Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Leo Kirkovsky"'
Autor:
Surinder Kaur, Swati Gupta, Eric Fluhler, John Smeraglia, Annik Bergeron, Mark E. Arnold, Timothy V Olah, Steven J. Swanson, Adrien Musuku, Lauren Stevenson, Olivier Le Blaye, Boris Gorovits, Ann Levesque, Fabio Garofolo, Gary Schultz, Mark J. Rose, Eric Woolf, Chris Beaver, Anne-Françoise Aubry, Li Xue, Heather Myler, Jason Wakelin-Smith, Mark Bustard, Hendrik Neubert, Dawn Dufield, Stacy Ho, Akiko Ishii-Watabe, Tong-Yuan Yang, Stephen C. Alley, Matthew Szapacs, Laura Cojocaru, Surendra Bansal, Keyang Xu, Shefali Patel, Faye Vazvaei, Mark Ma, Benno Ingelse, Emma Whale, Amanda Wilson, Roger Hayes, Sam Haidar, Binodh DeSilva, Noriko Katori, Lakshmi Amaravadi, Lindsay King, Isabelle Dumont, Xiao-Yan Cai, Jeff Duggan, Albert Torri, Steve Lowes, Leo Kirkovsky, Jan Welink
Publikováno v:
Bioanalysis. 6:3237-3249
The 2014 8th Workshop on Recent Issues in Bioanalysis (8th WRIB), a 5-day full immersion in the evolving field of bioanalysis, took place in Universal City, California, USA. Close to 500 professionals from pharmaceutical and biopharmaceutical compani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a94ac5768371aa5f6d4c81919c4e34a
https://doi.org/10.4155/bio.14.279
https://doi.org/10.4155/bio.14.279
Autor:
Lin-Zhi Chen, Jan Welink, Ann Lévesque, Timothy V Olah, Jaap Wieling, Stephen Vinter, Natasha Savoie, Olivier Le Blaye, Susan Spitz, Jian Wang, Gustavo Mendes Lima Santos, Mark Bustard, Fabio Garofolo, Leo Kirkovsky, Stephen C. Alley, Sam Haidar, Emma Whale, Hendrik Neubert, Bärbel Witte, Omar F Laterza, Lee Abberley, Nilufer Tampal, Noriko Katori, Brad Ackermann, Julia Heinrich, Surinder Kaur, Michael Skelly, Patricia Brown-Augsburger, Nicola Hughes, Matthew Szapacs
Publikováno v:
Bioanalysis. 7(23)
The 2015 9th Workshop on Recent Issues in Bioanalysis (9th WRIB) took place in Miami, Florida with participation of over 600 professionals from pharmaceutical and biopharmaceutical companies, biotechnology companies, contract research organizations a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ec00e0749cdb20c4237c4fc7f1729b
https://pubmed.ncbi.nlm.nih.gov/26627049
https://pubmed.ncbi.nlm.nih.gov/26627049
Autor:
Laurie A. LeBrun, Mei Tsan, Yuefen Zhou, Frank Ruebsam, Darian M. Bartkowski, Alan X. Xiang, Ruhi Kamran, Lian-Sheng Li, Richard E. Showalter, Jingjing Zhao, Rupal Patel, Matthew Lardy, Maria V. Sergeeva, Stephen E. Webber, Amit M. Shah, David Archer Ellis, Zhongxiang Sun, Mcguire Helen, Julie Blazel, Leo Kirkovsky, Daniel A. Norris, Tran Chinh Viet, Charles R. Kissinger, Thomas G. Nolan, Peter S. Dragovich, Qing Han
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4628-4632
4-(1,1-Dioxo-1,4-dihydro-1lambda(6)-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-one analogs were discovered as a novel class of inhibitors of HCV NS5B polymerase. Structure-based design led to the identification of compound 3a that displayed pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11da5f58198cc1bc858c040e469b8f03
https://doi.org/10.1016/j.bmcl.2008.07.014
https://doi.org/10.1016/j.bmcl.2008.07.014
Autor:
Tran Chinh Viet, Charles R. Kissinger, Daniel A. Norris, Ruhi Kamran, Amit M. Shah, Jingjing Zhao, Yuefen Zhou, Rupal Patel, Matthew Lardy, Darian M. Bartkowski, Richard E. Showalter, Stephen E. Webber, Laurie A. LeBrun, Mei Tsan, Douglas E. Murphy, Sun Hee Kim, Maria V. Sergeeva, Leo Kirkovsky, Martin T. Tran, Thomas G. Nolan, Qing Han, Frank Ruebsam, Lian-Sheng Li, Peter S. Dragovich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3616-3621
Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3 k, which displayed potent inhibitory activities in biochemical and repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4ad75b76b7814c0968de6c9e82a0a6
https://doi.org/10.1016/j.bmcl.2008.04.066
https://doi.org/10.1016/j.bmcl.2008.04.066
Autor:
