Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Leo Einck"'
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68917 (2013)
The most evident challenge to treatment of Helicobacter pylori, a bacterium responsible for gastritis, peptic ulcers and gastric cancer, is the increasing rate of resistance to all currently used therapeutic antibiotics. Thus, the development of nove
Externí odkaz:
https://doaj.org/article/b4adfd0ae22f42f2b7e46354851542b7
Publikováno v:
mBio, Vol 3, Iss 2 (2012)
ABSTRACT We designed, constructed, and evaluated a prototype novel reporter system comprised of two functional cassettes: (i) the SP6 RNA polymerase gene under transcriptional control of a promoter active in mycobacteria and (ii) the consensus SP6 po
Externí odkaz:
https://doaj.org/article/dfb864677f93400f8522ffe52cbab75b
Autor:
Ying Liu, Leo Einck, Suzanne M. D'Addio, Patrick J. Sinko, Venkata M. Reddy, Robert K. Prud'homme
Publikováno v:
Molecular Pharmaceutics
Tuberculosis (TB) remains a major global health concern, and new therapies are needed to overcome the problems associated with dosing frequency, patient compliance, and drug resistance. To reduce side effects associated with systemic drug distributio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d41c782e47a042ae9d8ba04d1abef8f
http://europepmc.org/articles/PMC4423248
http://europepmc.org/articles/PMC4423248
Autor:
Margaret M. Lemmon, Jonathan Lees, Matthew C. Mulvey, Leo Einck, Carol A. Nacy, Stephanie Rotter
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:407-413
We previously reported the development of a prototype antibiotic sensitivity assay to detect drug-resistant Mycobacterium tuberculosis using infection by mycobacteriophage to create a novel nucleic acid transcript, a surrogate marker of mycobacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cb57717ac44d45f4681ac03967cdb4
https://doi.org/10.1128/aac.03135-14
https://doi.org/10.1128/aac.03135-14
Autor:
Leo Einck, Jack Ballantyne, William J. Martin, Anne S. De Groot, Robert W. Malone, Matthew Ardito, Michael Chambers, Leonard Moise
Publikováno v:
Human Vaccines & Immunotherapeutics
The integrated US Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) has made great strides in strategic preparedness and response capabilities. There have been numerous advances in planning, biothreat countermeasure development, lic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3209fcad80bd22bddd2a4e7f725cb0
Publikováno v:
Expert review of vaccines. 15(9)
Is the US ready for a biological attack using Ebola virus or Anthrax? Will vaccine developers be able to produce a Zika virus vaccine, before the epidemic spreads around the world? A recent report by The Blue Ribbon Study Panel on Biodefense argues t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaeb4d8ce450ed0b7bbaa79089b8790
https://pubmed.ncbi.nlm.nih.gov/27389971
https://pubmed.ncbi.nlm.nih.gov/27389971
Publikováno v:
Drug Delivery Letterse. 1:150-158
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d4dd032c53b034d357ebe3babbbf9f
https://doi.org/10.2174/2210303111101020150
https://doi.org/10.2174/2210303111101020150
Autor:
Elena Bogatcheva, Venkata M. Reddy, Boris Nikonenko, Leo Einck, Carol A. Nacy, Marina Protopopova
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:587-589
A phospholipid-based nanoemulsion formulation of SQ641 (SQ641-NE) was active against intracellular Mycobacterium tuberculosis in J774A.1 mouse macrophages, although SQ641 by itself was not. Intravenous (i.v.) SQ641-NE was cleared from circulation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03e8ce3fd992fc54fc052cac7237365
https://doi.org/10.1128/aac.01254-13
https://doi.org/10.1128/aac.01254-13
Autor:
Ping Chen, Colleen F. Hanrahan, Elena Bogatcheva, Leo Einck, Carol A. Nacy, Marina Protopopova, Katherine A. Sacksteder, Jacqueline Gearhart
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:201-205
As part of our ongoing research effort to develop new therapeutics for treatment of tuberculosis (TB), we synthesized a combinatorial library of 10,358 compounds on solid support using a pool-and-split technique and tested the resulting compounds for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19b7563755da093a0a83e8ecadaa0d3
https://doi.org/10.1016/j.bmcl.2009.10.135
https://doi.org/10.1016/j.bmcl.2009.10.135
Publikováno v:
Medicinal Chemistry. 3:301-316
The last 10 years have seen resurgent industry activity in discovery and development of new drugs for the treatment of tuberculosis (TB), a growing widespread and devastating (more than 2 million deaths annually) bacterial infection that is of increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b27b502eda4a3bce5242d3034945417
https://doi.org/10.2174/157340607780620626
https://doi.org/10.2174/157340607780620626