Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Leo McCluskey"'
Autor:
Katerina Placek, Michael Benatar, Joanne Wuu, Evadnie Rampersaud, Laura Hennessy, Vivianna M Van Deerlin, Murray Grossman, David J Irwin, Lauren Elman, Leo McCluskey, Colin Quinn, Volkan Granit, Jeffrey M Statland, Ted M Burns, John Ravits, Andrea Swenson, Jon Katz, Erik P Pioro, Carlayne Jackson, James Caress, Yuen So, Samuel Maiser, David Walk, Edward B Lee, John Q Trojanowski, Philip Cook, James Gee, Jin Sha, Adam C Naj, Rosa Rademakers, The CReATe Consortium, Wenan Chen, Gang Wu, J Paul Taylor, Corey T McMillan
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Amyotrophic lateral sclerosis (ALS) is a multi‐system disease characterized primarily by progressive muscle weakness. Cognitive dysfunction is commonly observed in patients; however, factors influencing risk for cognitive dysfunction remai
Externí odkaz:
https://doaj.org/article/c97ccf4df05c438e987a0ef12c4302e4
Autor:
Marijan Posavi, Maria Diaz-Ortiz, Benjamine Liu, Christine R Swanson, R Tyler Skrinak, Pilar Hernandez-Con, Defne A Amado, Michelle Fullard, Jacqueline Rick, Andrew Siderowf, Daniel Weintraub, Leo McCluskey, John Q Trojanowski, Richard B Dewey, Xuemei Huang, Alice S Chen-Plotkin
Publikováno v:
PLoS Medicine, Vol 16, Iss 10, p e1002931 (2019)
BackgroundParkinson's disease (PD) is a progressive neurodegenerative disease affecting about 5 million people worldwide with no disease-modifying therapies. We sought blood-based biomarkers in order to provide molecular characterization of individua
Externí odkaz:
https://doaj.org/article/3caac71e01d044348e561772c1e33946
Autor:
John H Woo, Sumei Wang, Elias R Melhem, James C Gee, Andrew Cucchiara, Leo McCluskey, Lauren Elman
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105753 (2014)
To assess the relationship between clinically assessed Upper Motor Neuron (UMN) disease in Amyotrophic Lateral Sclerosis (ALS) and local diffusion alterations measured in the brain corticospinal tract (CST) by a tractography-driven template-space reg
Externí odkaz:
https://doaj.org/article/66c4e46a55e24c1e96f72d9308cb9090
Autor:
Johannes Brettschneider, Jon B Toledo, Vivianna M Van Deerlin, Lauren Elman, Leo McCluskey, Virginia M-Y Lee, John Q Trojanowski
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39216 (2012)
We evaluated clinicopathological correlates of upper motor neuron (UMN) damage in amyotrophic lateral sclerosis (ALS), and analyzed if the presence of the C9ORF72 repeat expansion was associated with alterations in microglial inflammatory activity.Mi
Externí odkaz:
https://doaj.org/article/d486916b7f83428a8465f32cb4a2239e
Autor:
Zhenming Yu, Yongqing Zhu, Alice S Chen-Plotkin, Dana Clay-Falcone, Leo McCluskey, Lauren Elman, Robert G Kalb, John Q Trojanowski, Virginia M-Y Lee, Vivianna M Van Deerlin, Aaron D Gitler, Nancy M Bonini
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17951 (2011)
Amyotrophic lateral sclerosis (ALS) is a devastating, rapidly progressive disease leading to paralysis and death. Recently, intermediate length polyglutamine (polyQ) repeats of 27-33 in ATAXIN-2 (ATXN2), encoding the ATXN2 protein, were found to incr
Externí odkaz:
https://doaj.org/article/d6438de681e04488a97fa77e38ad708b
Publikováno v:
Applied Sciences, Vol 14, Iss 3, p 1220 (2024)
The railway industry forecasts growth in passenger and freight traffic over the next 30 years. This places additional demands on rolling stock depot facilities, many of which were designed and built before the modern age of information technology. Th
Externí odkaz:
https://doaj.org/article/9d16aa7a2aa44c1090213390e141af70
Autor:
