Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Leo Phillips"'
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
There are no widely-accepted prognostic markers currently available to predict outcomes in patients with triple-negative breast cancer (TNBC), and no targeted therapies with confirmed benefit. We have used MALDI mass spectrometry imaging (MSI) of try
Externí odkaz:
https://doaj.org/article/994b51c4610140f3b079fe030227be8e
Autor:
Sohel M. Julovi, Nicholas Proschogo, Leo Phillips, Aiqun Xue, Sarah F. Smith, Anthony J. Gill, Jerikho C. Bulanadi, Ross C. Smith, Thomas J. Hugh, Minoo J. Moghaddam, Kerry-Anne Rye, Xiaojuan Gong
Publikováno v:
Cancer Letters. 495:112-122
We hypothesised that synthetic HDL nanoparticles carrying a gemcitabine prodrug and apolipoprotein A-II (sHDLGemA2) would target scavenger receptor-B1 (SR-B1) to preferentially and safely deliver gemcitabine into pancreatic ductal adenocarcinoma (PDA
Publikováno v:
Cellular and Molecular Life Sciences. 76:2015-2030
Women with triple-negative breast cancer (TNBC) are generally treated by chemotherapy but their responsiveness may be blunted by DNA double-strand break (DSB) repair. We previously reported that IGFBP-3 forms nuclear complexes with EGFR and DNA-depen
Publikováno v:
Journal of Proteomics. 138:48-60
Matrix assisted laser desorption/ionisation imaging mass spectrometry (MALDI-IMS) has not previously been utilised to examine sudden infant death syndrome (SIDS). This study aimed to optimise MALDI IMS for use on archived formalin-fixed-paraffin-embe
Autor:
Christoph Naumann, John Chapman, Leo Phillips, Cristobal G. dos Remedios, Henri Wong, Daoud Hammoudeh, Robert Chisari, Garry S.H. Lee, Amy L. Foreman, Moreno Julli, Ronald W. Patra, A. Roger Cooke, Vangelis George Kanellis, D. Brynn Hibbert
Publikováno v:
Environmental Toxicology and Chemistry. 30:1810-1818
Chemical toxicants, particularly metal ions, are a major contaminant in global waterways. Live-organism bioassays used to monitor chemical toxicants commonly involve measurements of activity or survival of a freshwater cladoceran (Ceriodaphnia dubia)
Autor:
Nancy B. Amaro-Mugridge, Leo Phillips, Jennifer A. MacDiarmid, Jocelyn Madrid-Weiss, Himanshu Brahmbhatt
Publikováno v:
Cell Cycle. 6:2099-2105
Chemotherapeutic drug therapy in cancer is seriously hampered by severe toxicity primarily due to indiscriminate drug distribution and consequent collateral damage to normal cells. Molecularly targeted drugs such as cell cycle inhibitors are being de
Autor:
John Mach, David G. Le Couteur, Sarah J. Mitchell, Alice E. Kane, Rafael de Cabo, Leo Phillips, Sarah N. Hilmer, Catriona McKenzie, Brett Jones, Victoria C. Cogger, Aniko Huizer – Pajkos
Publikováno v:
Fundamentalclinical pharmacology. 30(1)
Isoniazid is the first-line treatment for tuberculosis; however, its use is limited by hepatotoxicity. Age-related differences in isoniazid pharmacokinetics and hepatotoxicity are uncertain. We aimed to investigate these in young (3 ± 0 months, n =
Autor:
Frances M. Boyle, Leo Phillips, Robert C. Baxter, Mike Z. Lin, Katrina Moore, Liping Chung, Deborah J. Marsh
Publikováno v:
Cancer letters. 368(1)
The calcium-binding protein S100P is overexpressed in various cancers and may contribute to the oncogenic phenotype. This study used mass spectrometry to characterize a novel 9.2-kDa C-terminally truncated form of S100P (t-S100P), and to investigate
Autor:
John Mach, Sarah J. Mitchell, Sarah N. Hilmer, Alice E. Kane, Aniko Huizer-Pajkos, de Cabo R, Leo Phillips, Le Couteur D
Publikováno v:
Innovation in Aging. 1:362-362
Elders are thought to be at increased risk of drug induced liver injury (DILI), however there is little empirical evidence to prove it. We aimed to determine the effect of ageing on DILI in male Fischer 344 rats. Young and old rats were treated via i
Autor:
Frances M. Boyle, Katrina Moore, Leo Phillips, Deborah J. Marsh, Liping Chung, Robert C. Baxter
Publikováno v:
Breast Cancer Research : BCR
Introduction: Serum profiling using proteomic techniques has great potential to detect biomarkers that might improve diagnosis and predict outcome for breast cancer patients (BC). This study used surface-enhanced laser desorption/ionization time-of-f