Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Leo Li-Ying Chan"'
Autor:
David Zurowski, Samir Patel, Daniel Hui, Mignane Ka, Charles Hernandez, Andrea C. Love, Bo Lin, Andrea Moore, Leo Li-Ying Chan
Publikováno v:
SLAS Discovery, Vol 28, Iss 3, Pp 65-72 (2023)
Solid tumors account for approximately 90% of all adult human cancers. As such, the development of novel cellular therapies has become of increasing importance to target solid tumor malignancies, such as prostate, lung, breast, bladder, colon, and li
Externí odkaz:
https://doaj.org/article/ef887480d688432bbe77fa082a448b37
Autor:
Haohai Zhang, Lili Feng, Paola de Andrade Mello, Changchuin Mao, Richard Near, Eva Csizmadia, Leo Li-Ying Chan, Keiichi Enjyoji, Wenda Gao, Haitao Zhao, Simon C. Robson
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Immunosuppressive cells accumulating in the tumor microenvironment constitute a formidable barrier that interferes with current immunotherapeutic approaches. A unifying feature of these tumor-associated immune and vascular endothelial cells appears t
Externí odkaz:
https://doaj.org/article/75dd513b812f4bd8b4022012fcf81fac
Autor:
Arthur-Quan Tran, Stephanie A. Sullivan, Leo Li-Ying Chan, Yajie Yin, Wenchuan Sun, Ziwei Fang, Sundeep Dugar, Chunxiao Zhou, Victoria Bae-Jump
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
SPR965 is an inhibitor of PI3K and mTOR C1/C2 and has demonstrated anti-tumorigenic activity in a variety of solid tumors. We sought to determine the effects of SPR965 on cell proliferation and tumor growth in human serous ovarian cancer cell lines a
Externí odkaz:
https://doaj.org/article/0d772ce05e77490f83637f75bbca54ae
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227950 (2020)
Trypan blue has long been the gold standard for staining dead cell to determine cell viability. The dye is excluded from membrane-intact live cells, but can enter and concentrate in membrane-compromised dead cells, rendering the cells dark blue. Over
Externí odkaz:
https://doaj.org/article/d9150c89a38a48d4bf94995defeee784
Autor:
Diane N. Ignacio, Kimberly D. Mason, Ezra C. Hackett-Morton, Christopher Albanese, Lymor Ringer, William D. Wagner, Paul C. Wang, Michael A. Carducci, Sushant K. Kachhap, Channing J. Paller, Janet Mendonca, Leo Li-Ying Chan, Bo Lin, Diane K. Hartle, Jeffrey E. Green, Collis A. Brown, Tamaro S. Hudson
Publikováno v:
Heliyon, Vol 5, Iss 1, Pp e01128- (2019)
Previously we demonstrated that muscadine grape skin extract (MSKE), a natural product, significantly inhibited androgen-responsive prostate cancer cell growth by inducing apoptosis through the targeting of survival pathways. However, the therapeutic
Externí odkaz:
https://doaj.org/article/0ec72566e263420685711b900634964a
The COVID-19 pandemic has created a worldwide public health crisis that has since resulted in 6.8 million reported deaths. The pandemic prompted the immediate response of researchers around the world to engage in rapid vaccine development, surveillan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37ffd57211c6c9c6040c516447505d8b
https://doi.org/10.21203/rs.3.rs-2846848/v1
https://doi.org/10.21203/rs.3.rs-2846848/v1
Autor:
Chao Zhou, Jean Qiu, Yaling Liu, Peter Li, Leo Li-Ying Chan, Ian Rubinoff, Sarah Kessel, Qiongyu Guo, Shunqiang Wang, Yongyang Huang
3D rendering of a HCT 116 tumor spheroid over 21 days.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a82dcae42933f8f6efd812a551640d3
https://doi.org/10.1158/0008-5472.22419137
https://doi.org/10.1158/0008-5472.22419137
Autor:
Chao Zhou, Jean Qiu, Yaling Liu, Peter Li, Leo Li-Ying Chan, Ian Rubinoff, Sarah Kessel, Qiongyu Guo, Shunqiang Wang, Yongyang Huang
Distribution of necrotic tissue in a HCT 116 tumor spheroid over time.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3369f56c0d3dc0eab0eb3bb7d8b35352
https://doi.org/10.1158/0008-5472.22419134.v1
https://doi.org/10.1158/0008-5472.22419134.v1
Autor:
Chao Zhou, Jean Qiu, Yaling Liu, Peter Li, Leo Li-Ying Chan, Ian Rubinoff, Sarah Kessel, Qiongyu Guo, Shunqiang Wang, Yongyang Huang
Three-dimensional (3D) tumor spheroid models have gained increased recognition as important tools in cancer research and anticancer drug development. However, currently available imaging approaches used in high-throughput screening drug discovery pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7ec63acd678c9072eb756ed6f821fd2
https://doi.org/10.1158/0008-5472.c.6510299.v1
https://doi.org/10.1158/0008-5472.c.6510299.v1
Autor:
Chao Zhou, Jean Qiu, Yaling Liu, Peter Li, Leo Li-Ying Chan, Ian Rubinoff, Sarah Kessel, Qiongyu Guo, Shunqiang Wang, Yongyang Huang
3D rendering of an U-87 MG tumor spheroid over 21 days.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1504aad4d0c59ea50e40f6e4a597a8
https://doi.org/10.1158/0008-5472.22419140.v1
https://doi.org/10.1158/0008-5472.22419140.v1