012)
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics. To discover new leads we designed an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b94c0ef8ddfdeb9f1cce0b4ab8af1f7
https://researchonline.lshtm.ac.uk/id/eprint/126371/1/pntd.0001762.pdf
https://researchonline.lshtm.ac.uk/id/eprint/126371/1/pntd.0001762.pdf
