Mucosal CD8 T Cell Responses Are Shaped by Batf3-DC After Foodborne Listeria monocytogenes Infection

Autor: Zhijuan Qiu, Quynh-Mai Pham, Anna Andrusaite, Alberto Bravo-Blas, Leo Lefrançois, Camille Khairallah, Brian S. Sheridan, Jessica Nancy Imperato, Pedro Pérez, Lynn Puddington, Pablo A. Romagnoli, Simon Milling, Daqi Xu, Kamal M. Khanna

Publikováno v: Frontiers in Immunology, Vol 11 (2020)
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Frontiers in Immunology

While immune responses have been rigorously examined after intravenous Listeria monocytogenes (Lm) infection, less is understood about its dissemination from the intestines or the induction of adaptive immunity after more physiologic models of foodbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc42a3b4033d1201d407d872625b2fa6
https://www.frontiersin.org/article/10.3389/fimmu.2020.575967/full

CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues

Autor: Naveen Sharma, Leo Lefrançois, Alexandre P. Benechet, Kamal M. Khanna

Publikováno v: The Journal of Immunology. 195:5227-5236

CCR7 is an important chemokine receptor that regulates T cell trafficking and compartmentalization within secondary lymphoid organs. However, the T cell–intrinsic role of CCR7 during infection in the spleen is not well understood. This study was de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a38d60c2aaddb721a5115018c36b80f
https://doi.org/10.4049/jimmunol.1500993

Oral Infection Drives a Distinct Population of Intestinal Resident Memory CD8+ T Cells with Enhanced Protective Function

Autor: Leo Lefrançois, Linda S. Cauley, Quynh-Mai Pham, Young-Tae Lee, Lynn Puddington, Brian S. Sheridan

Publikováno v: Immunity. 40(5):747-757

SummaryThe intestinal mucosa promotes T cell responses that might be beneficial for effective mucosal vaccines. However, intestinal resident memory T (Trm) cell formation and function are poorly understood. We found that oral infection with Listeria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757551ebac614abec0e1b261b1fa77b8

γδ T Cells Exhibit Multifunctional and Protective Memory in Intestinal Tissues

Autor: Pablo A. Romagnoli, Han Hsuan Fu, Leo Lefrançois, Francis Alonzo, Wolf-Dieter Schubert, Brian S. Sheridan, Nancy E. Freitag, Quynh Mai Pham

Publikováno v: Immunity. 39:184-195

The study of T cell memory and the target of vaccine design has focused on memory subsumed by T cells bearing the αβ T cell receptor. Alternatively, γδ T cells are thought to provide rapid immunity particularly at mucosal borders. Here we have sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c858646656583ebf256bea68bef688
https://doi.org/10.1016/j.immuni.2013.06.015

Distinct mechanisms mediate naïve and memory CD8 T-cell tolerance

Autor: Evan R. Jellison, Leo Lefrançois, Lynn Puddington, David A. Blair, Elizabeth G. Lingenheld, Li Zu, Michael J. Turner

Publikováno v: Proceedings of the National Academy of Sciences. 109:21438-21443

Peripheral tolerance to developmentally regulated antigens is necessary to sustain tissue homeostasis. We have now devised an inducible and reversible system that allows interrogation of T-cell tolerance induction in endogenous naïve and memory CD8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080aced59ab3771d16d5473228f54233
https://doi.org/10.1073/pnas.1217409110