Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Leo J Pallanck"'
Autor:
Kondalarao Bankapalli, Ruth E. Thomas, Evelyn S. Vincow, Gillian Milstein, Laura V. Fisher, Leo J. Pallanck
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 9 (2024)
Externí odkaz:
https://doaj.org/article/ab4388bd87dd4f5a97d27097d5225dbd
Autor:
Perinthottathil Sreejith, Sara Lolo, Kristen R Patten, Maduka Gunasinghe, Neya More, Leo J Pallanck, Rajnish Bharadwaj
Publikováno v:
PLoS Genetics, Vol 20, Iss 2, p e1011137 (2024)
Lipid dyshomeostasis has been implicated in a variety of diseases ranging from obesity to neurodegenerative disorders such as Neurodegeneration with Brain Iron Accumulation (NBIA). Here, we uncover the physiological role of Nazo, the Drosophila melan
Externí odkaz:
https://doaj.org/article/2e871913c086410b8f22740d483d153f
Autor:
Simonetta Andreazza, Colby L. Samstag, Alvaro Sanchez-Martinez, Erika Fernandez-Vizarra, Aurora Gomez-Duran, Juliette J. Lee, Roberta Tufi, Michael J. Hipp, Elizabeth K. Schmidt, Thomas J. Nicholls, Payam A. Gammage, Patrick F. Chinnery, Michal Minczuk, Leo J. Pallanck, Scott R. Kennedy, Alexander J. Whitworth
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The role of mitochondrial DNA mutations in organismal fitness and lifespan have been studied in mitochondrial mutator models with varying results. Here, the authors generate a new APOBEC1 expression-based Drosophila mutator model and show that it has
Externí odkaz:
https://doaj.org/article/f090eaf1785247208a099d9f6a996bb3
Autor:
Kathryn A Jewett, Ruth E Thomas, Chi Q Phan, Bernice Lin, Gillian Milstein, Selina Yu, Lisa F Bettcher, Fausto Carnevale Neto, Danijel Djukovic, Daniel Raftery, Leo J Pallanck, Marie Y Davis
Publikováno v:
PLoS Genetics, Vol 17, Iss 2, p e1008859 (2021)
Abnormal protein aggregation within neurons is a key pathologic feature of Parkinson's disease (PD). The spread of brain protein aggregates is associated with clinical disease progression, but how this occurs remains unclear. Mutations in glucosidase
Externí odkaz:
https://doaj.org/article/92b88a37fcba4275938c5a5130aed9b8
Autor:
Gautam Pareek, Leo J Pallanck
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009118 (2020)
The m-AAA proteases play a critical role in the proteostasis of inner mitochondrial membrane proteins, and mutations in the genes encoding these proteases cause severe incurable neurological diseases. To further explore the biological role of the m-A
Externí odkaz:
https://doaj.org/article/20f9722ed02c47358b172da9db960780
Autor:
Colby L Samstag, Jake G Hoekstra, Chiu-Hui Huang, Mark J Chaisson, Richard J Youle, Scott R Kennedy, Leo J Pallanck
Publikováno v:
PLoS Genetics, Vol 14, Iss 11, p e1007805 (2018)
Mitochondrial DNA (mtDNA) mutations cause severe maternally inherited syndromes and the accumulation of somatic mtDNA mutations is implicated in aging and common diseases. However, the mechanisms that influence the frequency and pathogenicity of mtDN
Externí odkaz:
https://doaj.org/article/6cb3f3c6918441c4bd5d6df785a1fabc
Autor:
Ruth E Thomas, Evelyn S Vincow, Gennifer E Merrihew, Michael J MacCoss, Marie Y Davis, Leo J Pallanck
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007694 (2018)
Mutations in the glucosylceramidase beta (GBA) gene are strongly associated with neurodegenerative diseases marked by protein aggregation. GBA encodes the lysosomal enzyme glucocerebrosidase, which breaks down glucosylceramide. A common explanation f
Externí odkaz:
https://doaj.org/article/07ab2422ea4a4a228037288da3383612
Autor:
Perinthottathil Sreejith, Sara Lolo, Kristen R. Patten, Maduka Gunasinghe, Neya More, Leo J. Pallanck, Rajnish Bharadwaj
SUMMARYLipid dyshomeostasis has been implicated in a variety of diseases ranging from obesity to neurodegenerative disorders such as NBIA. Here, we uncover the physiological role of Nazo, the Drosophila homolog of the NBIA-mutated protein – c19orf1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66751ec6b3f7691dc7a4211583c05a26
https://doi.org/10.1101/2022.09.29.510106
https://doi.org/10.1101/2022.09.29.510106
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 38
mTOR is a highly conserved eukaryotic protein kinase that coordinates cell growth and metabolism and plays a critical role in cancer, immunity, and aging. It remains unclear how mTOR signaling in individual tissues contributes to whole-organism proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c4e4ad08ee4ca1a42ff4a71274b36f
https://doi.org/10.1073/pnas.2204083119
https://doi.org/10.1073/pnas.2204083119
Autor:
Jonathon L. Burman, Leslie S. Itsara, Ernst-Bernhard Kayser, Wichit Suthammarak, Adrienne M. Wang, Matt Kaeberlein, Margaret M. Sedensky, Philip G. Morgan, Leo J. Pallanck
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 10, Pp 1165-1174 (2014)
Mutations affecting mitochondrial complex I, a multi-subunit assembly that couples electron transfer to proton pumping, are the most frequent cause of heritable mitochondrial diseases. However, the mechanisms by which complex I dysfunction results in
Externí odkaz:
https://doaj.org/article/c740b63f6a234240b974a741f333415a