Výsledky vyhledávání - "Leo P. A. De Jong"

Immunochemical Detection of Sulfur Mustard Adducts with Keratins in the Stratum Corneum of Human Skin

Autor: Daan Noort, Roos H. Mars-Groenendijk, Hendrik P. Benschop, Lai F. Chau, Leo P. A. De Jong, A. Fidder, Govert P. van der Schans

Publikováno v: Chemical Research in Toxicology. 15:21-25

As part of a program to develop methods for diagnosis of exposure to chemical warfare agents, we developed immunochemical methods for detection of adducts of sulfur mustard to keratin in human skin. Three partial sequences of keratins containing glut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92dbd2a16c87738795bc91906932286d
https://doi.org/10.1021/tx0100136

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Diagnosis and dosimetry of exposure to sulfur mustard: development of a standard operating procedure for mass spectrometric analysis of haemoglobin adducts: exploratory research on albumin and keratin adducts

Autor: Albert G. Hulst, Daan Noort, Hendrik P. Benschop, Leo P. A. De Jong, A. Fidder

Publikováno v: Journal of Applied Toxicology. 20:S187-S192

Experiments were carried out to develop a standard operating procedure for analysis of sulfur mustard adducts to the N-terminal valine in haemoglobin and to explore adduct formation with albumin and keratin. In the first approach, gas chromatography-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ba98cd9d6a622574fa5634e2652ba18
https://doi.org/10.1002/1099-1263(200012)20:1+<::aid-jat676>3.0.co

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Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry

Autor: Yoffi Segall, Hendrik P. Benschop, Avigdor Shafferman, Arie Ordentlich, Leo P. A. De Jong, Baruch Velan, Meir Fischer, Ruth Barak, Dov Barak

Publikováno v: FEBS Letters, 3, 407, 347-352

While non-reactivability of cholinesterases from their phosphyl conjugates (aging) is attributed to an unimolecular process involving loss of alkyl group from the phosphyl moiety, no conclusive evidence is available that this is the only reaction pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12017c87bc4704cead0f7ad16a87715b
https://doi.org/10.1016/s0014-5793(97)00375-x

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Protection of Guinea Pigs against Soman Poisoning by Pretreatment withp-Nitrophenyl Phosphoramidates

Autor: Hendrik P. Benschop, Jan P. Langenberg, Leo P. A. De Jong

Publikováno v: Toxicology and Applied Pharmacology. 140:444-450

Several p-nitrophenyl phosphoramidates with the general formula RO(NH2)P(O)OC6H4-p-NO2, in which R = CH2CH3, CH2CH2F, CH2CHF2, CH2CF3, CH2CH2CH2CH3, and CH2CH2Cl, as well as (NH2)2P(O)OC6H4-p-NO2 were administered intravenously to guinea pigs as pret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8a3643dbef72d9364a45aa2968f0c4
https://doi.org/10.1006/taap.1996.0241

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Monitoring of in Vitro and in Vivo Exposure to Sulfur Mustard by GC/MS Determination of the N-Terminal Valine Adduct in Hemoglobin after a Modified Edman Degradation

Autor: Daan Noort, Ad L. de Jong, A. Fidder, Hendrik P. Benschop, and Leo P. A. de Jong, Hendrik C. Trap

Publikováno v: Chemical Research in Toxicology. 9:788-792

We report that exposure to the chemical warfare agent sulfur mustard can be monitored by means of a modified Edman degradation involving selective release of the N-terminal valine adduct of hemoglobin with the agent. The degree of alkylation of the N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4fcf33467c2b06dbb26fe6ea94ec08
https://doi.org/10.1021/tx9502150

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Retrospective Detection of Exposure to Organophosphates: Analyses in Blood of Human Beings and Rhesus Monkeys

Autor: Albert G. Hulst, H. P. Benschop, Leo P. A. De Jong, Martine Polhuijs, Jan P. Langenberg, Daan Noort

Publikováno v: NBC Risks Current Capabilities and Future Perspectives for Protection ISBN: 9780792358039

The terrorist attacks with nerve agents in Japan as well as the ongoing debate on a possible relationship between the so-called Gulf War Syndrome and accidental exposure to traces of nerve agents have made clear that improved methods for detection of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ef8296cb45a72cf01bc81726be9d59d
https://doi.org/10.1007/978-94-011-4641-8_40

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The Aromatic Moiety at Position-86 of HuAChE Accelerate the Aging of Phosphonyl-AChE Conjugates through Cation-π Interactions

Autor: Baruch Velan, Dana Stein, Yoffi Segall, H. P. Benschop, Arie Ordentlich, Leo P. A. De Jong, Dov Barak, Avigdor Shafferman

Publikováno v: Structure and Function of Cholinesterases and Related Proteins ISBN: 9781489915429

The possible involvement of cation-π interactions in stabilization of partially charged transition states has been investigated through examination of the kinetics of deal-kylation (‘aging’) for twelve alkyl methylphosphonyl conjugates of human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20e16cdef2b78e760ba7e77e7d5d0680
https://doi.org/10.1007/978-1-4899-1540-5_72

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ESMS as a Unique Tool for the Molecular Monitoring of Reactions between HuAChE and Various OP-Agents

Autor: Baruch Velan, Arie Ordentlich, Avigdor Shafferman, Meir Fischer, H. P. Benschop, Dov Barak, Ruth Barak, Leo P. A. De Jong, Yoffi Segall

Publikováno v: Structure and Function of Cholinesterases and Related Proteins ISBN: 9781489915429

The molecular masses of the bacterially expressed recombinant HuAChE and its conjugates with series of alkyl methylphosphonofluoridates and with diisopropyl fluorophosphate (DFP), were measured by electrospray - ionization mass spectrometry (ESMS). T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c37154f0691e2a6636a4c13ba7754b9
https://doi.org/10.1007/978-1-4899-1540-5_74

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Toxicokinetics of soman: species variation and stereospecificity in elimination pathways

Autor: Leo P. A. De Jong, Hendrik P. Benschop

Publikováno v: Neuroscience and biobehavioral reviews. 15(1)

Blood levels of the four stereoisomers of the nerve agent C(+/-)P(+/-)-soman were analyzed gas chromatographically in anaesthetized, artificially respirated and atropinized rats, guinea pigs and marmosets at intravenous doses of C(+/-)P(+/-)-soman co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07322af334f06f5926c4b3e422d9a8a5
https://pubmed.ncbi.nlm.nih.gov/2052202

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