Výsledky vyhledávání - "Leo R. Swett"

Pharmacological studies in the rat with [2-(2,3-didecanoyloxy)-propyl]2-acetyloxybenzoate (A-45474): An aspirin pro-drug with negligible gastric irritation

Autor: Leo R. Swett, Gerald Y. Paris, George W. Carter, Patrick R. Young

Publikováno v: Agents and Actions. 10:240-245

A triglyceride of aspirin, A-45474: [2-(1,3-didecanoyloxy)-propyl]2-acetyloxybenzoate, was developed to reduce the direct gastric irritant properties of aspirin. Studies in the rat show that oral administration of A-45474 produces anti-inflammatory a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07e673635558cec82ab0e8a1d53e2d52
https://doi.org/10.1007/bf02025942

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Pyrazolo[3,4-e] [1,4] thiazepines: Synthesis and structure proof

Autor: James D. Ratajczyk, Leo R. Swett, George H. Aynilian, Carl W. Nordeen

Publikováno v: Journal of Heterocyclic Chemistry. 12:1137-1142

Pyrazolo[3,4-e][1,4]thiazepine derivatives were obtained by reacting 5-amino-1,3-dimethylpyrazole with arylaldehydes or ketones and mercaptoacetic acid. The structure proof of these derivatives was carried out by identifying the benzylpyrazole produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8d681431fc5c5d9946f1f0389d1e31b
https://doi.org/10.1002/jhet.5570120611

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The cyclocondensation of 5-amino-1,3-dimethylpyrazole with ethyl acetoacetate. Synthesis of isomeric pyrazolopyridones

Autor: Leo R. Swett, James D. Ratajczyk

Publikováno v: Journal of Heterocyclic Chemistry. 12:517-522

The reaction of 5-amino-1,3-dimethylpyrazole with ethyl acetoacetate yielded two isomeric pyrazolopyridones which were identified as their corresponding tetrahydropyrazolopyridine derivatives and by their ir, pmr and 13C-nmr spectral data. Additional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7bf9f68591a0a64415759a0c38ddb34
https://doi.org/10.1002/jhet.5570120315

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The Facile and Efficient Preparation of Phenolic and Thiol Esters

Autor: Carl W. Nordeen, Joseph F. Dellaria, Leo R. Swett

Publikováno v: Synthetic Communications. 16:1043-1048

Phenolic and thiol esters are prepared efficiently in a facile process which involves heating the desired acyl halide and thiol or phenol as a neat mixture. Distillation after HX (X = Cl or Br) gas evolution ceases provides the title compounds in 75�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c2e8e8751927f9beacdd2cb7a62228a
https://doi.org/10.1080/00397918608056346

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Glycerides as prodrugs. 1. Synthesis and antiinflammatory activity of 1,3-bis(alkanoyl)-2-(O-acetylsalicyloyl)glycerides (aspirin triglycerides)

Autor: George W. Carter, Denis Gaston Cimon, Gerard Yvon Paris, Leo R. Swett, Patrick R. Young, David L Garmaise

Publikováno v: Journal of Medicinal Chemistry. 22:683-687

A series of 1,3-bis(alkanoyl)-2-(O-acetylsalicyloyl)glycerides (aspirin triglycerides) having aspirin at the 2 position of glycerol and fatty acids at the 1 and 3 positions was prepared. The compounds were administered orally and tested for efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5b5cb8fdf010b9d7caf273881cdd3c
https://doi.org/10.1021/jm00192a014

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