Michael Pulley, Mikko Kuoppamäki, Carolyn A Young, Jesus S. Mora Pardina, Kumaraswamy Sivakumar, Toni Sarapohja, Michael A. Elliott, Chafic Karam, Sandeep Rana, Orla Hardiman, Nathan P. Staff, Letizia Mazzini, Gabriele Mora, Thomas F. Meyer, Colleen O'Connell, Stéphanie Delstanche, Elham Bayat, Michael D. Weiss, Waqar Waheed, Nenad Mitrovic, Philippe Corcia, Marie-Hélène Soriani, Edward J. Kasarskis, Claudia Caponnetto, Dale J. Lange, Tuan Vu, Leo McCluskey, Berthold Schrank, Angela Genge, Matthew C. Kiernan, Valtteri V Aho, Manu Jokela, Philip Van Damme, Juan F. Vázquez Costa, Maurizio Inghilleri, Wolfgang Löscher, David Schultz, Tero Tapiola, Susanne Petri, Adriano Chiò, Gary L. Pattee, Julian Großkreutz, Ammar Al-Chalabi, Aziz Shaibani, Susan Mathers, Kevin J. Felice, Kimberly Goslin, James Caress, Matthias Boentert, Albert C. Ludolph, Aleksandar Radunovic, Robert D. Henderson, James Wymer, Todd Levine, Jakob Rath, Merrilee Needham, William Camu, Gaurav Guliani, Rune Johansson, Leonard H. van den Berg, Namita Goyal, Mark B. Bromberg, Bjorn Oskarsson, Annie Dionne, Eduardo Locatelli, Brent T. Harris, Suma Babu, Richard Bedlack, John Ravits, Jinsy A. Andrews, Philippe Couratier, Gabriele Siciliano, Hannu Laaksovirta, Kourosh Rezania, Lawrence Korngut, Eduardo Aguera Morales, Peter M Andersen, Eva Farrero Munoz, David Lacomis, Stephen N. Scelsa, Chris Garratt, Matthew Burford, Merit Cudkowicz, Nicholas J. Maragakis, Wendy Johnston, Martin M. Brown, Johannes Prudlo, Justin Y. Kwan, Dominic B. Fee, Senda Ajroud-Driss, Stephen A. Goutman, John Turnbull, Michael H. Rivner, Timothy M. Miller, Jan De Bleecker, Caroline Ingre, Luis Varona, Genevieve Matte, Daragh Heitzman, Robert Untucht, Lorne Zinman, Adam Quick, Jonathan S. Katz
Publikováno v:
The Lancet Neurology. 20:821-831
Summary Background There is an urgent unmet need for new therapies in amyotrophic lateral sclerosis. In a clinical study with healthy volunteers, levosimendan, a calcium sensitiser, was shown to improve neuromechanical efficiency and contractile func
Publikováno v:
Journal of Automated Reasoning. 65:727-773
The development of domain-independent planners within the AI planning community is leading to “off-the-shelf” technology that can be used in a wide range of applications. Moreover, it allows a modular approach—in which planners and domain knowl
Autor:
Sabrina, Paganoni, Fabiola, De Marchi, James, Chan, Sara K, Thrower, Nathan P, Staff, Neil, Datta, Yaz Y, Kisanuki, Vivian, Drory, Christina, Fournier, Erik P, Pioro, Stephen A, Goutman, Nazem, Atassi, Maryangel, Jeon, Sarah, Caldwell, Timothy, Mcdonough, Caroline, Gentile, Jianing, Liu, Michelle, Turner, Carol, Denny, Kevin, Felice, Misty, Green, Stephanie, Scarberry, Saad, Abu-Saleh, Beatrice, Nefussy, Debbie, Hastings, Sangri, Kim, Blake, Swihart, Ximena, Arcila-Londono, Daniel S, Newman, Michael, Silverman, Angela, Genge, Kristiana, Salmon, Lauren, Elman, Leo, Mccluskey, Kelly, Almasy, Marc, Gotkine, Kimberly, Goslin, Arlena, Cummings, Eli K, Edwards, Michael, Rivner, Kristy, Bouchard, Brandy, Quarles, Justin, Kwan, Matthew, Jaffa, Robert, Baloh, Peggy, Allred, David, Walk, Samuel, Maiser, Georgios, Manousakis, Valerie, Ferment, J Americo M, Fernandes, Pariwat, Thaisetthawatkul, Deborah, Heimes, Melissa, Phillips, Laura, Sams, Melissa, Kahler, Alecia, Corcoran, Daniel G, Larriviere, Sadie, Chotto, Gracy, Juba
Publikováno v:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 21:74-81
Primary lateral sclerosis (PLS) is a neurodegenerative disease characterized by progressive upper motor neuron dysfunction. Because PLS patients represent only 1 to 4% of patients with adult motor neuron diseases, there is limited information about t
Publikováno v:
Journal of the European Optical Society-Rapid Publications, Vol 15, Iss 1, Pp 1-10 (2019)
Precision and ultra-precision surfaces are crucial for many products – quality optics, joint & cranial implants, turbine blades, and industrial moulds & dies, to name a few. Automation in this context is distinct from standard procedures in industr