Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leo Holguin"'
Autor:
Min Guan, Laura Lim, Leo Holguin, Tianxu Han, Vibhuti Vyas, Ryan Urak, Aaron Miller, Diana L. Browning, Liliana Echavarria, Shasha Li, Shirley Li, Wen-Chung Chang, Tristan Scott, Paul Yazaki, Kevin V. Morris, Angelo A. Cardoso, M. Suzette Blanchard, Virginia Le Verche, Stephen J. Forman, John A. Zaia, John C. Burnett, Xiuli Wang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 344-359 (2022)
T cells engineered to express HIV-specific chimeric antigen receptors (CARs) represent a promising strategy to clear HIV-infected cells, but to date have not achieved clinical benefits. A likely hurdle is the limited T cell activation and persistence
Externí odkaz:
https://doaj.org/article/c35d7761f02247f9aa1379d906dc6325
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 321-331 (2022)
In this preclinical study, we evaluated the efficacy and feasibility of creating broad human immunodeficiency virus (HIV) resistance by simultaneously disrupting the human CCR5 and CXCR4 genes, which encode cellular co-receptors required for HIV-1 in
Externí odkaz:
https://doaj.org/article/ef1da8fe1d75483e8f4d6482e87db746
Autor:
Surya Shrivastava, Roslyn M. Ray, Leo Holguin, Lilliana Echavarria, Nicole Grepo, Tristan A. Scott, John Burnett, Kevin V. Morris
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
A strategy to control HIV-1 infection is to stably repress HIV-1 and induce “deep latency”. Here the authors show that a recombinant anti-HIV-1-1 protein can be packaged as mRNA into exosomes and delivered systemically to repress HIV-1-1 within t
Externí odkaz:
https://doaj.org/article/c2f5bfdbc83d4fcc98387b48cc1d19d1
Publikováno v:
Journal of virology. 96(3)
Humanized mouse models are based on the engraftment of human cells in immunodeficient mouse strains, most notably the NSG strain. Most used models have a major limitation in common, the development of graft-versus-host disease (GVHD). GVHD not only i
Autor:
Sylvia Illouz, Michael Pablo, Xinyue Chen, Thomas F. Rogers, Arjun Kumar, Leo Holguin, Robert Rodick, Davey M. Smith, Nathan Beutler, Gustavo Vasen, Donna Rahgoshay, Melanie Ott, John C. Burnett, Pei-Yi Chen, Leor S. Weinberger, Elizabeth Tanner, Blaise Ndjamen, Sonali Chaturvedi
Publikováno v:
Cell
Cell, vol 184, iss 25
Cell, vol 184, iss 25
Viral-deletion mutants that conditionally replicate and inhibit wild-type virus (i.e., Defective Interfering Particles, DIPs) have long been proposed as single-administration interventions with high genetic barriers to resistance. However, theories p
Autor:
Min Guan, Laura Lim, Leo Holguin, Tianxu Han, Vibhuti Vyas, Ryan Urak, Aaron Miller, Diana L. Browning, Liliana Echavarria, Shasha Li, Shirley Li, Wen-Chung Chang, Tristan Scott, Paul Yazaki, Kevin V. Morris, Angelo A. Cardoso, M. Suzette Blanchard, Virginia Le Verche, Stephen J. Forman, John A. Zaia, John C. Burnett, Xiuli Wang
Publikováno v:
Molecular therapy. Methodsclinical development. 25
T cells engineered to express HIV-specific chimeric antigen receptors (CARs) represent a promising strategy to clear HIV-infected cells, but to date have not achieved clinical benefits. A likely hurdle is the limited T cell activation and persistence
Autor:
Nagoor Pitchai, Fathima N., Tanner, Elizabeth J., Khetan, Neha, Vasen, Gustavo, Levrel, Clara, Kumar, Arjun J., Pandey, Shilpi, Ordonez, Tracy, Barnette, Philip, Spencer, David, Seung-Yong Jung, Glazier, Joshua, Thompson, Cassandra, Harvey-Vera, Alicia, Hye-In Son, Strathdee, Steffanie A., Leo Holguin, Urak, Ryan, Burnett, John, Burgess, William
Publikováno v:
Science; 8/9/2024, Vol. 385 Issue 6709, p622-622, 1p, 1 Color Photograph
In this project, we investigated the CRISPR/Cas9 system for creating HIV resistance by targeting the human CCR5 and CXCR4 genes, which encode cellular co-receptors required for HIV-1 infection. Using a clinically scalable system for transient ex vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c6adae9b3d3ec4d0984e4badb87d7c3
https://doi.org/10.1101/2021.06.30.450601
https://doi.org/10.1101/2021.06.30.450601
Humanized mouse models are based on the engraftment of human cells in immunodeficient mouse strains, most notably the NSG strain. Most used models have a major limitation in common, the development of graft-versus-host disease (GVHD). GVHD not only i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e8fa1a1055b4a0943f714e11442e13c
https://doi.org/10.1101/2021.06.03.446835
https://doi.org/10.1101/2021.06.03.446835
Autor:
Roslyn M. Ray, Kevin V. Morris, Nicole Grepo, Leo Holguin, Lilliana Echavarria, John C. Burnett, Surya Shrivastava, Tristan A. Scott
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Human Immunodeficiency Virus (HIV-1) produces a persistent latent infection. Control of HIV-1 using combination antiretroviral therapy (cART) comes at the cost of life-shortening side effects and development of drug-resistant HIV-1. An ideal and safe