Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Leo E Otterbein"'
Autor:
John D Belcher, Edward Gomperts, Julia Nguyen, Chunsheng Chen, Fuad Abdulla, Zachary M Kiser, David Gallo, Howard Levy, Leo E Otterbein, Gregory M Vercellotti
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205194 (2018)
Carbon monoxide (CO) at low, non-toxic concentrations has been previously demonstrated to exert anti-inflammatory protection in murine models of sickle cell disease (SCD). However CO delivery by inhalation, CO-hemoglobin infusion or CO-releasing mole
Externí odkaz:
https://doaj.org/article/1af0ae6a320f4a209a40e827dfb618ef
Autor:
Leo E Otterbein
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
Externí odkaz:
https://doaj.org/article/84ba2b00056a455a8267b34da817e1aa
Autor:
Kiyoshi Itagaki, Elzbieta Kaczmarek, Yen Ting Lee, I Tien Tang, Burak Isal, Yashar Adibnia, Nicola Sandler, Melissa J Grimm, Brahm H Segal, Leo E Otterbein, Carl J Hauser
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120549 (2015)
Neutrophil extracellular traps (NETs) are critical for anti-bacterial activity of the innate immune system. We have previously shown that mitochondrial damage-associated molecular patterns (mtDAMPs), including mitochondrial DNA (mtDNA), are released
Externí odkaz:
https://doaj.org/article/3401ac467a084b0ea20497d412e5f42f
Autor:
Rodrigo W. Alves de Souza, Vanessa Voltarelli, David Gallo, Sidharth Shankar, Michael S. Tift, Mark Young, Edward Gomperts, Andrew Gomperts, Leo E. Otterbein
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)
Background Doxorubicin and other anthracyclines are crucial cancer treatment drugs. However, they are associated with significant cardiotoxicity, severely affecting patient care and limiting dosage and usage. Previous studies have shown that low carb
Externí odkaz:
https://doaj.org/article/c052d993bf7c44808e7eb723bc64da75
Autor:
Barbara Andria, Adele Bracco, Chiara Attanasio, Sigismondo Castaldo, Maria Grazia Cerrito, Santolo Cozzolino, Daniele Di Napoli, Roberto Giovannoni, Antonio Mancini, Antonino Musumeci, Ernesto Mezza, Mario Nasti, Vincenzo Scuderi, Stefania Staibano, Marialuisa Lavitrano, Leo E Otterbein, Fulvio Calise
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69972 (2013)
Ischemia reperfusion injury (IRI) in organ transplantation remains a serious and unsolved problem. Organs that undergo significant damage during IRI, function less well immediately after reperfusion and tend to have more problems at later times when
Externí odkaz:
https://doaj.org/article/4ea9aa62822e40e6944df0dcb4f212f5
Autor:
Nils Schallner, Carlos C Romão, Julia Biermann, Wolf A Lagrèze, Leo E Otterbein, Hartmut Buerkle, Torsten Loop, Ulrich Goebel
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60672 (2013)
Carbon monoxide (CO) is an accepted cytoprotective molecule. The extent and mechanisms of protection in neuronal systems have not been well studied. We hypothesized that delivery of CO via a novel releasing molecule (CORM) would impart neuroprotectio
Externí odkaz:
https://doaj.org/article/c4e13307991540928e3779e3a9e75f0b
Autor:
Shiqin Sun, Tolga Sursal, Yasaman Adibnia, Cong Zhao, Yi Zheng, Haipeng Li, Leo E Otterbein, Carl J Hauser, Kiyoshi Itagaki
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59989 (2013)
Trauma and sepsis can cause acute lung injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) in part by triggering neutrophil (PMN)-mediated increases in endothelial cell (EC) permeability. We had shown that mitochondrial (mt) damage-associated
Externí odkaz:
https://doaj.org/article/d552994591e44ead8636e687d3156162
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41982 (2012)
Carbon monoxide (CO) at low concentrations imparts protective effects in numerous preclinical small animal models of brain injury. Evidence of protection in large animal models of cerebral injury, however, has not been tested. Neurologic deficits fol
Externí odkaz:
https://doaj.org/article/af0f6077410f4e5e9674c28ac590228f
Autor:
Arvand Haschemi, Beek Yoke Chin, Markus Jeitler, Harald Esterbauer, Oswald Wagner, Martin Bilban, Leo E Otterbein
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26376 (2011)
Carbon monoxide (CO) dampens pro-inflammatory responses in a peroxisome proliferator-activated receptor-γ (PPARγ) and p38 mitogen-activated protein kinase (MAPK) dependent manner. Previously, we demonstrated that CO inhibits lipopolysaccharide (LPS
Externí odkaz:
https://doaj.org/article/015cc64070f34d9fa07ef347964cbbd0
Autor:
David H Vandorpe, Chang Xu, Boris E Shmukler, Leo E Otterbein, Marie Trudel, Frederick Sachs, Philip A Gottlieb, Carlo Brugnara, Seth L Alper
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8732 (2010)
Deoxygenation of sickle erythrocytes activates a cation permeability of unknown molecular identity (Psickle), leading to elevated intracellular [Ca(2+)] ([Ca(2+)](i)) and subsequent activation of K(Ca) 3.1. The resulting erythrocyte volume decrease e
Externí odkaz:
https://doaj.org/article/3c1e62e6debf40fdaaebb7f07b9af453