Physician agreement on the diagnosis of sepsis in the intensive care unit: estimation of concordance and analysis of underlying factors in a multicenter cohort

Autor: Bert K. Lopansri, Russell R. Miller III, John P. Burke, Mitchell Levy, Steven Opal, Richard E. Rothman, Franco R. D’Alessio, Venkataramana K. Sidhaye, Robert Balk, Jared A. Greenberg, Mark Yoder, Gourang P. Patel, Emily Gilbert, Majid Afshar, Jorge P. Parada, Greg S. Martin, Annette M. Esper, Jordan A. Kempker, Mangala Narasimhan, Adey Tsegaye, Stella Hahn, Paul Mayo, Leo McHugh, Antony Rapisarda, Dayle Sampson, Roslyn A. Brandon, Therese A. Seldon, Thomas D. Yager, Richard B. Brandon

Publikováno v: Journal of Intensive Care, Vol 7, Iss 1, Pp 1-17 (2019)

Abstract Background Differentiating sepsis from the systemic inflammatory response syndrome (SIRS) in critical care patients is challenging, especially before serious organ damage is evident, and with variable clinical presentations of patients and v

Externí odkaz: https://doaj.org/article/58b777a2daf346e396ec3874647a0467

A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts.

Autor: Leo McHugh, Therese A Seldon, Roslyn A Brandon, James T Kirk, Antony Rapisarda, Allison J Sutherland, Jeffrey J Presneill, Deon J Venter, Jeffrey Lipman, Mervyn R Thomas, Peter M C Klein Klouwenberg, Lonneke van Vught, Brendon Scicluna, Marc Bonten, Olaf L Cremer, Marcus J Schultz, Tom van der Poll, Thomas D Yager, Richard B Brandon

Publikováno v: PLoS Medicine, Vol 12, Iss 12, p e1001916 (2015)

Systemic inflammation is a whole body reaction having an infection-positive (i.e., sepsis) or infection-negative origin. It is important to distinguish between these two etiologies early and accurately because this has significant therapeutic implica

Externí odkaz: https://doaj.org/article/a07d6d6c71cc4b82a59eddb9bf7995b7

Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study

Autor: Krupa Arun Navalkar, Brian A. Fox, Leo McHugh, Cristina Venturini, Antony Rapisarda, Thomas D. Yager, Eliza Gil, Evi Tsaliki, Roslyn A. Hendriks, Sian Stafford, Benjamin M. Chain, Mahdad Noursadeghi, Dayle Sampson, Laura Shallcross, Nandi Simpson, Jennifer K. Roe, Richard Bruce Brandon, Therese Seldon

Publikováno v: BMC Medicine
BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)

Background There is an urgent need to develop biomarkers that stratify risk of bacterial infection in order to support antimicrobial stewardship in emergency hospital admissions. Methods We used computational machine learning to derive a rule-out blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d0a54ebe429c461d3f68c506cb456e
https://doi.org/10.1186/s12916-020-01653-3

The effect of uncertainty in patient classification on diagnostic performance estimations

Autor: Kevin Snyder, Leo McHugh, Thomas D. Yager

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0217146 (2019)
PLoS ONE

Background The performance of a new diagnostic test is typically evaluated against a comparator which is assumed to correspond closely to some true state of interest. Judgments about the new test's performance are based on the differences between the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347cd3a1c4e78de0a7f8f509a7d3cfec
https://doaj.org/article/0d0918fa5b5741279cacaadfb30da7f3

Validation of a host response assay, SeptiCyte LAB, for discriminating sepsis from systemic inflammatory response syndrome in the ICU

Autor: Marcus J. Schultz, Greg S. Martin, Dayle Sampson, Thomas D. Yager, Robert A. Balk, Silvia Cermelli, Tom van der Poll, Stella Hahn, Richard E. Rothman, Antony Rapisarda, Annette M. Esper, Steven M. Opal, Jordan A. Kempker, Shruti Bhide, Brian A. Fox, Mitchell M. Levy, Richard Bruce Brandon, Roslyn A. Brandon, Neil R. Aggarwal, Adey Tsegaye, Krupa Arun Navalkar, Majid Afshar, Mark Yoder, Russell R. Miller, John P. Burke, Emily R. Gilbert, Paul H. Mayo, Victoria Rothwell, Franco R. D'Alessio, Gourang P. Patel, Therese Seldon, Venkataramana K. Sidhaye, Roy F. Davis, James T. Kirk, Brendon P. Scicluna, Mangala Narasimhan, Leo McHugh, Richard Newman, Bert K. Lopansri, Peter M. C. Klein Klouwenberg, Jared A. Greenberg, Jorge P. Parada

Publikováno v: American journal of respiratory and critical care medicine, 198(7), 903-913. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine

A molecular test to distinguish between sepsis and systemic inflammation of noninfectious etiology could potentially have clinical utility.This study evaluated the diagnostic performance of a molecular host response assay (SeptiCyte LAB) designed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe86da10b4868ef23566cd09454be03
https://pure.amc.nl/en/publications/validation-of-a-host-response-assay-septicyte-lab-for-discriminating-sepsis-from-systemic-inflammatory-response-syndrome-in-the-icu(9afff7c3-7587-40bd-9dd1-e75e460d9c47).html