Tran Chinh Viet, Douglas E. Murphy, Stephen E. Webber, Bin Li, Thomas Hermann, Zhongxiang Sun, Charles R. Kissinger, Rupal Patel, Frank Ruebsam, Maria V. Sergeeva, Peter S. Dragovich, Lian-Sheng Li, Yuefen Zhou, Richard E. Showalter, Amit M. Shah, Laurie A. LeBrun, Qing Han, Qiang Zhao, Leo Kirkovsky, Mei Tsan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1413-1418
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The synthesis, structure–activity relationships (SAR), metabolic stability, and structure-based design approach for this new class of compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afbf74a4bd08648255e82b6074239c3
https://doi.org/10.1016/j.bmcl.2008.01.007
https://doi.org/10.1016/j.bmcl.2008.01.007
Autor:
Tran Chinh Viet, Benjamin K. Ayida, Peter S. Dragovich, Amit M. Shah, Huiying J. Hou, Peggy A. Thompson, Frank Ruebsam, Jingjing Zhao, Rupal Patel, Daniel A. Norris, Ruhi Kamran, Thomas G. Nolan, Stephen E. Webber, Qing Han, Charles R. Kissinger, Alan X. Xiang, Lian-Sheng Li, Darian M. Bartkowski, Jennifer Brooks, Julia Khandurina, Ellen Okamoto, Zhongxiang Sun, Mei Tsan, Laurie A. LeBrun, Mcguire Helen, Julie K. Blazel, Maria V. Sergeeva, Sun Hee Kim, Yuefen Zhou, Douglas E. Murphy, Richard E. Showalter, Leo Kirkovsky
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(22)
A novel series of non-nucleoside small molecules containing a tricyclic dihydropyridinone structural motif was identified as potent HCV NS5B polymerase inhibitors. Driven by structure-based design and building on our previous efforts in related serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae39bb556ac929997f0c827896ab2923
https://pubmed.ncbi.nlm.nih.gov/19818610
https://pubmed.ncbi.nlm.nih.gov/19818610
Autor:
Ruhi Kamran, Tran Chinh Viet, Laurie A. LeBrun, Alberto Gobbi, Jingjing Zhao, David Archer Ellis, Qiang Zhao, Julie Blazel, Rupal Patel, Matthew Lardy, Maria V. Sergeeva, Thomas G. Nolan, Qing Han, Stephen E. Webber, Amit M. Shah, Yuefen Zhou, Frank Ruebsam, Richard E. Showalter, Darian M. Bartkowski, Leo Kirkovsky, Alan X. Xiang, Lian-Sheng Li, Douglas E. Murphy, Mei Tsan, Mcguire Helen, Charles R. Kissinger, Daniel A. Norris
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(21)
The discovery of 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of the HCV RNA-dependent RNA polymerase (NS5B) is described. Several of these agents also display potent antiviral activity in cell culture experiments (EC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32973932e73fbb85f1976aadc3018491
https://pubmed.ncbi.nlm.nih.gov/19796938
https://pubmed.ncbi.nlm.nih.gov/19796938
Autor:
Noble Michael A, Frank Ruebsam, Lian-Sheng Li, Julie Blazel, Yuefen Zhou, Rupal Patel, Stephen E. Webber, Qing Han, Tran Chinh Viet, Peter S. Dragovich, Maria V. Sergeeva, Charles R. Kissinger, Laurie A. LeBrun, Amit M. Shah, David Archer Ellis, Ruhi Kamran, Douglas E. Murphy, Richard E. Showalter, Mei Tsan, Leo Kirkovsky
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(20)
The synthesis of 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones bearing 6-amino substituents as potent inhibitors of the HCV RNA-dependent RNA polymerase (NS5B) is described. Several of these a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c763409b689428bd7bc63ab47fb168
https://pubmed.ncbi.nlm.nih.gov/18796353
https://pubmed.ncbi.nlm.nih.gov/18796353
Autor:
Stephen E. Webber, Maria V. Sergeeva, Amit M. Shah, Rupal Patel, Frank Ruebsam, Leo Kirkovsky, Darian M. Bartkowski, Charles R. Kissinger, Benjamin K. Ayida, Thomas G. Nolan, Ruhi Kamran, Richard E. Showalter, Daniel A. Norris, Mei Tsan, Zhongxiang Sun, Laurie A. LeBrun, Qiang Zhao, Yuefen Zhou
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(18)
Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Among these, compound 4c displayed potent inhibitory activities in biochemical and replicon ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b2df2c4fe90fa8fcfab7f11ff7ddff
https://pubmed.ncbi.nlm.nih.gov/18722768
https://pubmed.ncbi.nlm.nih.gov/18722768